Featured Research

from universities, journals, and other organizations

Role Of Cytokines In Treating Heart Disease Unveiled By Penn Scientists

Date:
August 27, 1997
Source:
University Of Pennsylvania Medical Center
Summary:
Researchers from the University of Pennsylvania Medical Center and other institutions are starting to amass solid evidence to explain how a popular heart medication works on a molecular level.

Researchers from the University of Pennsylvania Medical Center and other institutions are starting to amass solid evidence to explain how a popular heart medication works on a molecular level. Specifically, the scientists investigated the role of cytokines (bodily proteins that regulate inflammation) in explaining the effectiveness of amlodipine, a widely prescribed calcium-channel blocker for patients with heart failure. "A better understanding of the relationship between cytokines and amlodipine will hopefully open the door to develop more effective therapies for congestive heart failure, a condition that affects about three million Americans," says Emile R. Mohler, III, MD, director of vascular medicine at Penn. Mohler presents his findings today at the European Congress of Cardiology in Stockholm Sweden.

Related Articles


Cytokines, an area of active research on many fronts, are proteins that regulate the intensity and duration of the inflammatory response. People suffering from heart failure, as well as many other diseases, have higher levels of two such proteins--tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6)--circulating in their blood. "Inflammation is quite prevalent in heart disease, and amlodipine somehow dampens this inflammatory process," explains Mohler.

Researchers currently believe that the release of cytokines may affect the function of heart tissue by initiating programmed cell death in the myocardium. Over the course of 26 weeks, Mohler and his team found that amlodipine given to heart patients lowered their plasma levels of IL-6.

"I think the intriguing aspect of these results is that amlodipine may have a beneficial action in heart failure patients by reducing cytokines, although this has to be explored further in follow-up studies," says Mohler.

The research team postulated that cytokine levels may also have some prognostic value for treating heart disease. Using a statistical model, Mohler and his colleagues found that congestive heart failure or death was more likely to occur in patients with higher levels of IL-6. "By measuring cytokines it may help us to identify those patients who may respond better to therapy," he says. "For example, if cytokine levels tend to be lower, your chances of living longer with heart failure may be better."

Dr. Mohler's findings appear in the July 1997 issue of the Journal of the American College of Cardiology. This work was funded by the National Institutes of Health and Pfizer Corp.

Dr. Mohler can be reached at 215-662-9016 until Aug. 22, 1997, after which time he leaves for Sweden. He returns Aug. 29.

The University of Pennsylvania Medical Center's sponsored research ranks fifth in the United States, based on grant support from the National Institutes of Health, the primary funder of biomedical research in the nation. In federal fiscal year 1996, the medical center received $149 million. In addition, for the second consecutive year, the institution posted the highest growth rate in research activity--9.1 percent--of the top-ten U.S. academic medical centers during the same period. News releases from the medical center are available to reporters by direct E-mail, fax, or U.S. mail, upon request. They are also posted to the center's home page (http://www.med.upenn.edu) and EurekAlert! (http://www.eurekalert.org), an Internet resource sponsored by the American Association for the Advancement of Science.


Story Source:

The above story is based on materials provided by University Of Pennsylvania Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University Of Pennsylvania Medical Center. "Role Of Cytokines In Treating Heart Disease Unveiled By Penn Scientists." ScienceDaily. ScienceDaily, 27 August 1997. <www.sciencedaily.com/releases/1997/08/970827054725.htm>.
University Of Pennsylvania Medical Center. (1997, August 27). Role Of Cytokines In Treating Heart Disease Unveiled By Penn Scientists. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/1997/08/970827054725.htm
University Of Pennsylvania Medical Center. "Role Of Cytokines In Treating Heart Disease Unveiled By Penn Scientists." ScienceDaily. www.sciencedaily.com/releases/1997/08/970827054725.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Reuters - Innovations Video Online (Oct. 29, 2014) A Swedish amputee who became the first person to ever receive a brain controlled prosthetic arm is able to manipulate and handle delicate objects with an unprecedented level of dexterity. The device is connected directly to his bone, nerves and muscles, giving him the ability to control it with his thoughts. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Google To Use Nanoparticles, Wearables To Detect Disease

Google To Use Nanoparticles, Wearables To Detect Disease

Newsy (Oct. 29, 2014) Google X wants to improve modern medicine with nanoparticles and a wearable device. It's all an attempt to tackle disease detection and prevention. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins