Featured Research

from universities, journals, and other organizations

University At Buffalo Researchers Develop Novel Way To Study Dynamics Of Receptor Proteins

Date:
February 22, 2000
Source:
University At Buffalo
Summary:
Structural biologists are learning what protein molecules look like in their stable-state end-points, but very little is known about the instantaneous journey from one state to the other. Researchers at the University at Buffalo, in the Feb. 17 issue of Nature, report a new way to study the dynamics of proteins as they pass through this transition state.

BUFFALO, N.Y. -- Proteins, the workhorses of human cells, exist primarily in two stable states: inactive and active. In order to perform their assigned tasks, they must be triggered to change into the active state.

Structural biologists are learning what protein molecules look like in their stable-state end-points, but very little is known about the instantaneous journey from one state to the other.

Researchers at the University at Buffalo, in the Feb. 17 issue of Nature, report a new way to study the dynamics of proteins as they pass through this transition state.

"To understand how a protein works, it is very important to understand how it moves and changes," said Anthony Auerbach, Ph.D., UB professor of physiology and biophysics, and senior author on the paper. Claudio Grosman, Ph.D., research assistant professor working with Auerbach, is the primary author.

"When we know how the protein moves, perhaps we can make it go faster or slower, or develop drugs to change the ratio of active-to-inactive states," Auerbach said.

The ability to intervene in the transition state eventually could be useful in such conditions as congenital myasthenia syndrome, in which molecules in muscle cells jump too quickly from one state to the other, causing damage to the cell and eventually interfering with movement, he noted.

Grosman and Auerbach have been working with a single protein molecule at the nerve-muscle synapse -- a receptor for the neurotransmitter acetylcholine. Using a standard technique called patch clamp, they have been able to obtain a "snapshot" of several regions of the receptor at the transition state -- the highest energy point between active and inactive states. Their results suggest there is a wave of structural change during receptor activation.

"The resulting map of this conformation wave provides empirical evidence that will serve as guide posts for scientists who will do the computer analysis of the transition state in the future," Auerbach said.

Ming Zhou, Ph.D., a former graduate student in the UB Department of Physiology and Biophysics, now at Rockefeller University, also participated in the research.


Story Source:

The above story is based on materials provided by University At Buffalo. Note: Materials may be edited for content and length.


Cite This Page:

University At Buffalo. "University At Buffalo Researchers Develop Novel Way To Study Dynamics Of Receptor Proteins." ScienceDaily. ScienceDaily, 22 February 2000. <www.sciencedaily.com/releases/2000/02/000222065206.htm>.
University At Buffalo. (2000, February 22). University At Buffalo Researchers Develop Novel Way To Study Dynamics Of Receptor Proteins. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2000/02/000222065206.htm
University At Buffalo. "University At Buffalo Researchers Develop Novel Way To Study Dynamics Of Receptor Proteins." ScienceDaily. www.sciencedaily.com/releases/2000/02/000222065206.htm (accessed September 18, 2014).

Share This



More Matter & Energy News

Thursday, September 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Stocks Hit All-Time High as Fed Holds Steady

Stocks Hit All-Time High as Fed Holds Steady

AP (Sep. 17, 2014) The Federal Reserve signaled Wednesday that it plans to keep a key interest rate at a record low because a broad range of U.S. economic measures remain subpar. Stocks hit an all-time high on the news. (Sept. 17) Video provided by AP
Powered by NewsLook.com
Space Race Pits Bezos Vs Musk

Space Race Pits Bezos Vs Musk

Reuters - Business Video Online (Sep. 16, 2014) Amazon CEO Jeff Bezos' startup will team up with Boeing and Lockheed to develop rocket engines as Elon Musk races to have his rockets certified. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
MIT's Robot Cheetah Unleashed — Can Now Run, Jump Freely

MIT's Robot Cheetah Unleashed — Can Now Run, Jump Freely

Newsy (Sep. 16, 2014) MIT developed a robot modeled after a cheetah. It can run up to speeds of 10 mph, though researchers estimate it will eventually reach 30 mph. Video provided by Newsy
Powered by NewsLook.com
Manufacturer Prints 3-D Car In Record Time

Manufacturer Prints 3-D Car In Record Time

Newsy (Sep. 15, 2014) Automobile manufacturer Local Motors created a drivable electric car using a 3-D printer. Printing the body only took 44 hours. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins