Featured Research

from universities, journals, and other organizations

Study Shows Reduction Of Inflammation Helps Heal Heart

Date:
March 1, 2001
Source:
Baylor College Of Medicine
Summary:
Reducing heart inflammation is showing promise as a treatment for chronic heart failure, according to a study published in the Feb. 27 issue of Circulation: Journal of the American Heart Association.

HOUSTON (Feb. 27, 2001) -- Reducing heart inflammation is showing promise as a treatment for chronic heart failure, according to a study published in the Feb. 27 issue of Circulation: Journal of the American Heart Association.

The study conducted by Baylor College of Medicine and the University of Pittsburgh Medical Center found that the drug etanercept, commonly used to reduce inflammation and prevent damage in the joints of patients with rheumatoid arthritis, also reduces inflammation in the heart. The inflammation produces a substance in the body called tumor necrosis factor that can damage heart tissue.

"Etanercept acts as a decoy to divert TNF away from injured heart cells," said Dr. Douglas Mann, professor of medicine and director of the Winters Center for Heart Failure Research at Baylor. "As a result, the heart is better able to heal."

Etanercept is designed to be used in conjunction with traditional therapies such as ACE inhibitors and vasodilators, which expand blood vessels, decrease resistance and allow blood to flow to the heart more easily. Patients administered the drug themselves by injection.

"In comparison with etanercept, traditional heart failure medications can be difficult to give, since they affect blood pressure and require the doctor to continually adjust the patient's dosage," Mann said. "Etanercept may give doctors another option to consider when developing their treatment plan."

In the study, etanercept improved quality of life in more than 60 percent of the 47 patients treated in the three-month study. The drug improved heart-pumping capacity in patients who received the highest dosage of the drug by an average of 20 percent and reduced the size of the heart by an average of 15 percent.

The study builds on earlier Baylor research on inflammation and the heart. Mann's laboratory discovered that the heart produces TNF when injured. Prior to this discovery, the immune system was thought to produce TNF in heart failure. This represented a change in the way in which scientists viewed the role of TNF in heart failure.

Baylor is continuing to investigate inflammation and the heart. Mann is the lead investigator in three multi-center clinical trials involving 1,800 patients. Study results are expected by the end of 2001.

"If the trials are positive, they could lead to a new and novel form of therapy for patients with chronic heart failure," Mann said.

Etanercept is manufactured under the tradename Enbrelฎ by Immunex Corporation of Seattle, Wash.


Story Source:

The above story is based on materials provided by Baylor College Of Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Baylor College Of Medicine. "Study Shows Reduction Of Inflammation Helps Heal Heart." ScienceDaily. ScienceDaily, 1 March 2001. <www.sciencedaily.com/releases/2001/03/010301072117.htm>.
Baylor College Of Medicine. (2001, March 1). Study Shows Reduction Of Inflammation Helps Heal Heart. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2001/03/010301072117.htm
Baylor College Of Medicine. "Study Shows Reduction Of Inflammation Helps Heal Heart." ScienceDaily. www.sciencedaily.com/releases/2001/03/010301072117.htm (accessed August 27, 2014).

Share This




More Health & Medicine News

Wednesday, August 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WHO Calls for Ban on E-Cigarette Sales to Minors

WHO Calls for Ban on E-Cigarette Sales to Minors

AFP (Aug. 26, 2014) — The World Health Organization called Tuesday on governments should ban the sale of e-cigarettes to minors, warning that they pose a "serious threat" to foetuses and young people. Duration: 01:44 Video provided by AFP
Powered by NewsLook.com
Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Newsy (Aug. 26, 2014) — A study published in the journal "Neurology" interviewed more than 19,000 people and found 15 percent suffer from being "sleep drunk." Video provided by Newsy
Powered by NewsLook.com
Does Medical Marijuana Reduce Painkiller Overdose Deaths?

Does Medical Marijuana Reduce Painkiller Overdose Deaths?

Newsy (Aug. 26, 2014) — A new study found fewer deaths from prescription drug overdoses in states that have legalized medical marijuana. But experts disagree on the results. Video provided by Newsy
Powered by NewsLook.com
Official: British Ebola Sufferer Receiving Experimental Drug

Official: British Ebola Sufferer Receiving Experimental Drug

AFP (Aug. 26, 2014) — A British nurse infected with Ebola while working in Sierra Leone is being given the same experimental drug used on two US missionaries who have recovered for the disease, doctors in London say. Duration: 00:44 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:  

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile iPhone Android Web
    Follow Facebook Twitter Google+
    Subscribe RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins