Featured Research

from universities, journals, and other organizations

University Of Hawaii Scientists Announce First Male Clone

Date:
June 1, 1999
Source:
University Of Hawaii
Summary:
It took Adam's rib to produce a female companion, but University of Hawaii scientists needed just the tip of a mouse tale to create the first male clone. Researchers Teruhiko Wakayama and Ryuzo Yanagimachi, who introduced the Honolulu Technique for cloning mice a year ago, have used the technique to produce the first male mice clones.

It took Adam's rib to produce a female companion, but University of Hawaii scientists needed just the tip of a mouse tale to create the first male clone.

Researchers Teruhiko Wakayama and Ryuzo Yanagimachi, who introduced the Honolulu Technique for cloning mice a year ago, have used the technique to produce the first male mice clones. Their report appears in the June issue of the journal Nature Genetics.

Like Dolly the sheep, Cumulina and the scores of subsequent mice clones produced at the University of Hawaii at Manoa are female. All were produced from cells related to the female reproductive system; a mammary gland cell was used to create Dolly and cumulus cells, which surround developing eggs within the ovaries, used to clone the mice. Even cattle cloned in Japan are reported to come from cells related to the femal reproductive system. To create male mice, UH scientists have now used cells taken from the tip of adult male tails.

In the Honolulu Technique, the nucleus extracted from a donor cell is injected into enucleated egg from a separate female (an egg cell from which all genetic information has been removed). The eggs are activated to begin dividing and the developing embryos transplanted into a foster mother.

The technique produced three live male offspring from tale-tip cells late last fall. Two died shortly after birth, but the surviving clone, dubbed Fibro because the cultured tale-tip cells resemble fibroblasts, has developed normally and mated successfully, producing two healthy litters.

"When we produced mouse clones last year, people asked if it could be done with males. We knew that females, males made no difference," said Yanagimachi, a professor of anatomy and reproductive biology in UH Manoa's John A. Burns School of Medicine. Although only three in 274 transplanted embryos reached full term, Yanagimachi called the low survival rate "a barrier that still can be overcome."

The research is important because it shows that animals of either sex can be cloned and that somatic cells (non reproductive cells) can be used. "Precious animals of either sex" for example, endangered species and transgenic animals "can be propagated by cloning, irrespective of their fertility status," the Nature Genetics article concludes.


Story Source:

The above story is based on materials provided by University Of Hawaii. Note: Materials may be edited for content and length.


Cite This Page:

University Of Hawaii. "University Of Hawaii Scientists Announce First Male Clone." ScienceDaily. ScienceDaily, 1 June 1999. <www.sciencedaily.com/releases/1999/06/990601081911.htm>.
University Of Hawaii. (1999, June 1). University Of Hawaii Scientists Announce First Male Clone. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/1999/06/990601081911.htm
University Of Hawaii. "University Of Hawaii Scientists Announce First Male Clone." ScienceDaily. www.sciencedaily.com/releases/1999/06/990601081911.htm (accessed October 23, 2014).

Share This



More Plants & Animals News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Working Mother DIY: Pumpkin Pom-Pom

Working Mother DIY: Pumpkin Pom-Pom

Working Mother (Oct. 22, 2014) How to make a pumpkin pom-pom. Video provided by Working Mother
Powered by NewsLook.com
San Diego Zoo's White Rhinos Provide Hope for the Critically Endangered Species

San Diego Zoo's White Rhinos Provide Hope for the Critically Endangered Species

Reuters - Light News Video Online (Oct. 22, 2014) The pair of rare white northern rhinos bring hope for their species as only six remain in the world. Elly Park reports. Video provided by Reuters
Powered by NewsLook.com
Raw: Bear Cub Strolls Through Oregon Drug Store

Raw: Bear Cub Strolls Through Oregon Drug Store

AP (Oct. 22, 2014) Shoppers at an Oregon drug store were surprised by a bear cub scurrying down the aisles this past weekend. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Family Pleads for Pet Pig to Stay at Home

Family Pleads for Pet Pig to Stay at Home

AP (Oct. 22, 2014) The Johnson family lost their battle with the Chesterfield County, Virginia Planning Commission to allow Tucker, their pet pig, to stay in their home, but refuse to let the board keep Tucker away. (Oct. 22) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins