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Methamphetamine

Methamphetamine (also referred to as methylamphetamine or desoxyephedrine) is a synthetic stimulant drug used for both medicinal and recreational purposes (the latter use is illegal in most countries). It is sometimes prescribed for ADHD and narcolepsy. It causes euphoria and excitement by acting directly on the brain's reward mechanisms, thus making it highly addictive. Methamphetamine rapidly enters the brain and causes a cascading release of norepinephrine and dopamine (and to a lesser extent, serotonin). Users may become obsessed or perform repetitive tasks such as cleaning, hand-washing or assembling and disassembling objects. Withdrawal is characterized by increased sleeping and eating, and depression-like symptoms, often accompanied by anxiety and drug-craving.

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Mind & Brain News

November 13, 2025

Researchers have uncovered surprising evidence that anxiety may be controlled not by neurons but by two dueling groups of immune cells inside the brain. These microglia act like biological pedals—one pushing anxiety forward and the other holding ...
Japanese researchers found that lecanemab, an amyloid-clearing drug for Alzheimer’s, does not improve the brain’s waste clearance system in the short term. This implies that nerve damage and impaired clearance occur early and are difficult to ...
Researchers identified SGK1 as a key chemical connecting childhood trauma to depression and suicidal behavior. High SGK1 levels were found in the brains of suicide victims and in people with genetic variants linked to early adversity. Drugs that ...
Millions struggle with depression and anxiety, often enduring long waits for effective treatment. Scientists in Sweden, Denmark, and Germany are developing a genetic test to predict which medications will actually work. Using polygenic risk scores, ...
Sertraline (Zoloft) may relieve emotional symptoms of depression and anxiety within two weeks, while physical side effects stabilize later. The research highlights how antidepressants can act on specific symptom networks rather than uniformly across ...
Researchers have identified special immune cells in the brain that help slow Alzheimer’s. These microglia work to reduce inflammation and block the spread of harmful proteins. They appear to protect memory and brain health, offering a promising ...
Prenatal exposure to the insecticide chlorpyrifos causes widespread brain abnormalities and poorer motor skills in children. Even after a residential ban, ongoing agricultural use continues to endanger developing ...
Miniature antibodies from camels and llamas can slip into the brain more easily than conventional drugs, offering a new way to treat disorders like Alzheimer’s and schizophrenia. Researchers say these “nanobodies” could reshape the future of ...
Scientists have discovered a surprising benefit of the acne drug doxycycline: it may lower the risk of schizophrenia. Teens prescribed the antibiotic were about one-third less likely to develop the condition as adults. The effect could stem from the ...
Weill Cornell researchers uncovered how free radicals from astrocyte mitochondria can fuel dementia. Using new compounds that target these radicals at their source, they slowed brain inflammation and neuronal damage in mice. The findings reveal a ...
Virginia Tech researchers have shown that memory loss in aging may be reversible. Using CRISPR tools, they corrected molecular disruptions in the hippocampus and amygdala, restoring memory in older rats. Another experiment revived a silenced memory ...
Meditation is widely praised for its mental health benefits, but new research shows that it can also produce unexpected side effects for some people—from anxiety and dissociation to functional impairment. Psychologist Nicholas Van Dam and his team ...

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