Key link between mitochondria, cocaine addiction discovered
Scientists block response in mitochondria to cocaine
- Date:
- December 20, 2017
- Source:
- University of Maryland School of Medicine
- Summary:
- Scientists have identified significant mitochondrial changes that take place in cocaine addiction, and they have been able to block them.
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For years, scientists have known that mitochondria in brain cells play a role in brain disorders such as depression, bipolar disorder, anxiety and stress responses. But recently, scientists at the University of Maryland School of Medicine (UMSOM) have identified significant mitochondrial changes that take place in cocaine addiction, and they have been able to block them.
Mitochondria serve as the power source of cells, and they play an important role in the way cells function in the body.
In mice exposed repeatedly to cocaine, UMSOM researchers identified an increase in a molecule that plays a role in mitochondria division (or fission) in a reward region of the brain. Researchers were able to block this change by using a special chemical, Mdivi-1. The researchers also blocked responses to cocaine by genetically manipulating the fission molecule within the mitochondria of brain cells, according to research published in Neuron.
"We are actually showing a new role for mitochondria in cocaine-induced behavior, and it's important for us to further investigate that role," said Mary Kay Lobo, PhD, Associate Professor of Anatomy and Neurobiology.
The researchers initially studied the mitochondria in cocaine-exposed mice and determined that mitochondria fission increased in the major reward region of the brain. To confirm this same change in humans, researchers were able to identify similar changes in the mitochondrial fission molecule in tissue collected from post mortem individuals who were cocaine dependents.
Dr. Lobo said that this latest research could help researchers better understand changes in brain cells and mitochondria from other addictive disorders. "We are interested to see if there are mitochondrial changes when animals are taking opiates. That is definitely a future direction for the lab," she said.
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Materials provided by University of Maryland School of Medicine. Note: Content may be edited for style and length.
Journal Reference:
- Ramesh Chandra, Michel Engeln, Christopher Schiefer, Mary H. Patton, Jennifer A. Martin, Craig T. Werner, Lace M. Riggs, T. Chase Francis, Madeleine McGlincy, Brianna Evans, Hyungwoo Nam, Shweta Das, Kasey Girven, Prasad Konkalmatt, Amy M. Gancarz, Sam A. Golden, Sergio D. Iñiguez, Scott J. Russo, Gustavo Turecki, Brian N. Mathur, Meaghan Creed, David M. Dietz, Mary Kay Lobo. Drp1 Mitochondrial Fission in D1 Neurons Mediates Behavioral and Cellular Plasticity during Early Cocaine Abstinence. Neuron, 2017; 96 (6): 1327 DOI: 10.1016/j.neuron.2017.11.037
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