Featured Research

from universities, journals, and other organizations

Liver Regrowth Depends On Prostaglandins

Date:
July 10, 2001
Source:
Washington University School Of Medicine
Summary:
Small fatty molecules called prostaglandins promote liver regrowth after injury, according to a study by researchers at Washington University School of Medicine in St. Louis.

St. Louis, July 10, 2001 — Small fatty molecules called prostaglandins promote liver regrowth after injury, according to a study by researchers at Washington University School of Medicine in St. Louis. "When we blocked prostaglandin synthesis, we found that the liver’s regenerative response was significantly impaired in a mouse model system," says David A. Rudnick, M.D., Ph.D., the study’s first author and an instructor in pediatrics. "This finding brings scientists one step closer to understanding liver disease and developing potential treatments."

Related Articles


Prostaglandins help regulate blood pressure, muscle contraction and blood clotting, but their role in liver regeneration was not well characterized. The research is reported in the July 10 issue of Early Edition of the Proceedings of the National Academy of Sciences.

The work was performed in the laboratory of Louis J. Muglia, M.D., Ph.D., assistant professor of pediatrics, of obstetrics and gynecology and of molecular biology and pharmacology, and in collaboration with David H. Perlmutter, M.D., who is now at the University of Pittsburgh School of Medicine. Unlike most organs, the liver can grow back after infection, trauma, chemical damage or other assaults. In the mouse study, Rudnick and colleagues removed part of the liver and watched it grow back over hours and days.

Before the surgery, they treated some of the mice with drugs called COX inhibitors. These compounds, which also are used to treat inflammatory disorders such as arthritis, inhibit one or both of two enzymes that make prostaglandins: cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). Control mice had the surgery but did not receive the drugs.

Forty-two hours after surgery, the livers of the control mice exhibited a robust and appropriate regenerative response in the remaining tissue, while the livers of the animals treated with an inhibitor of both COX enzymes or with a COX-2 inhibitor did not. An additional experiment on genetically altered mice showed that COX-2 plays an important role in liver regeneration with or without COX-1. "These results show that prostaglandins are required for efficient liver regeneration in this model system and implicate a role for them in the regenerative response seen in liver disease," Rudnick says.

He notes that the ancient Greeks described liver regeneration. Prometheus, who stole fire from Zeus and gave it to humans, was punished by being chained to a rock. Every day, an eagle tore out his liver, which grew back completely every night. "That story has many things in common with our mouse model," Rudnick says. "The liver grows back until it is 100 percent of its former size, and then the regenerative response stops. If it is injured again, it can grow back again, and it can do this over and over."

The researchers now are determining how prostaglandins affect gene expression during liver regeneration.

Reference: Rudnick DA, Perlmutter DH, Muglia LJ. Prostaglandins are required for CREB activation and cellular proliferation during liver regeneration. Early Edition of the Proceedings of the National Academy of Sciences, 2(28), Article # 2179, July 10, 2001.

Funding from the National Institutes of Health, American Digestive Health Foundation, American Gastroenterological Association and Burroughs Wellcome Fund supported this research.

The full-time and volunteer faculty of Washington University School of Medicine are the physicians and surgeons of Barnes-Jewish and St. Louis Children's hospitals. The School of Medicine is one of the leading medical research, teaching and patient-care institutions in the nation. Through its affiliations with Barnes-Jewish and St. Louis Children's hospitals, the School of Medicine is linked to BJC HealthCare.


Story Source:

The above story is based on materials provided by Washington University School Of Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Washington University School Of Medicine. "Liver Regrowth Depends On Prostaglandins." ScienceDaily. ScienceDaily, 10 July 2001. <www.sciencedaily.com/releases/2001/07/010710074124.htm>.
Washington University School Of Medicine. (2001, July 10). Liver Regrowth Depends On Prostaglandins. ScienceDaily. Retrieved April 1, 2015 from www.sciencedaily.com/releases/2001/07/010710074124.htm
Washington University School Of Medicine. "Liver Regrowth Depends On Prostaglandins." ScienceDaily. www.sciencedaily.com/releases/2001/07/010710074124.htm (accessed April 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, April 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

AFP (Apr. 1, 2015) The governments of Liberia and Sierra Leone have been busy fighting the menace created by the deadly Ebola virus, but illicit drug lords have taken advantage of the situation to advance the drug trade. Duration: 01:12 Video provided by AFP
Powered by NewsLook.com
Stigma Stalks India's Leprosy Sufferers as Disease Returns

Stigma Stalks India's Leprosy Sufferers as Disease Returns

AFP (Apr. 1, 2015) The Indian government declared victory over leprosy in 2005, but the disease is making a comeback in some parts of the country, with more than a hundred thousand lepers still living in colonies, shunned from society. Duration: 02:41 Video provided by AFP
Powered by NewsLook.com
7-Year-Old Girl Gets 3-D Printed 'robohand'

7-Year-Old Girl Gets 3-D Printed 'robohand'

AP (Mar. 31, 2015) Although she never had much interest in prosthetic limbs before, Faith Lennox couldn&apos;t wait to slip on her new robohand. The 7-year-old, who lost part of her left arm when she was a baby, grabbed it as soon as it came off a 3-D printer. (March 31) Video provided by AP
Powered by NewsLook.com
Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins