Featured Research

from universities, journals, and other organizations

New Discovery Offers Hope Of Better Treatments For Cocaine Addiction Relapse

Date:
May 15, 2001
Source:
Albert Einstein College Of Medicine
Summary:
Researchers at the Albert Einstein College of Medicine have identified a key mechanism involved in relapse to cocaine addiction. In determining the involvement of the neurotransmitter glutamate in relapse in the rat, the Einstein researchers also suggest a promising target for developing effective treatments for preventing relapses.

Researchers at the Albert Einstein College of Medicine have identified a key mechanism involved in relapse to cocaine addiction. In determining the involvement of the neurotransmitter glutamate in relapse in the rat, the Einstein researchers also suggest a promising target for developing effective treatments for preventing relapses. They report their findings in the May 11 issue of Science.

Related Articles


"We stimulated a region of the brain that contains the neurotransmitter glutamate and were able to cause relapse," explains Dr. Stanislav R. Vorel, first author of the study that he and his Einstein colleagues conducted in conjunction with Dr. Eliot Gardner of the National Institute on Drug Abuse, a unit of the U.S. National Institutes of Health.

The study explored the effects of electrical stimulation of the hippocampus region of the brain, which is one of the regions associated with memory.

"We found that electrical stimulation of the hippocampus, a memory area that may underlie the memory of drug effects, led to drug-seeking behavior," says Dr. Vorel, who is a graduate student at the Albert Einstein College of Medicine. Dr. Vorel previously received his M.D. degree in the Netherlands.

Further, the researchers were able to demonstrate that a glutamate blocker (kynurenic acid) blocks relapse, suggesting to them that glutamate blockers could be good ingredients for developing new addiction treatments.

"Previous drug development has focused on the neurotransmitter dopamine, which is connected to the 'liking' region of the brain, rather than the 'wanting' response we observed in the hippocampus," says Dr. Vorel. "Since 'wanting' a drug is more directly connected to relapse - which is the greatest hindrance to successful addiction treatment - we believe glutamate could prove a promising target for new drug developments designed to treat cocaine addiction."


Story Source:

The above story is based on materials provided by Albert Einstein College Of Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Albert Einstein College Of Medicine. "New Discovery Offers Hope Of Better Treatments For Cocaine Addiction Relapse." ScienceDaily. ScienceDaily, 15 May 2001. <www.sciencedaily.com/releases/2001/05/010511073954.htm>.
Albert Einstein College Of Medicine. (2001, May 15). New Discovery Offers Hope Of Better Treatments For Cocaine Addiction Relapse. ScienceDaily. Retrieved February 28, 2015 from www.sciencedaily.com/releases/2001/05/010511073954.htm
Albert Einstein College Of Medicine. "New Discovery Offers Hope Of Better Treatments For Cocaine Addiction Relapse." ScienceDaily. www.sciencedaily.com/releases/2001/05/010511073954.htm (accessed February 28, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Saturday, February 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Foods to Battle Stress

The Best Foods to Battle Stress

Buzz60 (Feb. 26, 2015) If you&apos;re dealing with anxiety, there are a few foods that can help. Krystin Goodwin (@krystingoodwin) has the best foods to tame stress. Video provided by Buzz60
Powered by NewsLook.com
Sleeping Too Much Or Too Little Might Increase Stroke Risk

Sleeping Too Much Or Too Little Might Increase Stroke Risk

Newsy (Feb. 26, 2015) People who sleep more than eight hours per night are 45 percent more likely to have a stroke, according to a University of Cambridge study. Video provided by Newsy
Powered by NewsLook.com
Mayor Says District of Columbia to Go Ahead With Pot Legalization

Mayor Says District of Columbia to Go Ahead With Pot Legalization

Reuters - News Video Online (Feb. 25, 2015) Washington&apos;s mayor says the District of Columbia will move forward with marijuana legalization, despite pushback from Congress. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Marijuana Nowhere Near As Deadly As Alcohol: Study

Marijuana Nowhere Near As Deadly As Alcohol: Study

Newsy (Feb. 25, 2015) A new study says marijuana is about 114 times less deadly than alcohol. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins