Featured Research

from universities, journals, and other organizations

Scientists Find New Approach To Developing Medications To Prevent Relapse To Cocaine Use

Date:
October 3, 2001
Source:
NIH/National Institute On Drug Abuse
Summary:
Research teams from the Drug Abuse Program of the VU Medical Center in the Netherlands and the intramural laboratories of the National Institute on Drug Abuse (NIDA) have identified a process in the brain that may lead to a new generation of medications to prevent relapse to cocaine use.

Research teams from the Drug Abuse Program of the VU Medical Center in the Netherlands and the intramural laboratories of the National Institute on Drug Abuse (NIDA) have identified a process in the brain that may lead to a new generation of medications to prevent relapse to cocaine use.

In studies using rats, the scientists, led by Dr. Taco J. De Vries of VU Medical Center and Dr. Yavin Shaham of NIDA, found that the same system–the cannabinoid system–that governs the pharmacological actions of marijuana in the brain also plays an important role in the neuronal processes underlying relapse to cocaine use.

By blocking cannabinoid receptor activity with chemical antagonists, the investigators prevented relapse to cocaine use induced by exposure to cocaine-associated cues or by cocaine itself.

NIDA Director Dr. Alan I. Leshner says, “This finding could open up a new avenue for the development of drugs to prevent relapse to cocaine use induced by environmental cues.

Treatment of cocaine addiction has always been hampered by high rates of relapse, even after prolonged drug abstinence, and this research could be the first step in the development of a new medicinal approach to make it easier for a recovering addict to remain drug-free.”

Dr. De Vries of the Dutch research team says that findings from this and other experiments indicate that the CB1 cannabinoid receptor is a promising target for a pharmacological intervention to prevent relapse to cocaine seeking.

In this study, according to Dr. De Vries, the CB1 receptor antagonist, SR141716A, administered to the rats reduced relapse to cocaine-seeking behavior in two of the three most common conditions associated with relapse: exposure to stimuli or environmental cues previously associated with cocaine use and exposure to cocaine itself. It had no effect on relapse triggered by stress.

The study is published in the October 1 issue of Nature-Medicine.

###

The National Institute on Drug Abuse is a component of the National Institutes of Health, U.S. Department of Health and Human Services. NIDA supports more than 85 percent of the world's research on the health aspects of drug abuse and addiction.

The Institute carries out a large variety of programs to ensure the rapid dissemination of research information and its implementation in policy and practice. Fact sheets on the health effects of drugs of abuse and other topics can be ordered free of charge in English and Spanish through NIDA Infofax at 1-888-NIH-NIDA (644-6432) or 1-888-TTY-NIDA (889-6432) for the deaf. These fact sheets and further information on NIDA research and other activities can be found on the NIDA home page at http://www.drugabuse.gov


Story Source:

The above story is based on materials provided by NIH/National Institute On Drug Abuse. Note: Materials may be edited for content and length.


Cite This Page:

NIH/National Institute On Drug Abuse. "Scientists Find New Approach To Developing Medications To Prevent Relapse To Cocaine Use." ScienceDaily. ScienceDaily, 3 October 2001. <www.sciencedaily.com/releases/2001/10/011003064621.htm>.
NIH/National Institute On Drug Abuse. (2001, October 3). Scientists Find New Approach To Developing Medications To Prevent Relapse To Cocaine Use. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2001/10/011003064621.htm
NIH/National Institute On Drug Abuse. "Scientists Find New Approach To Developing Medications To Prevent Relapse To Cocaine Use." ScienceDaily. www.sciencedaily.com/releases/2001/10/011003064621.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins