Researchers at Memorial Sloan-Kettering Cancer Center (MSKCC) report in the February issue of Nature Genetics that inactivation of just one copy of a gene called PTEN and both copies of a gene called p27 leads to prostate cancer in mice 100 percent of the time. Mutations in the PTEN gene are frequently found in human prostate cancer. And, for the first time, scientists now have a mouse model for prostate cancer in which the tumors have the same features as prostate tumors in humans. According to the study's lead author, Pier Paolo Pandolfi, M.D., Ph.D., Head of the Molecular and Developmental Biology Laboratory at Memorial Sloan-Kettering, having this model will lead to better methods for testing potential new drugs to fight the disease.
The above story is based on materials provided by Memorial Sloan-Kettering Cancer Center. Note: Materials may be edited for content and length.
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