Featured Research

from universities, journals, and other organizations

Cat Allergy Sufferers Find Relief In Asthma Drug

Date:
April 28, 2000
Source:
Cat Allergy Sufferers Find Relief In Asthma Drug
Summary:
Scientists at Johns Hopkins have found that individuals who have the misfortune to be allergic to cats can find welcome relief and protection from symptoms in one of a new class of drugs already known to help other asthmatics.

Scientists at Johns Hopkins have found that individuals who have the misfortune to be allergic to cats can find welcome relief and protection from symptoms in one of a new class of drugs already known to help other asthmatics.

Results of the Hopkins research published in the April issue of the Journal of Allergy and Clinical Immunology show that zafirlukast not only prevents wheezing and shortness of breath, but also the itchy, runny, swollen noses triggered by allergens in cat dander.

"This drug has the added advantage of providing some relief for the nose as well as the chest," says Robert Wood, M.D., associate professor of pediatrics. "It's especially appealing because it is not a steroid and is given in pill form."

Zafirlukast is one of a relatively new class of asthma medicines known as leukotriene antagonists. These drugs block chemicals released by lung cells that are responsible for allergy symptoms. Because the drug has been very successful in treating asthma in adults and children, Hopkins researchers tested its potential to stop allergic reactions to cats.

The researchers enlisted 18 individuals with cat allergies and randomly assigned them to receive one week each of zafirlukast or placebo. Subjects volunteered to endure a one-hour stay in a specially designed "cat challenge room." This carpeted room, home to a couple of house cats, contained bedding that was shaken right before a study volunteer entered the habitat. "The room provides an extremely intense cat exposure, 10 to 100 times the level of allergens you would find in the home," says Wood.

While in the cat challenge room, the volunteers scored, on a scale of 1 to 3, the severity of their symptoms every five minutes. Researchers also tested the individuals' pulmonary function every 15 minutes and measured swelling in the back of the nose.

Zafirlukast significantly reduced the number of lung and nasal allergic symptoms individuals experienced when exposed to cats. Three of the 18 subjects had mild adverse effects such as diarrhea, nausea and mouth dryness during treatment with the drug.

"In some people, this drug was dramatically effective, and people don't have to rely on using their inhalers," says Wood.

Allergy is the most widespread chronic condition in the world, and sensitivity to animals is one of the most common causes of allergy. More people are allergic to cats than dogs, and in the United States, cat allergies affect between 5 percent and 10 percent of the population.

Other authors of the study are Wanda Phipatanakul, M.D., Peyton Eggleston, M.D., and Mary Kay Conover-Walker from the Division of Allergy and Immunology, Department of Pediatrics at the Johns Hopkins School of Medicine; Jana Kesavanathan, Ph.D., from the Division of Environmental Health Sciences at the Johns Hopkins School of Public Health; and Dennis Sweitzer, Ph.D., from AstraZeneca Pharmaceuticals. The study was funded by AstraZeneca Pharmaceuticals, makers of the drug, and by the National Institutes of Health.


Story Source:

The above story is based on materials provided by Cat Allergy Sufferers Find Relief In Asthma Drug. Note: Materials may be edited for content and length.


Cite This Page:

Cat Allergy Sufferers Find Relief In Asthma Drug. "Cat Allergy Sufferers Find Relief In Asthma Drug." ScienceDaily. ScienceDaily, 28 April 2000. <www.sciencedaily.com/releases/2000/04/000428074407.htm>.
Cat Allergy Sufferers Find Relief In Asthma Drug. (2000, April 28). Cat Allergy Sufferers Find Relief In Asthma Drug. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2000/04/000428074407.htm
Cat Allergy Sufferers Find Relief In Asthma Drug. "Cat Allergy Sufferers Find Relief In Asthma Drug." ScienceDaily. www.sciencedaily.com/releases/2000/04/000428074407.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com
Tooth Plaque Provides Insight Into Diets Of Ancient People

Tooth Plaque Provides Insight Into Diets Of Ancient People

Newsy (July 19, 2014) Research on plaque from ancient teeth shows that our prehistoric ancestor's had a detailed understanding of plants long before developing agriculture. Video provided by Newsy
Powered by NewsLook.com
Contaminated Water Kills 3 Babies in South African Town

Contaminated Water Kills 3 Babies in South African Town

AFP (July 18, 2014) Contaminated water in South Africa's northwestern town of Bloemhof kills three babies and hospitalises over 500 people. The incident highlights growing fears over water safety in South Africa. Duration: 02:22 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins