Featured Research

from universities, journals, and other organizations

Antibiotic Resistance Investigations Indicate Both Good, Bad News

Date:
November 24, 1999
Source:
University Of Iowa
Summary:
The University of Iowa is reporting both good news and bad news on the war against antibiotic-resistant bacteria. Although one UI Health Care study shows there may be a potent, new drug to combat bacteria resistant to existing antibiotics, another investigation reveals that some strains of Staphylococcus aureus (S. aureus) have become antibiotic-resistant globe trotters, spreading throughout the world.

IOWA CITY, Iowa — The University of Iowa is reporting both good news and bad news on the war against antibiotic-resistant bacteria. Although one UI Health Care study shows there may be a potent, new drug to combat bacteria resistant to existing antibiotics, another investigation reveals that some strains of Staphylococcus aureus (S. aureus) have become antibiotic-resistant globe trotters, spreading throughout the world. S. aureus is the most common bacterial cause of human diseases, including infections of the lung, bloodstream, heart valves, skin and those infections caused by surgical wounds.

According to UI findings, a novel synthetic drug linezolid was universally active against all tested forms of staphylococci regardless of resistance patterns to other antibiotics. The new drug also inhibited all enterococci and was 100 percent effective against streptococci.

"Linezolid appears to be a very promising new antimicrobial agent," said Ronald Jones, M.D., UI professor of pathology. "We have not found any documented cases where the drug has not been effective."

Jones and Michael Pfaller, M.D., UI professor of pathology and public health, will present their findings at the 37th annual meeting of the Infectious Diseases Society of America to be held Nov. 18-21 in Philadelphia. The UI investigative team is the first, besides the manufacturer Pharmacia & Upjohn, to test the effectiveness of the drug.

"One of the most exciting potential uses for this new agent is the management of resistant Gram-positive infections," Pfaller said.

That potential may be even more important considering the findings that UI colleague Daniel Diekema, M.D., a UI pathology fellow and infectious diseases staff physician, will report at the same meeting.

According to the UI study led by Diekema, Pfaller and Jones, similar and sometimes identical antibiotic-resistant strains of S. aureus are popping up hundreds and thousands of miles apart, even across oceans.

"We demonstrated that there are numerous instances where bacterial strains were present at many different hospitals in the same region and at hospitals on different continents," Diekema explained.

The medical community has been using antibiotics to treat bacterial infections for more than

60 years. However, many bacterial strains have become immune to most of the available drugs meant to destroy the organisms. Much of this immunity, or resistance, is due to overuse of the drugs themselves.

In the study Diekema will present, the UI investigators wanted to find out the genetic relatedness of antibiotic resistant S. aureus strains in various areas of the world. The UI researchers also wanted to identify places where resistance was the highest. To conduct the probe, the UI team relied on the global network of 72 medical centers that participate in the SENTRY Antimicrobial Surveillance Program sponsored by Bristol-Myers Squibb. SENTRY is a joint effort between the UI and the Women's and Children's Hospital, Adelaide, Australia. The program is the first and only worldwide monitoring system for the spread, over time, of bacteria resistant to antibiotics.

"We did this particular study because it is very important to understand how these resistant strains are being spread around the world," Diekema said.

The findings, which showed that many of the resistant strains cross national borders and that the biggest resistance problem areas are located in Central and South America and in Asian-Pacific countries, are important as infectious disease control specialists attempt to combat the resistance, Diekema stressed.

"If resistance emerges within an individual hospital because of antibiotic use, then the best way to control that resistance is to crack down on antibiotic use," he said. "However, if very resistant strains are being spread widely between hospitals, then the best approach is to emphasize infection control practices. In the case of S. aureus, it looks like these resistant strains are very easily spread in hospitals, among hospitals and even across continents. What that means to us is that even though antibiotic control is important for this bacteria, even more important probably are good infection control practices."

University of Iowa Health Care describes the partnership between the UI College of Medicine and the UI Hospitals and Clinics and the patient care, medical education and research programs and services they provide.


Story Source:

The above story is based on materials provided by University Of Iowa. Note: Materials may be edited for content and length.


Cite This Page:

University Of Iowa. "Antibiotic Resistance Investigations Indicate Both Good, Bad News." ScienceDaily. ScienceDaily, 24 November 1999. <www.sciencedaily.com/releases/1999/11/991124070952.htm>.
University Of Iowa. (1999, November 24). Antibiotic Resistance Investigations Indicate Both Good, Bad News. ScienceDaily. Retrieved August 29, 2014 from www.sciencedaily.com/releases/1999/11/991124070952.htm
University Of Iowa. "Antibiotic Resistance Investigations Indicate Both Good, Bad News." ScienceDaily. www.sciencedaily.com/releases/1999/11/991124070952.htm (accessed August 29, 2014).

Share This




More Health & Medicine News

Friday, August 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com
How A 'Rule Of Thumb' Could Slow Down Drinking

How A 'Rule Of Thumb' Could Slow Down Drinking

Newsy (Aug. 28, 2014) A study suggests people who follow a "rule of thumb" when pouring wine dispense less than those who don't have a particular amount in mind. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins