Featured Research

from universities, journals, and other organizations

Additional Damage From Heart Attack Occurs Within 48 Hours of Recovery

Date:
October 22, 1998
Source:
Johns Hopkins Medical Institutions
Summary:
The tiniest blood vessels nourishing the heart are at risk of damage not only during a heart attack but also after normal blood flow returns through the region, a Johns Hopkins-led animal study has found.

The tiniest blood vessels nourishing the heart are at risk of damage not only during a heart attack but also after normal blood flow returns through the region, a Johns Hopkins-led animal study has found.

The study used magnetic resonance imaging (MRI) for the first time to measure the extent and time course of capillary blockage following simulated heart attacks in laboratory animals. Researchers found that the obstruction is uneven in these vessels and increases up to threefold during the 48 hours following return of blood flow. The consequences can affect nearly 10 percent of the left ventricle -- the heart's main pumping chamber.

Results of the study, supported by the American Heart Association and the National Heart, Lung and Blood Institute, were published in the Sept. 8 issue of Circulation: Journal of the American Heart Association.

During a heart attack, dying blood cells and debris can clog the heart's capillaries -- the body's narrowest blood vessels. If the vessels stay clogged for a long time, the capillaries remain blocked, preventing return of normal blood flow even after the body recovers from a heart attack. This can put a patient at risk for later complications, such as another heart attack, congestive heart failure or stroke.

In treating heart attack patients, physicians try to reperfuse -- or return blood flow -- to the area using drugs, angioplasty or surgery.

"But reperfusion is not uniform," says Carlos E. Rochitte, M.D., lead author of the study and a postdoctoral cardiology fellow at Hopkins. "The core area affected by the attack may be damaged so badly that the capillaries remain blocked."

Identifying the extent of obstruction early could aid in the development of new medications to open up the blocked vessels, according to Jo o A.C. Lima, M.D., and David A. Bluemke, M.D., Ph.D., senior authors of the study.

Researchers studied vascular obstruction in animal models by blocking the coronary arteries for 90 minutes to simulate a heart attack. Then they observed the region of the heart attack two hours, six hours and 48 hours following return of blood flow. At two hours, vascular obstruction affected an average of 3.2 percent of the left ventricle. At six hours, obstruction affected an average of 6.7 percent of the left ventricle; at 48 hours, the obstruction affected an average of 9.9 percent of the left ventricle.

Further study is necessary to determine why some people have more obstruction than others, Rochitte says.

The study's other authors were Scott B. Reeder, Ph.D.; Elliot R. McVeigh, Ph.D.; Toshiya Furuta, M.D.; and Lewis C. Becker, M.D., of Hopkins; and Jacques A. Melin, M.D., of the University of Louvain, Brussels, Belgium.

--JHMI--

Johns Hopkins Medical Institutions' news releases are available on a PRE-EMBARGOED basis on EurekAlert at http://www.eurekalert.org, Newswise at http://www.newswise.com and from the Office of Communications and Public Affairs' direct e-mail news release service. To enroll, call 410-955-4288 or send e-mail to bsimpkins@jhmi.edu.

On a POST-EMBARGOED basis find them at http://hopkins.med.jhu.edu, Quadnet at http://www.quad-net.com and ScienceDaily at http://www.sciencedaily.com.


Story Source:

The above story is based on materials provided by Johns Hopkins Medical Institutions. Note: Materials may be edited for content and length.


Cite This Page:

Johns Hopkins Medical Institutions. "Additional Damage From Heart Attack Occurs Within 48 Hours of Recovery." ScienceDaily. ScienceDaily, 22 October 1998. <www.sciencedaily.com/releases/1998/10/981021101511.htm>.
Johns Hopkins Medical Institutions. (1998, October 22). Additional Damage From Heart Attack Occurs Within 48 Hours of Recovery. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/1998/10/981021101511.htm
Johns Hopkins Medical Institutions. "Additional Damage From Heart Attack Occurs Within 48 Hours of Recovery." ScienceDaily. www.sciencedaily.com/releases/1998/10/981021101511.htm (accessed September 30, 2014).

Share This



More Health & Medicine News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How 'Yes Means Yes' Defines Sexual Assault

How 'Yes Means Yes' Defines Sexual Assault

Newsy (Sep. 29, 2014) Aimed at reducing sexual assaults on college campuses, California has adopted a new law changing the standard of consent for sexual activity. Video provided by Newsy
Powered by NewsLook.com
Scientists May Have Found An Early Sign Of Pancreatic Cancer

Scientists May Have Found An Early Sign Of Pancreatic Cancer

Newsy (Sep. 29, 2014) Researchers looked at 1,500 blood samples and determined people who developed pancreatic cancer had more branched chain amino acids. Video provided by Newsy
Powered by NewsLook.com
Colo. Doctors See Cluster of Enterovirus Cases

Colo. Doctors See Cluster of Enterovirus Cases

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com
Dr.'s Unsure of Cause of Fast-Spreading Virus

Dr.'s Unsure of Cause of Fast-Spreading Virus

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins