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Drug Slows Blindness In AIDS Patients

Date:
March 13, 1997
Source:
Johns Hopkins Medical Institutions
Summary:
AIDS patients facing blindness from a virus infection may respond to the drug cidofovir, according to results of a multicenter study led by a Johns Hopkins researcher.

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March 12, 1997

DRUG SLOWS BLINDNESS IN AIDS PATIENTS

AIDS patients facing blindness from a virus infection may respond to the drug cidofovir, according to results of a multicenter study led by a Johns Hopkins researcher.

The drug stops progression of cytomegalovirus (CMV) retinitis, an infection of the light sensitive part of the eye and the major cause of vision loss and blindness in AIDS patients. Unlike traditional treatments that require drug delivery daily through a catheter placed in a central vein, cidofovir is injected into the arm. Central veins are large vessels, for example the jugular vein in the neck, that return blood to the heart. The researchers found that both a low and a high dose of the drug slowed progression of the disease.

"The biggest advantage is that patients receive it only once a week to start and then once every other week," says Douglas Jabs, M.D., professor of ophthalmology and medicine at The Johns Hopkins University School of Medicine. "Other drugs require that a catheter be placed in a vein and left for the duration of treatment."

A previous study by other Hopkins researchers has found that CMV retinitis accounts for 75 percent of AIDS-related CMV disease. The Studies of Ocular Complications of AIDS (SOCA) Research Group, which Jabs chairs, plans to begin another study to compare cidofovir with other drugs now used to treat CMV retinitis.

The study was funded by Gilead Sciences, which manufactures the drug. --JHMI--

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Story Source:

The above story is based on materials provided by Johns Hopkins Medical Institutions. Note: Materials may be edited for content and length.


Cite This Page:

Johns Hopkins Medical Institutions. "Drug Slows Blindness In AIDS Patients." ScienceDaily. ScienceDaily, 13 March 1997. <www.sciencedaily.com/releases/1997/03/970313085434.htm>.
Johns Hopkins Medical Institutions. (1997, March 13). Drug Slows Blindness In AIDS Patients. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/1997/03/970313085434.htm
Johns Hopkins Medical Institutions. "Drug Slows Blindness In AIDS Patients." ScienceDaily. www.sciencedaily.com/releases/1997/03/970313085434.htm (accessed October 23, 2014).

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