Featured Research

from universities, journals, and other organizations

Genetically Engineered Hemoglobin Brings Artificial Blood A Step Closer

Date:
November 7, 2000
Source:
American Chemical Society
Summary:
Using genetic engineering techniques, researchers have created artificial hemoglobin that could someday alleviate perennial blood bank shortages. Hemoglobin - the vital component that carries life-supporting oxygen through the body - could be used in artificial blood transfused during surgeries and transplants, said Chien Ho, lead researcher from Carnegie Mellon University in Pittsburgh, Pa.

Using genetic engineering techniques, researchers have created artificial hemoglobin that could someday alleviate perennial blood bank shortages. The achievement is reported in the November 21 issue of Biochemistry, a peer-reviewed journal of the American Chemical Society, the world's largest scientific society.

Hemoglobin - the vital component that carries life-supporting oxygen through the body - could be used in artificial blood transfused during surgeries and transplants, said Chien Ho, lead researcher from Carnegie Mellon University in Pittsburgh, Pa. The method described in the research was used to produce small amounts of hemoglobin in a laboratory and needs to be improved, said Ho. But he believes the product is likely to be part of an eventual blood substitute.

Neither artificial blood nor its components are currently available. Several potential blood substitutes are being investigated, all of which incrementally advance development of an oxygen carrier, necessary for synthetic blood that could be safely used by people, Ho said. Because the population is aging and demand for blood is increasing - for surgeries, transfusions and to treat blood disorders - the need for a substitute is becoming urgent.

"There is an SOS for blood right now and that demand will only grow in the future," Ho said. "I am very excited about this research as a potential candidate in a blood substitute system. It shows great potential as a successful oxygen carrier, and is something that could realistically be used in people one day."

The researchers overcame problems that have plagued previous attempts to create oxygen carriers by building mutations into the hemoglobin molecule to enhance functioning. They allow it to act just like the hemoglobin molecule in regular human blood, Ho said. But like human blood, artificial hemoglobin would have to be replenished frequently.

Another approach to making artificial hemoglobin is needed to provide sufficient amounts for use in people. For example, pigs or other animals could be used to produce hemoglobin in bulk, Ho said.

Different types of hemoglobin can be designed using the same techniques, Ho said. For example, they might be tailored to meet specific medical requirements for afflictions like sickle-cell anemia and other blood-related disorders.

Some 4 million Americans receive transfusions of whole blood annually, including an estimated 3 million surgery patients, according to the American Association of Blood Banks. Approximately 13 million units of blood are donated each year, according to 2000 statistics compiled by the association.

The research cited above was funded by research grants from the National Institutes of Health and the American Heart Association.

Chien Ho, Ph.D., is a professor in the department of biological sciences at Carnegie Mellon University in Pittsburgh, Pa.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Cite This Page:

American Chemical Society. "Genetically Engineered Hemoglobin Brings Artificial Blood A Step Closer." ScienceDaily. ScienceDaily, 7 November 2000. <www.sciencedaily.com/releases/2000/11/001107070452.htm>.
American Chemical Society. (2000, November 7). Genetically Engineered Hemoglobin Brings Artificial Blood A Step Closer. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2000/11/001107070452.htm
American Chemical Society. "Genetically Engineered Hemoglobin Brings Artificial Blood A Step Closer." ScienceDaily. www.sciencedaily.com/releases/2000/11/001107070452.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins