Featured Research

from universities, journals, and other organizations

New Discovery Offers Hope Of Better Treatments For Cocaine Addiction Relapse

Date:
May 15, 2001
Source:
Albert Einstein College Of Medicine
Summary:
Researchers at the Albert Einstein College of Medicine have identified a key mechanism involved in relapse to cocaine addiction. In determining the involvement of the neurotransmitter glutamate in relapse in the rat, the Einstein researchers also suggest a promising target for developing effective treatments for preventing relapses.

Researchers at the Albert Einstein College of Medicine have identified a key mechanism involved in relapse to cocaine addiction. In determining the involvement of the neurotransmitter glutamate in relapse in the rat, the Einstein researchers also suggest a promising target for developing effective treatments for preventing relapses. They report their findings in the May 11 issue of Science.

Related Articles


"We stimulated a region of the brain that contains the neurotransmitter glutamate and were able to cause relapse," explains Dr. Stanislav R. Vorel, first author of the study that he and his Einstein colleagues conducted in conjunction with Dr. Eliot Gardner of the National Institute on Drug Abuse, a unit of the U.S. National Institutes of Health.

The study explored the effects of electrical stimulation of the hippocampus region of the brain, which is one of the regions associated with memory.

"We found that electrical stimulation of the hippocampus, a memory area that may underlie the memory of drug effects, led to drug-seeking behavior," says Dr. Vorel, who is a graduate student at the Albert Einstein College of Medicine. Dr. Vorel previously received his M.D. degree in the Netherlands.

Further, the researchers were able to demonstrate that a glutamate blocker (kynurenic acid) blocks relapse, suggesting to them that glutamate blockers could be good ingredients for developing new addiction treatments.

"Previous drug development has focused on the neurotransmitter dopamine, which is connected to the 'liking' region of the brain, rather than the 'wanting' response we observed in the hippocampus," says Dr. Vorel. "Since 'wanting' a drug is more directly connected to relapse - which is the greatest hindrance to successful addiction treatment - we believe glutamate could prove a promising target for new drug developments designed to treat cocaine addiction."


Story Source:

The above story is based on materials provided by Albert Einstein College Of Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Albert Einstein College Of Medicine. "New Discovery Offers Hope Of Better Treatments For Cocaine Addiction Relapse." ScienceDaily. ScienceDaily, 15 May 2001. <www.sciencedaily.com/releases/2001/05/010511073954.htm>.
Albert Einstein College Of Medicine. (2001, May 15). New Discovery Offers Hope Of Better Treatments For Cocaine Addiction Relapse. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2001/05/010511073954.htm
Albert Einstein College Of Medicine. "New Discovery Offers Hope Of Better Treatments For Cocaine Addiction Relapse." ScienceDaily. www.sciencedaily.com/releases/2001/05/010511073954.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Mind & Brain News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Yoga Could Be As Beneficial For The Heart As Walking, Biking

Yoga Could Be As Beneficial For The Heart As Walking, Biking

Newsy (Dec. 17, 2014) Yoga can help your weight, blood pressure, cholesterol and heart just as much as biking and walking does, a new study suggests. Video provided by Newsy
Powered by NewsLook.com
1st Responders Trained for Autism Sensitivity

1st Responders Trained for Autism Sensitivity

AP (Dec. 16, 2014) More departments are ordering their first responders to sit in on training sessions that focus on how to more effectively interact with those with autism spectrum disorder (Dec. 16) Video provided by AP
Powered by NewsLook.com
Guys Are Idiots, According To Sarcastic Study

Guys Are Idiots, According To Sarcastic Study

Newsy (Dec. 12, 2014) A study out of Britain suggest men are more idiotic than women based on the rate of accidental deaths and other factors. Video provided by Newsy
Powered by NewsLook.com
Believing in Father Christmas Good for Children's Imaginations

Believing in Father Christmas Good for Children's Imaginations

AFP (Dec. 12, 2014) As the countdown to Christmas gets underway, so too does the Father Christmas conspiracy. But psychologists say that telling our children about Santa, flying reindeer and elves is good for their imaginations. Duration: 01:57 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins