Featured Research

from universities, journals, and other organizations

UBC Researchers Find Key To Reducing Inflammation

Date:
August 21, 2000
Source:
University Of British Columbia
Summary:
A protein that reduces inflammation has been discovered by a group of UBC researchers. The finding, to be reported Friday in the journal Science, may pave the way for new treatments of chronic inflammatory diseases such as arthritis, gingivitis, and lung disease.

A protein that reduces inflammation has been discovered by a group of UBC researchers. The finding, to be reported Friday in the journal Science, may pave the way for new treatments of chronic inflammatory diseases such as arthritis, gingivitis, and lung disease.

The Canadian research team led by Prof. Chris Overall at UBC's Faculty of Dentistry, discovered how one of the natural signals - MCP-3 -- the human body uses to turn off inflammation while studying how cancer cells spread.

"MCP-3 is like a traffic signal with a green and red light that tells the macrophages - white blood cells that rid the body of damaged tissue -- when and where to go," said Overall.

"Like any accident, it is important to get help, but when everything is fixed, the body then needs to be told to stop sending more `ambulances' to the problem spot, or else things clog up and break down again."

Overall explains that in chronic diseases like gingivitis or arthritis something goes wrong with the signals and the flow of white blood cells continues, leading to chronic inflammation and long-term tissue damage.

Angus McQuibban, a UBC biochemistry doctoral student working in Overall's lab, discovered a new form of MCP-3 that halts the flow of the white blood cells. He found that an enzyme called gelatinase made during inflammation trimmed the end of MCP-3 molecules and led to the new form of the protein.

McQuibban likens it to shooting out the green light on a traffic signal. "There is now no more signal. But we had a bigger surprise to find that not only was the `green light' removed, but that the `red light' then came on. Now the movement of these cells was stopped."

Tests revealed that there was a 40 per cent reduction in inflammation when the new form of MCP-3 was administered. Prof. Ian Clark-Lewis at UBC's Biomedical Research Centre synthesized the new form of MCP-3 for testing by Prof. Chris McCullouch at the University of Toronto's Faculty of Dentistry.

"What we are trying to do now is to work out how these signals go wrong in diseases like cancer, arthritis and periodontitis with the hope we can understand in molecular detail these very complicated processes that may lead to new drug discoveries," said Overall.

In the meantime, the new form of MCP-3 has been patented at UBC and is being evaluated as a new anti-inflammatory drug.

The team's research is being funded by a grant from the National Cancer Institute of Canada and the Canadian Cancer Society.


Story Source:

The above story is based on materials provided by University Of British Columbia. Note: Materials may be edited for content and length.


Cite This Page:

University Of British Columbia. "UBC Researchers Find Key To Reducing Inflammation." ScienceDaily. ScienceDaily, 21 August 2000. <www.sciencedaily.com/releases/2000/08/000817093959.htm>.
University Of British Columbia. (2000, August 21). UBC Researchers Find Key To Reducing Inflammation. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2000/08/000817093959.htm
University Of British Columbia. "UBC Researchers Find Key To Reducing Inflammation." ScienceDaily. www.sciencedaily.com/releases/2000/08/000817093959.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins