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Pernicious anemia

Pernicious anemia refers to a type of autoimmune anemia.

Antibodies are directed against intrinsic factor or parietal cells which produce intrinsic factor.

Intrinsic factor is required for vitamin B12 absorption, so impaired absorption of vitamin B12 can result.

An anemia is a deficiency of the blood cells, but in addition to blood cells, many other cells in the body need vitamin B12, including nerve cells.

Note:   The above text is excerpted from the Wikipedia article "Pernicious anemia", which has been released under the GNU Free Documentation License.
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