Featured Research

from universities, journals, and other organizations

New Dental Anesthetic Promises Better Pain Control For Patients

Date:
September 21, 2000
Source:
Ohio State University
Summary:
An Ohio State University researcher has patented a dental anesthetic formula that's considerably more effective than any currently available.

COLUMBUS, Ohio -- An Ohio State University researcher has patented a dental anesthetic formula that's considerably more effective than any currently available.

The composition is a mix of a local anesthetic agent and a sugar alcohol. The alcohol opens the protective covering of sensory nerves, allowing the anesthetic agent to enter the innermost parts of the nerves it is meant to numb.

Researchers found that the new composition could completely numb the anesthetized region in about 90 percent of cases, as opposed to about 50 percent of cases using only the local anesthesia in the standard dosage.

"Using the sugar alcohol makes local anesthesia more effective," said Al Reader, inventor of the composition, a professor of dentistry and director of Ohio State's Advanced Endodontics Program.

Reader believes the principle behind his new formulation could be applied to improve anesthesia for a range of surgeries.

Reader tested different versions of his formulation - a mixof lidocaine (a local anesthetic) and mannitol (the sugar alcohol) in different proportions - on more than 200 people. The best results came from a concoction of mannitol and about 64 milligrams of lidocaine - roughly double the amount currently used by dental anesthetists. With that combination, about 90 percent of patients were able to achieve complete numbness.

Reader and his colleagues studied the efficacy of the composition on study participants by delivering mild shocks to the base of the tooth - the region that had been numbed - and evaluating the patient's response. If the patient did not feel anything up to a certain voltage, the case was recorded as total anesthesia. "This would mean the patient will not feel a thing during a dental procedure such as drilling," Reader explained.

When Reader increased the mannitol's concentration in the composition beyond a certain limit, some of the anesthetized subjects felt sore in the jaw. "Although mannitol is inert and does not interact chemically with either the anesthetic agent or body fluids, high concentrations of it tend to remove water from the surrounding tissue. That causes an irritation," he said. "That's how we arrived at the upper limit."

The idea that mannitol could help increase the efficacy of local anesthetics came to Reader several years ago when he learned that doctors were using the compound to get chemotherapeutic agents across the blood-brain barrier in patients with brain tumors. Since the barrier is nature's mechanism to prevent toxins in the blood from crossing into the brain, it does not allow drug molecules to reach either.

"Dental surgeons are taught that if patients have not been effectively numbed, it's because of an inaccurate injection - which, in turn, is because the anesthetist hasn't understood the patient's anatomy," Reader said. "So I studied the anatomy. But it didn't help. We gave more anesthetic, but that didn't help either." Reader also tried numbing additional nerves at the base of the tooth to increase the numbing effect. "Nothing worked," he said. "That's when I decided to try mannitol."

Reader is discussing commercialization plans with private companies. The composition will have to undergo further clinical trials for FDA approval, but mannitol is routinely used in medicine, so he expects speedy approval.


Story Source:

The above story is based on materials provided by Ohio State University. Note: Materials may be edited for content and length.


Cite This Page:

Ohio State University. "New Dental Anesthetic Promises Better Pain Control For Patients." ScienceDaily. ScienceDaily, 21 September 2000. <www.sciencedaily.com/releases/2000/09/000921071949.htm>.
Ohio State University. (2000, September 21). New Dental Anesthetic Promises Better Pain Control For Patients. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2000/09/000921071949.htm
Ohio State University. "New Dental Anesthetic Promises Better Pain Control For Patients." ScienceDaily. www.sciencedaily.com/releases/2000/09/000921071949.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins