Featured Research

from universities, journals, and other organizations

Methamphetamine Abuse Linked To Long-Term Damage To Brain Cells

Date:
March 28, 2000
Source:
NIH-National Institute On Drug Abuse
Summary:
New research shows that those who use methamphetamine, often called "meth" or "speed," risk long-term damage to their brain cells similar to that caused by strokes or Alzheimer's disease.

New research shows that those who use methamphetamine, often called "meth" or "speed," risk long-term damage to their brain cells similar to that caused by strokes or Alzheimer's disease. In an article published in the March 28 issue of Neurology, scientists at the Harbor-UCLA Medical Center in Torrance, California, used magnetic resonance spectroscopy to take measurements of three parts of the brains of 26 participants who had used methamphetamine and then compared them with measurements of the same regions in the brains of 24 people who had no history of drug abuse.

Related Articles


"While the meth users in this study hadn't used the drug for some time--anywhere from two weeks to 21 months, this research strongly suggests that methamphetamine abuse causes harmful physical changes in the brain that can last for many months and perhaps longer after drug use has stopped," said Dr. Alan I. Leshner, Director, National Institute on Drug Abuse (NIDA).

In their study, Dr. Linda Chang and Dr. Thomas Ernst measured levels of brain chemicals that indicate whether brain cells are healthy or are diseased or damaged.

"We found abnormal brain chemistry in the methamphetamine users in all three brain regions we studied. In one of the regions, the amount of damage is also related to the history of drug use--those who had used the most methamphetamine had the strongest indications of cell damage," Dr. Chang said.

The researchers found that levels of one chemical marker, N-acetyl-aspartate, were reduced by at least five percent in the methamphetamine abusers. "Many diseases associated with brain cell loss or damage, such as Alzheimer's disease, stroke, and epilepsy, are also associated with reduced N-acetyl-aspartate," said Dr. Ernst. "Reduced concentrations of N-acetyl-aspartate in the drug users' brains suggest that long-term methamphetamine abuse results in loss or damage to neurons, the cells we use in thinking." Two other chemical markers, myo-inositol and choline-containing compounds, are associated with glial cells, which act to support neurons. "Methamphetamine abusers showed increases of 11 percent and 13 percent in levels of these markers compared with normal individuals," Dr. Ernst said. "This suggests an increased number or size of glial cells as a reaction to the injurious effects of methamphetamine."

The researchers, who received funding from NIDA, plan to conduct more extensive studies to determine if these brain changes caused by methamphetamine abuse might be reversed or corrected by treatment.

-----------------------------------------

The National Institute on Drug Abuse is a component of the National Institutes of Health, U.S. Department of Health and Human Services. NIDA supports more than 85 percent of the world's research on the health aspects of drug abuse and addiction. The Institute carries out a large variety of programs to ensure the rapid dissemination of research information and its implementation in policy and practice. Fact sheets on the health effects of drugs of abuse and other topics can be ordered free of charge in English and Spanish by calling NIDA Infofax at 1-888-NIH-NIDA (644-6432) or 1-888-TTY-NIDA (889-6432) for the deaf. These fact sheets and further information on NIDA research and other activities can be found on the NIDA home page at http://www.drugabuse.gov.


Story Source:

The above story is based on materials provided by NIH-National Institute On Drug Abuse. Note: Materials may be edited for content and length.


Cite This Page:

NIH-National Institute On Drug Abuse. "Methamphetamine Abuse Linked To Long-Term Damage To Brain Cells." ScienceDaily. ScienceDaily, 28 March 2000. <www.sciencedaily.com/releases/2000/03/000328084630.htm>.
NIH-National Institute On Drug Abuse. (2000, March 28). Methamphetamine Abuse Linked To Long-Term Damage To Brain Cells. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2000/03/000328084630.htm
NIH-National Institute On Drug Abuse. "Methamphetamine Abuse Linked To Long-Term Damage To Brain Cells." ScienceDaily. www.sciencedaily.com/releases/2000/03/000328084630.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Mind & Brain News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Tryptophan Isn't Making You Sleepy On Thanksgiving

Tryptophan Isn't Making You Sleepy On Thanksgiving

Newsy (Nov. 27, 2014) — Tryptophan, a chemical found naturally in turkey meat, gets blamed for sleepiness after Thanksgiving meals. But science points to other culprits. Video provided by Newsy
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com
Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) — Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) — Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins