Featured Research

from universities, journals, and other organizations

Gene Mutations Found That Lead To Prostate Cancer In Mice New Mouse Model Developed To Study The Disease

Date:
February 9, 2001
Source:
Memorial Sloan-Kettering Cancer Center
Summary:
Researchers at Memorial Sloan-Kettering Cancer Center (MSKCC) report in the February issue of Nature Genetics that inactivation of just one copy of a gene called PTEN and both copies of a gene called p27 leads to prostate cancer in mice 100 percent of the time.

Researchers at Memorial Sloan-Kettering Cancer Center (MSKCC) report in the February issue of Nature Genetics that inactivation of just one copy of a gene called PTEN and both copies of a gene called p27 leads to prostate cancer in mice 100 percent of the time. Mutations in the PTEN gene are frequently found in human prostate cancer. And, for the first time, scientists now have a mouse model for prostate cancer in which the tumors have the same features as prostate tumors in humans. According to the study's lead author, Pier Paolo Pandolfi, M.D., Ph.D., Head of the Molecular and Developmental Biology Laboratory at Memorial Sloan-Kettering, having this model will lead to better methods for testing potential new drugs to fight the disease.

Related Articles


These mutations provide insight into genetic variations that may lead to more severe forms of prostate cancer in humans. MSKCC researchers had previously found that loss of the p27 protein in men led to a higher rate of recurrence for prostate cancer and a poorer long-term survival. The new finding may allow doctors to eventually refine their diagnosis and treatment of tumor types in men.

However, further research is needed to determine if these gene mutations affect humans in the same way they affect mice. In addition, testing for these gene mutations is not readily available at this time. Prostate cancer experts stress the importance of clinical trials in future research.


Story Source:

The above story is based on materials provided by Memorial Sloan-Kettering Cancer Center. Note: Materials may be edited for content and length.


Cite This Page:

Memorial Sloan-Kettering Cancer Center. "Gene Mutations Found That Lead To Prostate Cancer In Mice New Mouse Model Developed To Study The Disease." ScienceDaily. ScienceDaily, 9 February 2001. <www.sciencedaily.com/releases/2001/02/010205073852.htm>.
Memorial Sloan-Kettering Cancer Center. (2001, February 9). Gene Mutations Found That Lead To Prostate Cancer In Mice New Mouse Model Developed To Study The Disease. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2001/02/010205073852.htm
Memorial Sloan-Kettering Cancer Center. "Gene Mutations Found That Lead To Prostate Cancer In Mice New Mouse Model Developed To Study The Disease." ScienceDaily. www.sciencedaily.com/releases/2001/02/010205073852.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins