Featured Research

from universities, journals, and other organizations

Cyclosporin Appears Effective In Treating Heart Disease, According To Study In Science

Date:
September 12, 1998
Source:
Children's Hospital Medical Center Of Cincinnati
Summary:
The drug cyclosporin may be effective in treating hypertrophic cardiomyopathy (HCM), a heart disease cited as the most frequent cause of sudden death in young adults and young athletes, according to a new study by researchers at Children's Hospital Medical Center of Cincinnati.

CINCINNATI - The drug cyclosporin may be effective in treating hypertrophic cardiomyopathy (HCM), a heart disease cited as the most frequent cause of sudden death in young adults and young athletes, according to a new study by researchers at Children's Hospital Medical Center of Cincinnati.

The study, to be published in the September 11 edition of Science, shows that cyclosporin, a drug commonly used to prevent rejection of transplanted organs, prevents HCM in rats and mice. The study was led by Jeffery D. Molkentin, Ph.D., a researcher in the division of molecular cardiovascular biology and a Pew Scholar at Cincinnati Children's.

HCM is an inherited form of heart disease that affects one in 500 individuals. The disease starts as a general enlargement of the heart's middle muscular layer and can ultimately progress to heart failure. Several forms of inherited heart disease, including HCM, are associated with genetic mutations that cause thickening of the heart muscle wall. This thickening is known as cardiac hypertrophy.

In a previous study, published in April in the journal Cell, Dr. Molkentin and his colleagues showed that the enzyme calcineurin can initiate cardiac hypertrophy in mice. In the new study, the scientists administered a calcineurin inhibitor, cyclosporin, to mice that were genetically predisposed to develop HCM and to rats in which HCM was induced. This prevented the development of HCM.

"These results suggest that calcineurin inhibitors merit further study as potential treatments for certain forms of human heart disease," says Dr. Molkentin. "Because long-term use of cyclosporin may have adverse side effects, different calcineurin inhibitors may need to be developed."


Story Source:

The above story is based on materials provided by Children's Hospital Medical Center Of Cincinnati. Note: Materials may be edited for content and length.


Cite This Page:

Children's Hospital Medical Center Of Cincinnati. "Cyclosporin Appears Effective In Treating Heart Disease, According To Study In Science." ScienceDaily. ScienceDaily, 12 September 1998. <www.sciencedaily.com/releases/1998/09/980912111552.htm>.
Children's Hospital Medical Center Of Cincinnati. (1998, September 12). Cyclosporin Appears Effective In Treating Heart Disease, According To Study In Science. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/1998/09/980912111552.htm
Children's Hospital Medical Center Of Cincinnati. "Cyclosporin Appears Effective In Treating Heart Disease, According To Study In Science." ScienceDaily. www.sciencedaily.com/releases/1998/09/980912111552.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins