Featured Research

from universities, journals, and other organizations

Low Levels Of A Good Cholesterol Enzyme Bad For Artery Disease

Date:
December 18, 2001
Source:
American Heart Association
Summary:
An enzyme that breaks up lipids in high-density lipoprotein (HDL – the “good” cholesterol), was associated with severity of coronary artery disease (CAD), according to a study in Circulation: Journal of the American Heart Association.

DALLAS, Dec. 18 – An enzyme that breaks up lipids in high-density lipoprotein (HDL – the “good” cholesterol), was associated with severity of coronary artery disease (CAD), according to a study in today’s Circulation: Journal of the American Heart Association. People with the lowest activity levels of an enzyme called hepatic lipase (HL) had 50 percent more severe CAD than those with the highest levels, says lead author Klaus A. Dugi, M.D., a researcher in the department of internal medicine at the University of Heidelberg, in Germany.

“Low hepatic lipase activity may help identify individuals who are at risk for coronary artery disease despite normal or high levels of HDL. In the future, drugs that affect HL activity may help prevent and treat CAD,” he says.

HL activity in the blood was measured in 200 men undergoing elective coronary angiography. HL activity was determined in 23 patients with normal angiograms for comparison. Participants were given a CAD extent score, indicating the level of disease in their coronary arteries. Hepatic lipase breaks down triglycerides and phospholipids (fats) in circulating lipoproteins, but its importance to the development of cardiovascular disease is unclear.

The researchers found a significant inverse relationship between HL activity and CAD extent. HL activity was lower in 173 patients with CAD than in 40 controls with normal angiograms (286 nmol per mL, per minute vs. 338 nmol per mL, per min.). Further, when results were expressed in quartiles, HL activity in the lower quartiles was consistently associated with greater CAD extent. Individuals who had the highest hepatic lipase activity (top quartile), which was greater than 358 nmol, had an average extent score of 32.6. Those with the lowest HL activity – less than 213 nmol – had the highest CAD extent at 45.1.

Dugi plans further research to find out if low HL activity is linked to higher risk of heart attack.

Co-authors include: Karin Brandauer; Nikolaus Schmidt; Barbara Nau; Jochen G. Schneider, M.D.; Stefani Mentz, M.D.; Tanja Keiper; Jeurgen R. Schaefer, M.D.; Christoph Meissner, M.D.; Horst Kather, M.D.; Malte L. Bahner, M.D.; Walter Fiehn, M.D.; and Joerg Kreuzer, M.D.

Editor’s Note: The American Heart Association endorses the National Cholesterol Education Program (NCEP) guidelines for detection of high cholesterol. For more information on cholesterol guidelines, visit: http://www.americanheart.org/presenter.jhtml?identifier=4500.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Cite This Page:

American Heart Association. "Low Levels Of A Good Cholesterol Enzyme Bad For Artery Disease." ScienceDaily. ScienceDaily, 18 December 2001. <www.sciencedaily.com/releases/2001/12/011218073935.htm>.
American Heart Association. (2001, December 18). Low Levels Of A Good Cholesterol Enzyme Bad For Artery Disease. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2001/12/011218073935.htm
American Heart Association. "Low Levels Of A Good Cholesterol Enzyme Bad For Artery Disease." ScienceDaily. www.sciencedaily.com/releases/2001/12/011218073935.htm (accessed August 27, 2014).

Share This




More Health & Medicine News

Wednesday, August 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WHO Calls for Ban on E-Cigarette Sales to Minors

WHO Calls for Ban on E-Cigarette Sales to Minors

AFP (Aug. 26, 2014) — The World Health Organization called Tuesday on governments should ban the sale of e-cigarettes to minors, warning that they pose a "serious threat" to foetuses and young people. Duration: 01:44 Video provided by AFP
Powered by NewsLook.com
Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Newsy (Aug. 26, 2014) — A study published in the journal "Neurology" interviewed more than 19,000 people and found 15 percent suffer from being "sleep drunk." Video provided by Newsy
Powered by NewsLook.com
Does Medical Marijuana Reduce Painkiller Overdose Deaths?

Does Medical Marijuana Reduce Painkiller Overdose Deaths?

Newsy (Aug. 26, 2014) — A new study found fewer deaths from prescription drug overdoses in states that have legalized medical marijuana. But experts disagree on the results. Video provided by Newsy
Powered by NewsLook.com
Official: British Ebola Sufferer Receiving Experimental Drug

Official: British Ebola Sufferer Receiving Experimental Drug

AFP (Aug. 26, 2014) — A British nurse infected with Ebola while working in Sierra Leone is being given the same experimental drug used on two US missionaries who have recovered for the disease, doctors in London say. Duration: 00:44 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:  

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile iPhone Android Web
    Follow Facebook Twitter Google+
    Subscribe RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins