Featured Research

from universities, journals, and other organizations

Queen's Researchers Discover Cause Of Heart Failure After Surgery

Date:
February 10, 2000
Source:
Queen's University
Summary:
A collaboration between Queen's scientists and researchers at Johns Hopkins University has led to a significant discovery about the cause of sudden heart failure after open-heart surgery, a common occurrence that results in most heart patients having to spend a full day in intensive care following surgery and costing taxpayers millions of dollars every year in post-operative medical care.

A collaboration between Queen's scientists and researchers at Johns Hopkins University has led to a significant discovery about the cause of sudden heart failure after open-heart surgery, a common occurrence that results in most heart patients having to spend a full day in intensive care following surgery and costing taxpayers millions of dollars every year in post-operative medical care.

The work of Queen's researchers Dr. Jennifer Van Eyk, an assistant professor with the Dept. of Physiology, and Queen's graduate student Jason McDonough, in collaboration with Drs. Anne Murphy, David Kass and Eduardo Marban at John Hopkins, focuses on molecules linked to heart muscle contractions and contributes to a new understanding of how a problem at the molecular level can lead to a type of acquired heart failure.

Published last week in the journal Science, the study shows how a protein called troponin I that is a key part of a heart muscle cell's contracting "machinery" is damaged and how that leads to heart failure known as "cardiac stunning".

Last month, the research was picked by the American Heart Association for its list of top 10 research advances in heart disease and stroke in 1999.

"We are very excited about the role we have played in this study," says Dr. Van Eyk. "This points to new ways of preventing and treating this specific heart problem and also enhances our understanding of the more common type of chronic heart failure."

When blood flow to the heart is reduced or stopped, problems develop with the regulated contraction of the heart muscle which may persist even after flow has been re-established. The researchers at Queen's and Hopkins had independently demonstrated that a specific protein key to contraction of the heart is "clipped" (a small piece chopped off the end) even in mild cases of blood flow interruption. At Queen's, the Van Eyk laboratory went on to identify of the exact clip. This lead to the collaboration with the group from Johns Hopkins. In order determine that the faulty protein is sufficient to causes cardiac stunning, the researcher inserted the abnormal troponin I in into otherwise healthy mice and documented the development of reduced or stopped blood flow.

Simultaneously, the Queen's researchers were determining that these findings are applicable to humans. "Our laboratory was able to demonstrate that the protein is clipped in the heart muscle of patients having bypass surgery. This was achieved by analyzing small pieces of heart muscle obtained before and after coronary bypass surgery, thanks to samples provided by Dr. Glorianne Ropchan, cardio-thoracic surgeon at Kingston General Hospital," explains McDonough.

"Now that we know what is causing cardiac stunning, we might be able to decrease the amount of injury that occurs during bypass surgery and other relatively mild cardiac events. This opens up the possibility of new therapeutic approaches," says Dr. Van Eyk.

The Queen's research was funded by grants from the Heart and Stroke Foundation of Canada, Medical Research Council of Canada and National Institutes of Health.

Note: The original news release can be found here.


Story Source:

The above story is based on materials provided by Queen's University. Note: Materials may be edited for content and length.


Cite This Page:

Queen's University. "Queen's Researchers Discover Cause Of Heart Failure After Surgery." ScienceDaily. ScienceDaily, 10 February 2000. <www.sciencedaily.com/releases/2000/02/000210074552.htm>.
Queen's University. (2000, February 10). Queen's Researchers Discover Cause Of Heart Failure After Surgery. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2000/02/000210074552.htm
Queen's University. "Queen's Researchers Discover Cause Of Heart Failure After Surgery." ScienceDaily. www.sciencedaily.com/releases/2000/02/000210074552.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins