Featured Research

from universities, journals, and other organizations

University Of Cincinnati Chemists Develop High-Efficiency Method To Synthesize And Screen Potential Antibiotics

Date:
September 10, 1997
Source:
University Of Cincinnati
Summary:
University of Cincinnati researchers have developed a system for quickly synthesizing and screening potential replacements for standard antibiotics, such as penicillin and amoxicillin. All of these antibiotics fall into the category known as beta lactams.

Cincinnati -- University of Cincinnati researchers have developed a system for quickly synthesizing and screening potential replacements for standard antibiotics, such as penicillin and amoxicillin. All of these antibiotics fall into the category known as beta lactams.

Chemistry graduate student Jie Wang will explain a key part of the system Sunday, Sept. 7 during the national meeting of the American Chemical Society in Las Vegas.

The system, developed by Professor Richard Day, uses a patented intermediate compound (a Leuchs anhydride) for rapid synthesis of novel antibiotics. It is coupled with a high- throughput method for screening the compounds' activity. The complete process takes about two days.

"We have over 1,000 novel beta lactams," said Day. "Most of them test out as being very effective against a wide range of bacteria."

More importantly, several of the compounds are effective at extremely low levels. The typical minimum inhibitory concentration (or MIC) of prescription beta lactams falls between 0.1 and 1.0 microgram per milliliter. Some of the compounds developed in Day's lab were effective at the sub-nanogram level.

That might make it possible to develop antibiotic skin patches. The patches have an advantage over pills, because the patient would not have to remember when to take medicine, and doctors would not have to worry that the patient did not finish all the medication.

The most promising antibiotics have been tested in the lab against both Gram-negative and Gram-positive bacteria, against resistant and non-resistant strains of bacteria, and against a "defanged" version of the microbe that causes tuberculosis.

The results were encouraging, although Day knows these compounds have a long way to go before any of them could reach human testing. "We can make beta lactams that take out the tuberculosis bacteria without any trouble, but there's a big jump between the test tube and elsewhere," Day readily admits.

The focus of Wang's presentation will be on the analytical methods used to identify and separate the various isomers produced by Day's synthetic approach.

"The important result to having access to all these isomers is we found some are lytic and some are non-lytic to bacteria," said Day.

The lytic antibiotics actually burst open the bacterial cells. The non-lytic forms inhibit growth without destroying the bacteria. That's important, because some bacteria contain extremely dangerous toxins which can cause severe complications. For example, the plague bacteria contains a heart toxin and the bacteria which causes meningitis contains a neurotoxin. Non-lytic antibiotics may prove to be much safer than currently available drugs.


Story Source:

The above story is based on materials provided by University Of Cincinnati. Note: Materials may be edited for content and length.


Cite This Page:

University Of Cincinnati. "University Of Cincinnati Chemists Develop High-Efficiency Method To Synthesize And Screen Potential Antibiotics." ScienceDaily. ScienceDaily, 10 September 1997. <www.sciencedaily.com/releases/1997/09/970910053221.htm>.
University Of Cincinnati. (1997, September 10). University Of Cincinnati Chemists Develop High-Efficiency Method To Synthesize And Screen Potential Antibiotics. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/1997/09/970910053221.htm
University Of Cincinnati. "University Of Cincinnati Chemists Develop High-Efficiency Method To Synthesize And Screen Potential Antibiotics." ScienceDaily. www.sciencedaily.com/releases/1997/09/970910053221.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins