Pharmacology News
August 24, 2016

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August 24, 2016

Recommended Blood Pressure Targets for Diabetes Are Being Challenged

Aug. 23, 2016 — The Swedish National Board of Health and Welfare recently raised the recommended target blood pressure for patients with diabetes. This may lead to more patients suffering from stroke or heart ... read more

New Zika Clone Could Be New Model for Developing Vaccine

Aug. 23, 2016 — Stopping the explosive spread of Zika virus -- which can lead to birth defects in babies born to infected mothers -- depends on genetic insights gleaned through new tools and models. Researchers ... read more

New Drug Target Could Prevent Tolerance, Addiction to Opioids, Study Finds

Aug. 22, 2016 — Researchers have identified a brain mechanism that could be a drug target to help prevent tolerance and addiction to opioid pain medication, such as ... read more

Rx Associated With Fracture Risk Infrequently Reduced After Fracture Occurrence

Aug. 22, 2016 — Is the occurrence of a fragility fracture -- where Medicare beneficiaries broke a hip, wrist or shoulder -- a missed opportunity to reduce exposure to prescription drugs associated with fracture ... read more

Study Finds Better Definition of Homelessness May Help Minimize HIV Risk

Aug. 19, 2016 — Being homeless puts people at greater risk of HIV infection than those with stable housing, but targeting services to reduce risk behaviors is often complicated by fuzzy definitions of homelessness, ... read more

Aug. 19, 2016 — Rheumatoid arthritis patients taking medications that inhibit interleukin-1beta, a molecule that stimulates the immune system, are 300 times more likely to experience invasive Group A Streptococcal ... read more

New Oral Diabetes Drugs May Also Protect Patients' Kidney Health

Aug. 18, 2016 — In a clinical trial of patients with type 2 diabetes, canagliflozin (a sodium-glucose cotransporter 2 inhibitor) slowed kidney function decline to a greater extent than glimepiride (a sulfonylurea), ... read more

Smoking Marijuana Provides More Pain Relief for Men Than Women

Aug. 18, 2016 — Men had greater pain relief than women after smoking marijuana, a new study has found. Despite differences in pain relief, men and women did not report differences in how intoxicated they felt or how ... read more

Study Confirms Long-Term Effects of 'Chemobrain' in Mice

Aug. 18, 2016 — Women undergoing chemotherapy for breast cancer have long complained of lingering cognitive impairments after treatment. These effects are referred to as 'chemobrain,' a feeling of mental ... read more

Fruit Flies Could Be Key to Fighting Cervical Cancer Caused by Human Papillomavirus

Aug. 18, 2016 — HPV is one of the most common sexually transmitted infections in the US and has been identified as a cause of cancer in women. A team of researchers has completed studies on fruit flies with a ... read more

Study Supports New Strategy to Fight Cocaine Addiction

Aug. 18, 2016 — Strong evidence supporting a new strategy against drug addiction has been revealed by research. The researchers showed that a compound that inhibits the activity of certain brain-cell receptors can ... read more

Aug. 18, 2016 — Researchers have identified the protein that norovirus uses to invade cells. Norovirus is the most common viral cause of diarrhea worldwide, but scientists still know little about how it infects ... read more

Insecticide Treatment of Cattle to Kill Sand Flies and Combat Leishmaniasis

Aug. 18, 2016 — With an estimated 500,000 human infections and 50,000 deaths annually, visceral leishmaniasis (VL) is the second most prevalent parasitic killer, behind malaria. Leishmania parasites are transmitted ... read more

How Genomic Sequencing May Be Widening Racial Disparities in Cancer Care

Aug. 18, 2016 — As scientists learn more about which genetic mutations are driving different types of cancer, they're targeting treatments to small numbers of patients with the potential for big payoffs in ... read more

Nivolumab in Advanced Lung Cancer: Indication of Major Added Benefit

Aug. 18, 2016 — Patients with advanced nonsquamous NSCLC who have already undergone chemotherapy survive longer with the drug Nivolumab than with ... read more

Brivaracetam in Epilepsy: Added Benefit Still Not Proven

Aug. 18, 2016 — An indirect comparison between lacosamide and Brivaracetam for epilepsy treatment is methodologically better and covers more outcomes than the previous indirect comparisons. However, an added benefit ... read more

Emtricitabine/tenofovir Alafenamide in HIV Infection: Added Benefit Not Proven

Aug. 18, 2016 — When investigators reviewed Emtricitabine/tenofovir alafenamide in HIV infection, they found that partly no data were available, and partly the appropriate comparator therapy was not adhered to. The ... read more

Ramucirumab in Stomach Cancer: Added Benefit Not Proven

Aug. 18, 2016 — Two studies submitted were unsuitable for the assessment of an added benefit because they did not meet the specifications on the comparator therapy and on the target ... read more

Afatinib in Advanced Squamous Cell Carcinoma of the Lung: Added Benefit Not Proven

Aug. 18, 2016 — Considering Afatinib in advanced squamous cell carcinoma of the lung, neither the direct nor the indirect comparison conducted by the drug manufacturer allows conclusions on advantages or ... read more

Heart Muscle Made from Stem Cells Aid Precision Cardiovascular Medicine, Study Shows

Aug. 18, 2016 — Heart muscle cells made from induced pluripotent stem cells faithfully mirror the expression patterns of key genes in the donor's native heart tissue, according to researchers. As a result, the ... read more

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