Featured Research

from universities, journals, and other organizations

Reversing Shock -- Gene Protects Against Cell Death

Date:
June 18, 1997
Source:
University of Maryland at Baltimore
Summary:
University of Maryland School of Medicine researchers have found a potentially powerful new weapon for medicine's war on shock. Ironically, it's an oncogene implicated in a kind of cancer called B-cell lymphoma.


University of Maryland School of Medicine researchers have found a
potentially powerful new weapon for medicine's war on shock.
Ironically, it's an oncogene implicated in a kind of cancer called
B-cell lymphoma, from which it gets its name - bcl-2. The products of
the bcl-2 gene help prevent cell death, which is a boon to a cancer
cell, although ultimately harmful to its human host.


Now bcl-2 may prove helpful in preventing cell death caused by shock.


Dr. Benjamin F. Trump, professor and chairman of pathology at the
medical school in Baltimore, and colleagues will present results of a
study of bcl-2's protective effects, at the 20th Annual Conference on
Shock, on June18 in Indian Wells, California.


"The precise mechanism by which bcl-2 inhibits cell death remains to
be defined," said Trump, "but we believe that its protective action
arises from its anti-oxidant properties, its interference with the
cellular signaling process, and its modification of calcium ion
transport within the cell."


Oxidants, which can damage cells, are released in enormous quantities
by infection, inflammation and ischemia - a blockage of blood flow -
making them a far greater threat than one might think, the pathologist
pointed out.


For more than a decade, Trump's research has focused on the role
played by ionized or electrically charged calcium, which can increase
rapidly within cells after they are damaged, activating biochemical
and metabolic changes that can lead to cell death.


Dr. Masato Ichimiya, a surgeon and research fellow in Trump's lab, and
Dr. Paul Amstad, associate professor of pathology at the University of
Maryland School of Medicine, engineered normal cells from rats'
kidneys to express extra bcl-2. Those cells proved more resistant
than normal controls to death from treatment with hydrogen peroxide.
The toxicity of hydrogen peroxide was further reduced by pretreating
cells with a chemical that binds calcium ions.


After treatment with another chemical that releases calcium ions, the
amount of positively charged intracellular calcium increased in both
bcl-2 cells and controls, but calcium levels in cells containing bcl-2
dropped again much more rapidly.


Trump said his lab's findings suggest that bcl-2 protects against two
kinds of cell death, apoptosis and oncosis. In apoptosis, most
frequently seen in normal or "programmed" cell death, a cell shrinks,
breaks into fragments and is absorbed by other housecleaning cells
known as phagocytes. Oncosis, in which a cell swells and bursts, is
more typical of cell death from shock following traumatic injury,
infection or ischemia.


"Cells overexpressing bcl-2 may prevent oxidant-induced cell death in
part by increasing the cells' ability to effectively buffer the
effects of increased calcium ions," Trump and Ichimiya concluded. "This could be significant in developing effective methods of
preventing and treating shock, which is a major cause of death.


Story Source:

The above story is based on materials provided by University of Maryland at Baltimore. Note: Materials may be edited for content and length.


Cite This Page:

University of Maryland at Baltimore. "Reversing Shock -- Gene Protects Against Cell Death." ScienceDaily. ScienceDaily, 18 June 1997. <www.sciencedaily.com/releases/1997/06/970618054634.htm>.
University of Maryland at Baltimore. (1997, June 18). Reversing Shock -- Gene Protects Against Cell Death. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/1997/06/970618054634.htm
University of Maryland at Baltimore. "Reversing Shock -- Gene Protects Against Cell Death." ScienceDaily. www.sciencedaily.com/releases/1997/06/970618054634.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Obama Orders Military Response to Ebola

Obama Orders Military Response to Ebola

AP (Sep. 16, 2014) Calling the Ebola outbreak in West Africa a potential threat to global security, President Barack Obama is ordering 3,000 U.S. military personnel to the stricken region amid worries that the outbreak is spiraling out of control. (Sept. 16) Video provided by AP
Powered by NewsLook.com
UN: 20,000 Could Be Infected With Ebola by Year End

UN: 20,000 Could Be Infected With Ebola by Year End

AFP (Sep. 16, 2014) Nearly $1.0 billion dollars is needed to fight the Ebola outbreak raging in west Africa, the United Nations say, warning that 20,000 could be infected by year end. Duration: 00:40 Video provided by AFP
Powered by NewsLook.com
Obama: Ebola Outbreak Threat to Global Security

Obama: Ebola Outbreak Threat to Global Security

AP (Sep. 16, 2014) President Obama is ordering U.S. military personnel to West Africa to deal with the Ebola outbreak, which is he calls a potential threat to global security. (Sept. 16) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins