Featured Research

from universities, journals, and other organizations

Signs Of The Ancient Mariner: Scientists Locate Elements Implicated In Human Genetic Disorders

Date:
September 29, 1999
Source:
Cold Spring Harbor Laboratory
Summary:
In a study published in the September issue of Genome Research, Lawrence Reiter, James Lupski (Baylor College of Medicine), and colleagues use fluorescent imaging to locate 109 mariner elements across the human genome, revealing potential undiscovered links between these elements and other hereditary human diseases.

Chromosomes swap DNA to create variety in the gene pool, but disorders can result if the exchanged regions don't match up properly. Recent studies suggest genetic elements called mariner transposons stimulate such mismatching exchanges underlying disorders like Charcot-Marie-Tooth disease and hereditary neuropathy.

In a study published in the September issue of Genome Research, Lawrence Reiter, James Lupski (Baylor College of Medicine), and colleagues use fluorescent imaging to locate 109 mariner elements across the human genome, revealing potential undiscovered links between these elements and other hereditary human diseases.

The mariner transposon encodes for a protein that cleaves DNA and also acts as a cleavage target for this protein. Like all transposons, mariner elements can jump around the genome, excising and inserting themselves in different locations over time. These cleavage events may stimulate chromosomes to swap DNA, making the mariner a potential hotspot for genetic change - as well as genetic error.

To examine the occurrence of mariner across the human genome, Reiter and colleagues designed fluorescent probes that bind to mariner elements and applied these probes to whole human chromosomes. The chromosomes developed fluorescent bands revealing the locations of mariner elements, some of which correspond to sites of known genetic disorders such as growth hormone deficiency and hemophilia A.

This work provides the first, preliminary evidence that places mariner in the vicinity of these disparate human diseases. So it may be apt now to recall the words of Samuel Coleridge's ancient mariner: "And I had done a hellish thing/And it would work 'em woe."


Story Source:

The above story is based on materials provided by Cold Spring Harbor Laboratory. Note: Materials may be edited for content and length.


Cite This Page:

Cold Spring Harbor Laboratory. "Signs Of The Ancient Mariner: Scientists Locate Elements Implicated In Human Genetic Disorders." ScienceDaily. ScienceDaily, 29 September 1999. <www.sciencedaily.com/releases/1999/09/990929022428.htm>.
Cold Spring Harbor Laboratory. (1999, September 29). Signs Of The Ancient Mariner: Scientists Locate Elements Implicated In Human Genetic Disorders. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/1999/09/990929022428.htm
Cold Spring Harbor Laboratory. "Signs Of The Ancient Mariner: Scientists Locate Elements Implicated In Human Genetic Disorders." ScienceDaily. www.sciencedaily.com/releases/1999/09/990929022428.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins