Featured Research

from universities, journals, and other organizations

High Blood Levels Of Insulin Possible Independent Predictor Of Heart Attack Risk

Date:
August 14, 1998
Source:
American Heart Association
Summary:
Many people with diabetes develop heart disease, but a new study says that determining who has high levels of insulin in the blood -- a condition that precedes diabetes -- may better predict who is at risk for having a heart attack.

DALLAS, Texas, Aug. 4, 1998 -- Many people with diabetes develop heart disease, but a new study says that determining who has high levels of insulin in the blood -- a condition that precedes diabetes -- may better predict who is at risk for having a heart attack.

In today's Circulation: Journal of the American Heart Association, Finnish researchers say measuring a person's extent of hyperinsulinemia -- a condition that occurs when the body's cells are unable to effectively use the hormone insulin to break down sugar in food -- was superior to measuring other risk factors in determining whether individuals would have heart attacks.

"Over 22 years of follow-up, the predictive power of insulin levels was of the same magnitude as that of cholesterol levels," says the study's senior author, Kalevi Pyorala, M.D., of the department of medicine at the University of Kuopio in Finland. "With additional adjustment for other risk factors, insulin levels remained, with the exception of the first five years, a significant independent predictor of heart attack risk."

When compared to other risk factors, insulin levels were the most statistically significant predictor of heart attack risk during the study. As participants in the study grew older, blood pressure became a significant predictor. After the first 10 years of the study, smoking predicted heart attack risk. The researchers say that body mass index, blood levels of the fat triglyceride, and physical inactivity showed no association to heart attack risk.

The study was based on a group of 970 men, 34 to 64 years of age, who were free of cardiovascular disease and diabetes. During the 22-year span of the study, 164 of them had a heart attack.

At the first five-year follow-up, the scientists found that those people with the highest levels of insulin were more than three times as likely to have a heart attack as those with the lowest levels of insulin. In a follow-up examination 10 years after the study began, those with highest insulin levels were at 2.7 times greater risk than those at the lowest levels.

Although hyperinsulinemia was shown to be a strong predictor of heart attack risk, its ability to predict future heart attacks diminished over time. The predictability of risk by use of insulin levels continued to slide during the later years of the study. Fifteen years after the study began, the risk had dropped to 2.1 times greater risk, and at 22 years, those with high insulin levels were at 1.6 times greater risk.

"A relatively strong association of hyperinsulinemia to heart attack risk during the early part of the follow-up, as was the case in our study, may lead to selective morbidity and mortality, which could weaken the predictive value of hyperinsulinemia," says Pyorala. "People with the highest insulin levels may die and become ill sooner than those with normal levels of the hormone.

"Second, the cumulative impact of other risk factors may override the impact of hyperinsulinemia or insulin resistance during long follow-up periods."

The researchers say that this study adds to the growing body of evidence showing that diabetes and insulin levels are important predictors of heart attack risk. However, they point out that the various findings of these studies raise more questions for research.

"Although the results of our study clearly demonstrated a statistically independent association of hyperinsulinemia to heart attack risk, we want to emphasize that this association may still be explained through other factors clustering with hyperinsulinemia and insulin resistance," says Pyorala. "On the basis of present evidence, doctors do not necessarily need to screen patients for hyperinsulinemia."

The American Heart Association says that people with diabetes can avoid or delay heart disease and stroke by controlling weight and blood cholesterol with a low-saturated-fat, low-cholesterol diet and regular exercise coupled with lowering blood pressure and not smoking.

Co-authors are Marja Pyorala, M.D.; Heikki Miettinen, M.D.; and Markku Laakso, M.D.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Cite This Page:

American Heart Association. "High Blood Levels Of Insulin Possible Independent Predictor Of Heart Attack Risk." ScienceDaily. ScienceDaily, 14 August 1998. <www.sciencedaily.com/releases/1998/08/980814065131.htm>.
American Heart Association. (1998, August 14). High Blood Levels Of Insulin Possible Independent Predictor Of Heart Attack Risk. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/1998/08/980814065131.htm
American Heart Association. "High Blood Levels Of Insulin Possible Independent Predictor Of Heart Attack Risk." ScienceDaily. www.sciencedaily.com/releases/1998/08/980814065131.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com
Tooth Plaque Provides Insight Into Diets Of Ancient People

Tooth Plaque Provides Insight Into Diets Of Ancient People

Newsy (July 19, 2014) Research on plaque from ancient teeth shows that our prehistoric ancestor's had a detailed understanding of plants long before developing agriculture. Video provided by Newsy
Powered by NewsLook.com
Contaminated Water Kills 3 Babies in South African Town

Contaminated Water Kills 3 Babies in South African Town

AFP (July 18, 2014) Contaminated water in South Africa's northwestern town of Bloemhof kills three babies and hospitalises over 500 people. The incident highlights growing fears over water safety in South Africa. Duration: 02:22 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins