Featured Research

from universities, journals, and other organizations

Progressor Chimpanzees Could Reveal Mechanism For Resisting AIDS

Date:
September 22, 2000
Source:
Emory University Health Sciences Center
Summary:
Three HIV-positive chimpanzees that are progressing to AIDS could provide insight into how the disease develops and might be averted, according to research conducted at the Yerkes Regional Primate Research Center of Emory University and published in the October issue (Vol. 182, No. 4) of The Journal of Infectious Diseases.

ATLANTA September 13, 2000 - Three HIV-positive chimpanzees that are progressing to AIDS could provide insight into how the disease develops and might be averted, according to research conducted at the Yerkes Regional Primate Research Center of Emory University and published in the October issue (Vol. 182, No. 4) of The Journal of Infectious Diseases.

The chimpanzees were originally inoculated with multiple strains of HIV some 15 years ago. All of the animals remain clinically healthy, but show evidence of abnormal immune function typical of progressive HIV infection.

Although chimpanzees are susceptible to HIV infection, they normally do not develop AIDS. In 1996, Dr. Francis Novembre and other scientists at the Yerkes Research Center described the first case of AIDS ever reported in a chimpanzee. That animal (C499) was housed with other HIV positive chimpanzees, including two of the three chimpanzees that are currently progressing to AIDS. Yerkes scientists are conducting genetic analyses to determine whether C499 transmitted his particular subtype of HIV to his companions.

The progressor chimps are among a group of ten HIV-positive chimpanzees that have been regularly monitored since the mid-1980s. Six of the chimps have displayed stable chronic HIV infection without signs of progressing to AIDS. C499 was euthanized in 1996 after developing complications from AIDS.

The Yerkes team, led by Dr. Shawn O'Neil, has found that virologic and immunologic changes among the progressor chimpanzees closely resemble those seen in human progressors, most notably high viral loads and profound reductions in CD4+ T lymphocytes. Likewise, the progressor chimpanzees have displayed evidence of chronic immune activation, another key marker of HIV progression in people.

"The conspicuous absence of immune activation in most HIV-infected chimpanzees has been proposed to explain the relative resistance of this species to the development of AIDS," said O'Neil. "These data suggest that chronic immune activation is important for HIV pathogenesis in chimpanzees, as it is in people."

Scientists believe that chimpanzees serve as the natural reservoir for HIV, and that they have adapted to HIV infection and developed resistance to the virus through natural selection. The HIV pandemic is thought to have originated through cross-species transmission of HIV from chimpanzees to people in West Africa. According to O'Neil, the discovery of the three progressor chimps presents an unique opportunity to identify the evolutionary mechanisms that normally protect chimpanzees from AIDS a mystery that continues to elude scientists.

"Aside from humans, chimpanzees are the only animals that are consistently susceptible to HIV infection," explained O'Neil. "But in most studies, chimpanzees have not developed AIDS. This group of progressor chimpanzees provides an important yardstick against which we can compare long-term nonprogressor (LTNPs) chimps. If we can determine what is different about these three chimps, we may be able to determine what normally protects these animals from AIDS."

O'Neil believes such a finding could have significant implications for the development of an HIV vaccine and new treatments for AIDS. Despite the scientific value of the progressor chimpanzees, O'Neil said that there are no plans to infect additional chimpanzees.

Like most chimpanzees, a small cohort of HIV-positive people do not develop AIDS. Compared to those who progress to AIDS, LTNP people generally maintain substantially lower levels of virus in plasma, normal, stable numbers of CD4+ T cells, and vigorous antiviral immune responses.

Yerkes scientists, however, have identified a compelling contrast between LTNP chimpanzees and LTNP people. LTNP chimpanzees maintain normal numbers of T-cells and levels of immune activation comparable to HIV-negative chimps. Human LTNPs, on the other hand, have an elevated level of immune activation compared to people who are HIV negative.

"This discrepancy could reflect fundamental differences in the mechanisms used to control HIV infection between an evolutionarily adapted host and an outlier population of a non-adapted host," said O'Neil.

The Yerkes Regional Primate Research Center holds to strict standards of care and treatment of animals established by the United States Department of Agriculture, National Institutes of Health, and professional oversight bodies. Personnel who work with HIV-infected chimpanzees also follow established biohazard guidelines to ensure their safety.

###

In addition to O'Neil and Novembre, authors of the Yerkes study that appeared in The Journal of Infectious Diseases include Drs. Clyde Hart, Daniel Anderson, James Herndon, and Harold McClure. Additional authors were Anne Brodie Hill, Carolyn Suwyn, Tammy Evans-Strickfaden, and Michelle Saucier.

The full text of the study is available at: http://www.emory.edu/WHSC/YERKES/newsroom/oneil.pdf.The research was funded by the National Institutes of Health.


Story Source:

The above story is based on materials provided by Emory University Health Sciences Center. Note: Materials may be edited for content and length.


Cite This Page:

Emory University Health Sciences Center. "Progressor Chimpanzees Could Reveal Mechanism For Resisting AIDS." ScienceDaily. ScienceDaily, 22 September 2000. <www.sciencedaily.com/releases/2000/09/000921072605.htm>.
Emory University Health Sciences Center. (2000, September 22). Progressor Chimpanzees Could Reveal Mechanism For Resisting AIDS. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2000/09/000921072605.htm
Emory University Health Sciences Center. "Progressor Chimpanzees Could Reveal Mechanism For Resisting AIDS." ScienceDaily. www.sciencedaily.com/releases/2000/09/000921072605.htm (accessed August 27, 2014).

Share This




More Health & Medicine News

Wednesday, August 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Predicting Heart Transplant Rejection With a Blood Test

Predicting Heart Transplant Rejection With a Blood Test

Ivanhoe (Aug. 27, 2014) Now a new approach to rejection of donor organs could change the way doctors predict transplant rejection…without expensive, invasive procedures. Video provided by Ivanhoe
Powered by NewsLook.com
Better Braces That Vibrate

Better Braces That Vibrate

Ivanhoe (Aug. 27, 2014) The length of time you have to keep your braces on could be cut in half thanks to a new device that speeds up the process. Video provided by Ivanhoe
Powered by NewsLook.com
Smartphone App Tracks Your Heart Rate

Smartphone App Tracks Your Heart Rate

Ivanhoe (Aug. 27, 2014) A new app that can track your heart rate 24/7 is available for download in your app store and its convenience could save your life. Video provided by Ivanhoe
Powered by NewsLook.com
Stroke in Young Adults

Stroke in Young Adults

Ivanhoe (Aug. 27, 2014) A stroke can happen at any time and affect anyone regardless of age. This mother chose to give her son independence and continue to live a normal life after he had a stroke at 18 years old. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins