Featured Research

from universities, journals, and other organizations

NYU Researchers Successfully Immunize Mice Against Alzheimer's

Date:
August 7, 2001
Source:
New York University Medical Center And School Of Medicine
Summary:
NYU School of Medicine researchers have prevented the development of Alzheimer's disease in mice genetically engineered with the human gene for the disease using a new vaccine. The researchers are optimistic that this new vaccine is safer than one already being tested in early human clinical trials.

NEW YORK, August 2 - NYU School of Medicine researchers have prevented the development of Alzheimer's disease in mice genetically engineered with the human gene for the disease using a new vaccine. The researchers are optimistic that this new vaccine is safer than one already being tested in early human clinical trials.

In a new study, the researchers report that the new vaccine, modeled on a fragment of a protein called amyloid, which is most frequently implicated in causing Alzheimer's, reduced the amount of amyloid plaque in the brains of mice by 89 percent. And, at the same time, the vaccine reduced the amount of soluble amyloid beta in the brain by 57 percent.

"Our study clearly shows that the vaccination approach is a powerful one that shows great promise for Alzheimer's disease," says Thomas Wisniewski, M.D., Associate Professor of Neurology, Pathology, and Psychiatry at NYU School of Medicine, one of the study's authors. "And significantly, our approach appears to be non-toxic," he says.

"We believe that our peptide vaccine isn't toxic to nerve cells because it doesn't aggregate into clumps; it remains in solution," says Blas Frangione, M.D., Ph.D., Professor of Pathology at NYU School of Medicine, an author of the study and a pioneering researcher who played an important role in elucidating the role of amyloid proteins in Alzheimer's disease and other forms of dementia.

The NYU researchers believe that early clinical trials of the new vaccine could begin within one year. The new study is published in the August 2 issue of the American Journal of Pathology. The lead author of the study is Einar Sigurdsson, Ph.D., Research Assistant Professor at NYU School of Medicine.

The first report of a vaccine against Alzheimer's in genetically engineered mice emerged less than two years ago using a vaccine made of a fragment of amyloid- precursor protein. This vaccine is now being tested in early clinical trials. But the NYU researchers are concerned that a vaccine based on this fragment could be toxic to nerve cells in the brain and may by itself trigger the formation of fibrils of plaque-forming amyloid. The NYU group set out to design a safer vaccine.

Alzheimer's is characterized by the destruction of nerve cells, especially in the areas of the brain vital to memory and learning. Round plaques composed of the amyloid protein are one of the hallmarks of the disease, and many researchers believe amyloid causes the death of nerve cells.

In previous studies, Dr. Frangione's group was able to block the formation of amyloid plaque in the brains of rats by creating a short peptide (a fragment of a protein) called a beta-sheet breaker. This peptide prevented the formation of a toxic, insoluble, helical form of amyloid that aggregates into so-called beta sheets and is deposited in plaques in the brain.

In the new study, Dr. Sigurdsson, along with Drs. Wisniewski and Frangione, used the same principle to create a vaccine based on a modified, non-toxic peptide. They injected the new vaccine into 11-month-old mice genetically engineered with a human gene for Alzheimer's disease. At that age, the mice had already formed toxic amyloid plaques in the brain.

Seven months later, the researchers examined the brains of the mice. They found that the amount of the bad form of amyloid was reduced by 89 percent in the cortex, the seat of higher thought in the brain, and by 81 percent in the hippocampus, the brain's memory center, compared to the brains of a group of genetically engineered animals that didn't get the vaccine. Moreover, the vaccinated animals had 57 percent less soluble amyloid.


Story Source:

The above story is based on materials provided by New York University Medical Center And School Of Medicine. Note: Materials may be edited for content and length.


Cite This Page:

New York University Medical Center And School Of Medicine. "NYU Researchers Successfully Immunize Mice Against Alzheimer's." ScienceDaily. ScienceDaily, 7 August 2001. <www.sciencedaily.com/releases/2001/08/010806074736.htm>.
New York University Medical Center And School Of Medicine. (2001, August 7). NYU Researchers Successfully Immunize Mice Against Alzheimer's. ScienceDaily. Retrieved August 29, 2014 from www.sciencedaily.com/releases/2001/08/010806074736.htm
New York University Medical Center And School Of Medicine. "NYU Researchers Successfully Immunize Mice Against Alzheimer's." ScienceDaily. www.sciencedaily.com/releases/2001/08/010806074736.htm (accessed August 29, 2014).

Share This




More Mind & Brain News

Friday, August 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Treadmill 'trips' May Reduce Falls for Elderly

Treadmill 'trips' May Reduce Falls for Elderly

AP (Aug. 28, 2014) Scientists are tripping the elderly on purpose in a Chicago lab in an effort to better prevent seniors from falling and injuring themselves in real life. (Aug.28) Video provided by AP
Powered by NewsLook.com
Alice in Wonderland Syndrome

Alice in Wonderland Syndrome

Ivanhoe (Aug. 27, 2014) It’s an unusual condition with a colorful name. Kids with “Alice in Wonderland” syndrome see sudden distortions in objects they’re looking at or their own bodies appear to change size, a lot like the main character in the Lewis Carroll story. Video provided by Ivanhoe
Powered by NewsLook.com
Stopping Schizophrenia Before Birth

Stopping Schizophrenia Before Birth

Ivanhoe (Aug. 27, 2014) Scientists have long called choline a “brain booster” essential for human development. Not only does it aid in memory and learning, researchers now believe choline could help prevent mental illness. Video provided by Ivanhoe
Powered by NewsLook.com
Personalized Brain Vaccine for Glioblastoma

Personalized Brain Vaccine for Glioblastoma

Ivanhoe (Aug. 27, 2014) Glioblastoma is the most common and aggressive brain cancer in humans. Now a new treatment using the patient’s own tumor could help slow down its progression and help patients live longer. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins