Featured Research

from universities, journals, and other organizations

Yale Researchers Identify Gene And Protein That Stops Spinal Cord And Brain Regrowth After Nervous System Injury

Date:
January 27, 2000
Source:
Yale University
Summary:
Reversing brain and spinal cord injuries may soon be possible with the discovery of a gene and protein responsible for stopping axon regrowth, Yale researchers say.

New Haven, Conn. -- Reversing brain and spinal cord injuries may soon be possible with the discovery of a gene and protein responsible for stopping axon regrowth, Yale researchers say.

Related Articles


Brain and spinal cord axons can grow after injury if provided with an adequate environment, but the natural adult brain environment contains substances which inhibit axon regeneration. One of these inhibitors is the Nogo protein.

"We have identified the gene and protein responsible for this Nogo activity," said Stephen M. Strittmatter, M.D., associate professor of neurology and of neurobiology at Yale School of Medicine. "Our work suggests that the Nogo protein is an important and selective blocker of axon regeneration in the brain after central nervous system injury."

Published in the January 27 issue of Nature, Strittmatter's study shows that Nogo protein generated in the laboratory stops axon growth. In addition, the protein is found exclusively in those areas of the brain which are most hostile to axon growth. Future experiments will determine whether this is the major inhibitor of axon regeneration in the brain or if it is one of several inhibitors.

After many adult nervous system injuries, the nerve cells survive but their connecting axons are severed and function is lost. Outside the brain and spinal cord, these connections usually grow back and recovery is excellent.

Inside the brain and spinal cord, very little axon regrowth occurs after injury and the clinical prognosis for recovery of function is poor. A clear example of this is human spinal cord injury.

In addition to identifying the gene and protein, the team also found that the inhibitory activity is localized to a discrete portion of Nogo. Because this inhibitory portion is less than 10 percent of the entire Nogo protein, Strittamatter says, the identification and design of inhibitors of Nogo action should be greatly facilitated.

"If those inhibitors based on Nogo can be developed, the failure of axon regeneration and functional recovery after many brain and spinal injuries might be reversed," said Strittmatter.

Strittmatter's research team in the Department of Neurology at Yale included Tadzia GrandPre and Fumio Nakamura, M.D. The work was completed in collaboration with Timothy Vartanian, M.D. of the Department of Neurology at Beth Israel Deaconess Medical Center Harvard Institutes of Medicine.


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Yale Researchers Identify Gene And Protein That Stops Spinal Cord And Brain Regrowth After Nervous System Injury." ScienceDaily. ScienceDaily, 27 January 2000. <www.sciencedaily.com/releases/2000/01/000127082302.htm>.
Yale University. (2000, January 27). Yale Researchers Identify Gene And Protein That Stops Spinal Cord And Brain Regrowth After Nervous System Injury. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2000/01/000127082302.htm
Yale University. "Yale Researchers Identify Gene And Protein That Stops Spinal Cord And Brain Regrowth After Nervous System Injury." ScienceDaily. www.sciencedaily.com/releases/2000/01/000127082302.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins