Featured Research

from universities, journals, and other organizations

Reversing Shock -- Gene Protects Against Cell Death

Date:
June 18, 1997
Source:
University of Maryland at Baltimore
Summary:
University of Maryland School of Medicine researchers have found a potentially powerful new weapon for medicine's war on shock. Ironically, it's an oncogene implicated in a kind of cancer called B-cell lymphoma.


University of Maryland School of Medicine researchers have found a
potentially powerful new weapon for medicine's war on shock.
Ironically, it's an oncogene implicated in a kind of cancer called
B-cell lymphoma, from which it gets its name - bcl-2. The products of
the bcl-2 gene help prevent cell death, which is a boon to a cancer
cell, although ultimately harmful to its human host.


Now bcl-2 may prove helpful in preventing cell death caused by shock.


Dr. Benjamin F. Trump, professor and chairman of pathology at the
medical school in Baltimore, and colleagues will present results of a
study of bcl-2's protective effects, at the 20th Annual Conference on
Shock, on June18 in Indian Wells, California.


"The precise mechanism by which bcl-2 inhibits cell death remains to
be defined," said Trump, "but we believe that its protective action
arises from its anti-oxidant properties, its interference with the
cellular signaling process, and its modification of calcium ion
transport within the cell."


Oxidants, which can damage cells, are released in enormous quantities
by infection, inflammation and ischemia - a blockage of blood flow -
making them a far greater threat than one might think, the pathologist
pointed out.


For more than a decade, Trump's research has focused on the role
played by ionized or electrically charged calcium, which can increase
rapidly within cells after they are damaged, activating biochemical
and metabolic changes that can lead to cell death.


Dr. Masato Ichimiya, a surgeon and research fellow in Trump's lab, and
Dr. Paul Amstad, associate professor of pathology at the University of
Maryland School of Medicine, engineered normal cells from rats'
kidneys to express extra bcl-2. Those cells proved more resistant
than normal controls to death from treatment with hydrogen peroxide.
The toxicity of hydrogen peroxide was further reduced by pretreating
cells with a chemical that binds calcium ions.


After treatment with another chemical that releases calcium ions, the
amount of positively charged intracellular calcium increased in both
bcl-2 cells and controls, but calcium levels in cells containing bcl-2
dropped again much more rapidly.


Trump said his lab's findings suggest that bcl-2 protects against two
kinds of cell death, apoptosis and oncosis. In apoptosis, most
frequently seen in normal or "programmed" cell death, a cell shrinks,
breaks into fragments and is absorbed by other housecleaning cells
known as phagocytes. Oncosis, in which a cell swells and bursts, is
more typical of cell death from shock following traumatic injury,
infection or ischemia.


"Cells overexpressing bcl-2 may prevent oxidant-induced cell death in
part by increasing the cells' ability to effectively buffer the
effects of increased calcium ions," Trump and Ichimiya concluded. "This could be significant in developing effective methods of
preventing and treating shock, which is a major cause of death.


Story Source:

The above story is based on materials provided by University of Maryland at Baltimore. Note: Materials may be edited for content and length.


Cite This Page:

University of Maryland at Baltimore. "Reversing Shock -- Gene Protects Against Cell Death." ScienceDaily. ScienceDaily, 18 June 1997. <www.sciencedaily.com/releases/1997/06/970618054634.htm>.
University of Maryland at Baltimore. (1997, June 18). Reversing Shock -- Gene Protects Against Cell Death. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/1997/06/970618054634.htm
University of Maryland at Baltimore. "Reversing Shock -- Gene Protects Against Cell Death." ScienceDaily. www.sciencedaily.com/releases/1997/06/970618054634.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins