Featured Research

from universities, journals, and other organizations

Gene Responsible For Aging Found In Yeast

Date:
May 29, 2000
Source:
American Society For Microbiology
Summary:
Could yeast show us the secrets to the aging process? Researchers have discovered that the secret to slowing the aging process in yeast is calorie restriction and have also identified the gene involved, a finding that could have potential for the development of anti-aging therapies.

May 24, 2000 -- Could yeast show us the secrets to the aging process? Researchers have discovered that the secret to slowing the aging process in yeast is calorie restriction and have also identified the gene involved, a finding that could have potential for the development of anti-aging therapies. They report their research today at the 100th General Meeting of the American Society for Microbiology.

Caloric restriction, which is the reduction of caloric intake without malnutrition, is a time proven method for extending the life span of mammals and postponing the manifestations of aging, including both functional decline and age-related diseases. Much is know about the physiological changes that occur in animals subjected to caloric restriction, but molecular mechanisms involved in this phenomenon are poorly understood because of the lack of workable experimental models.

"The efficacy of caloric restriction in retarding the aging process points to the importance of nutritional and metabolic mechanisms in aging," says Dr. Michal Jazwinski of the Louisiana State University. "If we could elucidate these mechanisms, it is likely that we would be able to develop relatively simple interventions that would alleviate the ravages of the aging process and improve quality of life in the later years in humans."

Dr. Jazwinski has developed the yeast Saccharomyces cerevisiae as an experimental model for the molecular analysis of the aging process. He has discovered that manipulating the nutritional intake of yeast cells can increase their life spans, providing a useful model for the molecular analysis of caloric restriction. Not only has Dr. Jazwinski shown that caloric restriction extends the life span of these cells but also postpones many of the physical manifestations of aging.

In a related study, Dr. Leonard Guarente of the Massachusetts Institute of Technology announced that his lab has identified a gene, SIR2, which regulates the life span of yeast. The gene is responsible for the production of a protein, Sir2, and the higher the level of this protein, the longer the life span of yeast cells. Sir2 is responsible for a process called genomic silencing that Dr. Guarente believes helps slow the aging process. However, it requires help of another compound, the level of which is determined by metabolic rate, to do this.

"Our findings thus provide a model for aging that is universal and explains how calorie restriction extends life span," says Dr. Guarente. "We believe that these studies could lead to the development of a drug that intervenes to strengthen the Sir2-silencing process and provides the benefits of calorie restriction without the extreme difficulty of the regimen itself."

###

This release is a summary of a presentation from the 100th General Meeting of the American Society for Microbiology, May 21-25, 2000, in Los Angeles. Additional information on these and other presentations at the 100th ASM General Meeting can be found online at http://www.asmusa.org/pcsrc/gm2000/presskit.htm or by contacting Jim Sliwa jsliwa@asmusa.org in the ASM Office of Communications.


Story Source:

The above story is based on materials provided by American Society For Microbiology. Note: Materials may be edited for content and length.


Cite This Page:

American Society For Microbiology. "Gene Responsible For Aging Found In Yeast." ScienceDaily. ScienceDaily, 29 May 2000. <www.sciencedaily.com/releases/2000/05/000529093001.htm>.
American Society For Microbiology. (2000, May 29). Gene Responsible For Aging Found In Yeast. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2000/05/000529093001.htm
American Society For Microbiology. "Gene Responsible For Aging Found In Yeast." ScienceDaily. www.sciencedaily.com/releases/2000/05/000529093001.htm (accessed October 2, 2014).

Share This



More Health & Medicine News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Robotic Hair Restoration

Robotic Hair Restoration

Ivanhoe (Oct. 1, 2014) A new robotic procedure is changing the way we transplant hair. The ARTAS robot leaves no linear scarring and provides more natural results. Video provided by Ivanhoe
Powered by NewsLook.com
Insertable Cardiac Monitor

Insertable Cardiac Monitor

Ivanhoe (Oct. 1, 2014) A heart monitor the size of a paperclip that can save your life. The “Reveal Linq” allows a doctor to monitor patients with A-Fib on a continuous basis for up to 3 years! Video provided by Ivanhoe
Powered by NewsLook.com
Attacking Superbugs

Attacking Superbugs

Ivanhoe (Oct. 1, 2014) Two weapons hospitals can use to attack superbugs. Scientists in Ireland created a new gel resistant to superbugs, and a robot that can disinfect a room in minutes. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins