Featured Research

from universities, journals, and other organizations

Researchers Battle Drug-Resistant HIV On Promising New Ground

Date:
September 26, 2000
Source:
American Chemical Society
Summary:
Researchers believe they have found a promising new battleground for HIV, the virus that causes AIDS: a portion of the virus that is unaffected by its myriad mutations.

Researchers believe they have found a promising new battleground for HIV, the virus that causes AIDS: a portion of the virus that is unaffected by its myriad mutations. The findings are described in the September 26 issue of Biochemistry, a peer-reviewed journal of the American Chemical Society, the world's largest scientific society.

Finding a spot unaffected by the billions of variations the virus can generate represents a great opportunity for preventing the virus's ability to spread, according to Virendranath Pandey, who led the research team at the New Jersey Medical School in Newark, New Jersey. The researchers have also created a way - in test tube studies - to block the reactions that allow the virus to reproduce itself.

Located in the center of a U-shaped loop inside HIV-affected cells, the site interacts with a protein necessary for the spread of the virus, Pandey explained. If the interaction can be prevented, the virus will not have a chance to spread or develop resistance to drugs, he said.

"The implications of these findings are that inhibition of this vital process will block the replication of the virus, thereby arresting the disease," Pandey said. "These results suggest that [this treatment] may be a potentially attractive therapy."

The researchers bonded a synthetic form of DNA - called PNA [polyamide nucleic acid] - to the virus's genetic structure. This prevented a protein called "Tat" from activating the process that spreads the virus from cell to cell. If the Tat protein is blocked, the virus cannot replicate itself.

PNA can be tailored specifically to fight HIV and is resistant to many of the body's defenses to break it down, according to Pandey. "This approach has great promise," he said. "I am very optimistic that if we are able to find a delivery system for this treatment, this approach may be useful to patients suffering from HIV infection."

This research was supported by grants from the National Institute of Allergy and Infectious Diseases, a division of the U.S. National Institutes of Health.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Cite This Page:

American Chemical Society. "Researchers Battle Drug-Resistant HIV On Promising New Ground." ScienceDaily. ScienceDaily, 26 September 2000. <www.sciencedaily.com/releases/2000/09/000926072245.htm>.
American Chemical Society. (2000, September 26). Researchers Battle Drug-Resistant HIV On Promising New Ground. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2000/09/000926072245.htm
American Chemical Society. "Researchers Battle Drug-Resistant HIV On Promising New Ground." ScienceDaily. www.sciencedaily.com/releases/2000/09/000926072245.htm (accessed October 2, 2014).

Share This



More Health & Medicine News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Robotic Hair Restoration

Robotic Hair Restoration

Ivanhoe (Oct. 1, 2014) A new robotic procedure is changing the way we transplant hair. The ARTAS robot leaves no linear scarring and provides more natural results. Video provided by Ivanhoe
Powered by NewsLook.com
Insertable Cardiac Monitor

Insertable Cardiac Monitor

Ivanhoe (Oct. 1, 2014) A heart monitor the size of a paperclip that can save your life. The “Reveal Linq” allows a doctor to monitor patients with A-Fib on a continuous basis for up to 3 years! Video provided by Ivanhoe
Powered by NewsLook.com
Attacking Superbugs

Attacking Superbugs

Ivanhoe (Oct. 1, 2014) Two weapons hospitals can use to attack superbugs. Scientists in Ireland created a new gel resistant to superbugs, and a robot that can disinfect a room in minutes. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins