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Experts from 14 nations discuss global gene drive project registry

Date:
December 15, 2022
Source:
University of California - San Diego
Summary:
UC San Diego Herbert Wertheim School of Public Health and Human Longevity Science led 70 participants from 14 nations in a discussion on the ways in which a gene drive project registry could both contribute to and detract from the fair development, testing and use of gene-drive modified organisms.
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FULL STORY

Advances in gene editing technologies are allowing for the development of potential new strategies for vector-borne disease control, pest management and conservation by genetically modifying organisms in a laboratory. These breakthroughs, including gene drives that are designed to spread specific genes, come with questions about their safety and ethical development.

"Recent calls to establish a global project registry before releasing any gene-drive modified organisms into the environment have suggested a registry could be valuable to coordinate research, collect data to monitor and evaluate potential ecological impacts, and facilitate transparent communication with community stakeholders and the public," said senior author Cinnamon Bloss, Ph.D., professor at the Herbert Wertheim School of Public Health and Human Longevity Science at University of California San Diego.

In December 2020, Bloss led a group that convened 70 participants from 14 nations who gathered for a two-day workshop to discuss the ways in which a gene drive project registry could both contribute to and detract from the fair development, testing and use of gene-drive modified organisms.

Reporting in the Dec. 15, 2022 online issue of Nature Biotechnology, 47 experts from organizations spanning national and local governmental agencies, international and nonprofit organizations, universities and local district vector control offices advanced the idea that a registry could serve a valuable coordinating function for multidisciplinary and multisector work activities in the area of gene drive. Gene drive is a complex area of science where professionals from many disciplines, sectors and world regions provide expertise that is necessary to develop products that could eventually be used in public health efforts.

"Historically, registries have been seen as improving transparency by making information about experimental biotechnologies or medical treatments publicly accessible," said Bloss. "Although a project registry could similarly facilitate transparency in gene drive research, one of our main conclusions was that such an effort would first require careful and inclusive deliberation with potential end-users, such as scientists, government stakeholders or local communities."

"We discussed communities' rights to inform decisions about whether a gene drive organism is released in their environment, and many of us advocated for a registry that includes detailed information for use by local decision-makers living in areas where a gene drive organism is being considered for release," said Riley Taitingfong, Ph.D., who was a postdoctoral fellow at the Herbert Wertheim School of Public Health at the time of the workshop.

"A registry could also help government regulators promote surveillance and monitoring of potential ecological and health risks," said Cynthia Triplett, M.P.H., Herbert Wertheim School of Public Health staff researcher. Taitingfong and Triplett were co-first authors.

A gene drive is a technique that genetically engineers organisms so that a particular set of genes is passed on to future generations. For example, researchers at the UC San Diego School of Biological Sciences, including co-author Omar Akbari, Ph.D., are engineering confineable gene drives in mosquitoes. They are also developing safer non-drive technologies, for example by applying CRISPR-based technology to sterilize Drosophila suzukii, an invasive fruit fly responsible for millions of dollars in crop damage.

Participants in the two-day workshop agreed that a registry could: improve learning and collaboration among the scientific community; help anticipate potential cross-interactions between gene-drive modified organisms released in the environment; promote surveillance and monitoring; and inform local decision-making and authorization by impacted communities.

The authors recommend that, as a next step, a formal needs assessment be conducted among a more diverse group of stakeholders to further address the value and utility of a global gene-drive project registry.

Co-authors at UC San Diego include:Ramya Rajagopalan, Robyn Raban, Cynthia Schairer, and Kanya Long. Full list of co-authors and institutions available in manuscript.

This research was funded, in part, by the Defense Advanced Research Projects Agency Biological Technologies Office Program (HR0011-17-2-0047).

Disclosures: Akbari is a founder of Agragene, Inc. and Synvect, Inc., with equity interest. The terms of this arrangement have been reviewed and approved by the University of California San Diego in accordance with its conflict of interest policies. Bloss served as co-chair of the Gene Drives in Biomedical Science working group of the Novel and Exceptional Technology and Research Advisory Committee of the NIH. Full disclosures available in manuscript.


Story Source:

Materials provided by University of California - San Diego. Original written by Yadira Galindo. Note: Content may be edited for style and length.


Journal Reference:

  1. Riley I. Taitingfong, Cynthia Triplett, Váleri N. Vásquez, Ramya M. Rajagopalan, Robyn Raban, Aaron Roberts, Gerard Terradas, Bridget Baumgartner, Claudia Emerson, Fred Gould, Fredros Okumu, Cynthia E. Schairer, Hervé C. Bossin, Leah Buchman, Karl J. Campbell, Anna Clark, Jason Delborne, Kevin Esvelt, Joshua Fisher, Robert M. Friedman, Gigi Gronvall, Nikos Gurfield, Elizabeth Heitman, Natalie Kofler, Todd Kuiken, Jennifer Kuzma, Pablo Manrique-Saide, John M. Marshall, Michael Montague, Amy C. Morrison, Chris C. Opesen, Ryan Phelan, Antoinette Piaggio, Hector Quemada, Larisa Rudenko, Natéwindé Sawadogo, Robert Smith, Holly Tuten, Anika Ullah, Adam Vorsino, Nikolai Windbichler, Omar S. Akbari, Kanya Long, James V. Lavery, Sam Weiss Evans, Karen Tountas, Cinnamon S. Bloss. Exploring the value of a global gene drive project registry. Nature Biotechnology, 2022; DOI: 10.1038/s41587-022-01591-w

Cite This Page:

University of California - San Diego. "Experts from 14 nations discuss global gene drive project registry." ScienceDaily. ScienceDaily, 15 December 2022. <www.sciencedaily.com/releases/2022/12/221215120713.htm>.
University of California - San Diego. (2022, December 15). Experts from 14 nations discuss global gene drive project registry. ScienceDaily. Retrieved June 12, 2024 from www.sciencedaily.com/releases/2022/12/221215120713.htm
University of California - San Diego. "Experts from 14 nations discuss global gene drive project registry." ScienceDaily. www.sciencedaily.com/releases/2022/12/221215120713.htm (accessed June 12, 2024).

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