Featured Research

from universities, journals, and other organizations

Researchers Find A Genetic Link Between Vascular Disease And A Common Human Herpes Virus

Date:
November 30, 1999
Source:
Oregon Health Sciences University
Summary:
For years, scientists have proposed a connection between a common herpes virus and vascular problems that occur in patients who have undergone an organ transplant or angioplasty procedure to clear clogged arteries. However, the reason behind this connection has remained a mystery. Now, researchers at Oregon Health Sciences University believe they have discovered a mechanism in the body responsible for this puzzling health problem.

Portland, Ore. -- For years, scientists have proposed a connection between a common herpes virus and vascular problems that occur in patients who have undergone an organ transplant or angioplasty procedure to clear clogged arteries. However, the reason behind this connection has remained a mystery. Now, researchers at Oregon Health Sciences University believe they have discovered a mechanism in the body responsible for this puzzling health problem. Their work will be published in the Nov. 24 issue of the journal Cell.

The research at OHSU centers on the human cytomegalovirus (CMV), a member of the herpes family, which has infected 50 to 85 percent of the adult population across the United States. The virus remains alive in the body for the rest of the carrier's life, but many hosts are unaware they are carriers. This is due to the fact that the virus normally remains dormant and does not cause major health problems unless a person has a suppressed immune system.

During the past 20 years, many studies have linked the virus to the development of atherosclerosis and other vascular diseases that occur in solid organ transplant recipients, or in patients who have undergone balloon angioplasty for clogged arteries.

A key part of these diseases involves the over-accumulation of smooth muscle cells in the artery wall, which can block blood flow in a vessel. CMV is often observed in these smooth muscle cells. Researchers at OHSU have uncovered evidence that a CMV gene called US28 stimulates the smooth muscle cells to migrate. Two proteins known as chemokines bind with US28 and direct the smooth muscle cells to areas of inflammation that may occur in atherosclerosis or vascular disease in transplant patients.

Dan Streblow, Ph.D., a postdoctoral fellow in microbiology and immunology at OHSU, is the principal author in the study along with co-authors Cecilia Soderberg, M.D., Ph.D., and Patsy Smith, M.S., in collaboration with Jeffery Vieira, Ph.D., at the University of Washington. Streblow calls the research a big step in understanding how viruses play a role in atherosclerosis. "It is quite rewarding to finally reveal a genetic link between CMV and vascular disease," said Streblow.

The senior author of the study, Jay Nelson, Ph.D., professor of molecular microbiology and immunology at OHSU, and director of OHSU's Vaccine and Gene Therapy Center, believes this work may provide hope for all patients at risk for vascular disease. "This work provides the smoking gun to explain the vast amount of correlative evidence linking CMV to the acceleration of vascular disease," said Nelson.

Portland-based Activated Cell Systems, L.L.C., which funded part of this project, believes that in the future this work could result in pharmaceuticals that block this process before it even starts.


Story Source:

The above story is based on materials provided by Oregon Health Sciences University. Note: Materials may be edited for content and length.


Cite This Page:

Oregon Health Sciences University. "Researchers Find A Genetic Link Between Vascular Disease And A Common Human Herpes Virus." ScienceDaily. ScienceDaily, 30 November 1999. <www.sciencedaily.com/releases/1999/11/991130063117.htm>.
Oregon Health Sciences University. (1999, November 30). Researchers Find A Genetic Link Between Vascular Disease And A Common Human Herpes Virus. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/1999/11/991130063117.htm
Oregon Health Sciences University. "Researchers Find A Genetic Link Between Vascular Disease And A Common Human Herpes Virus." ScienceDaily. www.sciencedaily.com/releases/1999/11/991130063117.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

EU Ministers and Experts Meet to Discuss Ebola Reponse

EU Ministers and Experts Meet to Discuss Ebola Reponse

AFP (Sep. 15, 2014) The European Commission met on Monday to coordinate aid that the EU can offer to African countries affected by the Ebola outbreak. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
Despite The Risks, Antibiotics Still Overprescribed For Kids

Despite The Risks, Antibiotics Still Overprescribed For Kids

Newsy (Sep. 15, 2014) A new study finds children are prescribed antibiotics twice as often as is necessary. Video provided by Newsy
Powered by NewsLook.com
FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com
Respiratory Virus Spreads To Northeast, Now In 21 States

Respiratory Virus Spreads To Northeast, Now In 21 States

Newsy (Sep. 14, 2014) The respiratory virus Enterovirus D68, which targets children, has spread from the Midwest to 21 states. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins