Featured Research

from universities, journals, and other organizations

Enzyme Causes Brain Blood Vessels To Enlarge During Injury, Study Shows

Date:
January 21, 1999
Source:
University Of Iowa College Of Medicine
Summary:
An enzyme notorious for making a bad situation worse when it comes to inflammation causes the brain's blood vessels to dilate when the brain becomes injured, a University of Iowa study revealed.

IOWA CITY, Iowa -- An enzyme notorious for making a bad situation worse when it comes to inflammation causes the brain's blood vessels to dilate when the brain becomes injured, a University of Iowa study revealed.

Related Articles


In the recent study, Eddie Brian, M.D., UI associate professor of anesthesia, found that when exposed to inflammatory stimuli, the brain in a rat model expressed the enzyme cyclooxygenase-2 (COX-2), which led the brain's blood vessels to dilate.

Learning about brain inflammation is important because the effects from inflammation often cause more damage than the initial injury itself, Brian said. All brain injuries -- including stroke, head injury, cerebral ischemia, infection (meningitis), HIV dementia and multiple sclerosis -- have an inflammatory component.

"Dilation of brain blood vessels during brain inflammation may have an important deleterious effect, as the brain is normally very dependent on its highly regulated blood flow," Brian said. "During inflammation, if brain blood vessels dilate, then blood flow can become maldistributed in the brain, leading to ischemia or brain damage."

COX-2, which researchers discovered only this decade, is an important inflammatory mechanism and plays a role in other conditions such as arthritis. Under normal conditions, cells do not express COX-2. However, when injury or inflammation occur, COX-2 kicks in and produces inflammatory compounds from precursors that exist in all cells. These compounds lead to increased inflammation.

Before investigators can develop therapy to combat COX-2 in the brain, they must first understand what causes the brain to express the enzyme when the brain becomes injured. Brian plans to continue his investigation in that area and hopes to probe more extensively into how COX-2 affects other aspects of the brain and injury.

"Understanding inflammation in the brain may lead to therapy to limit inflammation and limit secondary brain damage," Brian said.

The other UI investigators involved in Brian's research included Steven A. Moore, M.D., professor of pathology, and Frank M. Faraci, Ph.D., associate professor of internal medicine and pharmacology.

Brian's work appeared in the December issue of Stroke.


Story Source:

The above story is based on materials provided by University Of Iowa College Of Medicine. Note: Materials may be edited for content and length.


Cite This Page:

University Of Iowa College Of Medicine. "Enzyme Causes Brain Blood Vessels To Enlarge During Injury, Study Shows." ScienceDaily. ScienceDaily, 21 January 1999. <www.sciencedaily.com/releases/1999/01/990121073124.htm>.
University Of Iowa College Of Medicine. (1999, January 21). Enzyme Causes Brain Blood Vessels To Enlarge During Injury, Study Shows. ScienceDaily. Retrieved April 18, 2015 from www.sciencedaily.com/releases/1999/01/990121073124.htm
University Of Iowa College Of Medicine. "Enzyme Causes Brain Blood Vessels To Enlarge During Injury, Study Shows." ScienceDaily. www.sciencedaily.com/releases/1999/01/990121073124.htm (accessed April 18, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Saturday, April 18, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Scientists Find Link Between Gestational Diabetes And Autism

Scientists Find Link Between Gestational Diabetes And Autism

Newsy (Apr. 17, 2015) Researchers who analyzed data from over 300,000 kids and their mothers say they&apos;ve found a link between gestational diabetes and autism. Video provided by Newsy
Powered by NewsLook.com
Video Messages Help Reassure Dementia Patients

Video Messages Help Reassure Dementia Patients

AP (Apr. 17, 2015) Family members are prerecording messages as part of a unique pilot program at the Hebrew Home in New York. The videos are trying to help victims of Alzheimer&apos;s disease and other forms of dementia break through the morning fog of forgetfulness. (April 17) Video provided by AP
Powered by NewsLook.com
Common Pain Reliever Might Dull Your Emotions

Common Pain Reliever Might Dull Your Emotions

Newsy (Apr. 16, 2015) Each week, millions of Americans take acetaminophen to dull minor aches and pains. Now researchers say it might blunt life&apos;s highs and lows, too. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins