Featured Research

from universities, journals, and other organizations

New Polymer Shows Promise Against Ovarian Cancer

Date:
March 30, 2000
Source:
American Chemical Society
Summary:
The first synthetic rubber that kills bacteria and other pathogenic organisms on contact was described here today at the 219th national meeting of the American Chemical Society, the world’s largest scientific society. The material — whose killing power is renewable — proved effective in laboratory tests against Staphylococcus aureus and other major sources of hospital infections.

Effectiveness in Lab Tests Unexpected

SAN FRANCISCO, March 28 — A new polymer derived from an antibacterial drug has unexpectedly and dramatically inhibited the growth of ovarian cancer cell lines previously thought to be resistant to drugs, according to researchers at Florida Atlantic University in Boca Raton.

Both cell lines were obtained from ovarian cancer patients previously treated by conventional chemotherapy, including the drugs cytoxan, adriamycin and cisplatin. The new polymer-drug combination inhibited the growth of one cancer cell line by 97 percent and another by 80 percent.

The findings were presented here today at the 219th national meeting of the American Chemical Society, the world’s largest scientific society. The weeklong meeting is expected to attract about 20,000 scientists from around the world.

The investigation, carried out by Charles Carraher, Ph.D., and Deborah Siegmann-Louda, Ph.D., involves modifying existing drugs by incorporating them in metal-containing polymers. In this case, the antibacterial drug cephalexin and a polymer containing tin were used. By itself, cephalexin — marketed under the names Keflex and Keftabis — not active against the cell lines tested, Carraher notes.

The new polymer’s effectiveness makes it a potential “candidate as a last-defense cancer drug,” according to the researchers.

Why the polymer is effective remains a mystery. But there appears to be a synergistic effect from the metal, according to Carraher: “When you make polymers without the metals, as far as we can tell, you don’t get much activity.”

The next step is to vary the metal and see if that has any effect on the cancer, he says. In addition to tin, the researchers have made polymers combining cephalexin with arsenic, alimony and bismuth; they are now being tested.

Carraher calls the findings “exciting,” but is quick to add a note of caution: “Nothing is a miracle cure.” More testing is needed, including animal studies. Still, Carraher believes the cell line findings are “promising” — enough so, he says, that he is reallocating resources from other research projects in his lab.

Dr. Carraher is Professor, Department of Chemistry and Biochemistry, Florida Atlantic University. He also is Associate Director, Florida Center forEnvironmental Studies.

Dr. Siegmann-Louda is Associate Professor, Department of Chemistry and Biochemistry, Florida Atlantic University.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Cite This Page:

American Chemical Society. "New Polymer Shows Promise Against Ovarian Cancer." ScienceDaily. ScienceDaily, 30 March 2000. <www.sciencedaily.com/releases/2000/03/000329081511.htm>.
American Chemical Society. (2000, March 30). New Polymer Shows Promise Against Ovarian Cancer. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2000/03/000329081511.htm
American Chemical Society. "New Polymer Shows Promise Against Ovarian Cancer." ScienceDaily. www.sciencedaily.com/releases/2000/03/000329081511.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins