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Therapeutic Drug Blocks Nicotine's Effects On Brain Chemistry; Study In Rats May Lead To Treatment For Nicotine Addiction In Humans

Date:
November 9, 2001
Source:
Brookhaven National Laboratory
Summary:
Nicotine is widely believed to trigger dependence by elevating certain brain chemicals associated with pleasure and reward. Now, a study in rats at the U.S. Department of Energy's Brookhaven National Laboratory shows that topiramate -- a new anticonvulsant drug sold under the brand name Topomax®, currently used for the treatment of epilepsy -- can block some of the nicotine-triggered changes in brain chemistry, and may have potential for the treatment of nicotine addiction in humans.

UPTON, NY -- Nicotine is widely believed to trigger dependence by elevating certain brain chemicals associated with pleasure and reward. Now, a study in rats at the U.S. Department of Energy's Brookhaven National Laboratory shows that topiramate -- a new anticonvulsant drug sold under the brand name Topomax®, currently used for the treatment of epilepsy -- can block some of the nicotine-triggered changes in brain chemistry, and may have potential for the treatment of nicotine addiction in humans.


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The above story is based on materials provided by Brookhaven National Laboratory. Note: Materials may be edited for content and length.


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Brookhaven National Laboratory. "Therapeutic Drug Blocks Nicotine's Effects On Brain Chemistry; Study In Rats May Lead To Treatment For Nicotine Addiction In Humans." ScienceDaily. ScienceDaily, 9 November 2001. <www.sciencedaily.com/releases/2001/11/011109075124.htm>.
Brookhaven National Laboratory. (2001, November 9). Therapeutic Drug Blocks Nicotine's Effects On Brain Chemistry; Study In Rats May Lead To Treatment For Nicotine Addiction In Humans. ScienceDaily. Retrieved April 25, 2014 from www.sciencedaily.com/releases/2001/11/011109075124.htm
Brookhaven National Laboratory. "Therapeutic Drug Blocks Nicotine's Effects On Brain Chemistry; Study In Rats May Lead To Treatment For Nicotine Addiction In Humans." ScienceDaily. www.sciencedaily.com/releases/2001/11/011109075124.htm (accessed April 25, 2014).

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