Featured Research

from universities, journals, and other organizations

Gene Linked To Accelerated Brain Aging In Healthy Adults

Date:
February 27, 2002
Source:
Duke University Medical Center
Summary:
By studying a chemical marker in the brain that reflects the health of brain tissue, researchers at Duke University Medical Center have found new clues about why some people experience more rapid age-related brain changes than others.

ORLANDO, Fla. – By studying a chemical marker in the brain that reflects the health of brain tissue, researchers at Duke University Medical Center have found new clues about why some people experience more rapid age-related brain changes than others.

The researchers have found an association between nerve cell changes associated with aging and the presence of a variation of the apolipoprotein gene known as apolipoprotein E4 (APOE4). This form is carried by approximately 25 percent of the population and has been linked to increased risk of Alzheimer's disease, cardiovascular disease and memory loss after head injury or bypass surgery.

Although the signs of age-related memory loss are widely recognized, researchers are still unsure why some elderly adults retain strong mental capacity well into their 90s while others fall into progressive decline or dementia.

"The frontal lobe is the site where the earliest and most consistent effects of aging occur in the brain," said P. Murali Doraiswamy, M.D., a psychiatrist at Duke and lead researcher on the study. "Virtually every mental symptom of normal aging results from decline in frontal lobe functions. When we examined this vital area of the brain by following a particular genetic marker, we found a single gene variation that can result in significant nerve cell changes associated with aging. Of the people we studied, those who carried the APOE4 gene experienced a more rapid loss of nerve cell functioning."

In other words, their brains showed signs of aging faster than those without the gene.

The research team was scheduled to present their findings today (Feb. 25, 2002) at the 15th annual meeting of the American Association for Geriatric Psychiatry in Orlando, Fla.

Doraiswamy's team decided to measure levels of N-acetylspartate (NAA), a brain chemical known to be closely associated to nerve cells, and hence to mental functions. This chemical is primarily found inside nerve cells within the brain. The presence of NAA signals the health, or lack thereof, of a nerve cell.

"It is generally accepted that dying nerve cells have lower levels of NAA but little is known about the chemical's role in a particular disease," said Doraiswamy. "It's what we call a surrogate marker."

By using magnetic resonance spectroscopy (MRS), researchers were able to detect nerve cell changes associated with aging in people with dissimilar genetic makeup. MRS uses magnetic fields and radio waves to provide researchers a way to detect subtle changes in specific chemicals inside nerve cells to determine the cells' health, damage and loss of function. Using MRS in a baseline study, the researchers compared the level of NAA in the brains of 165 healthy study participants who ranged in age from 55 to 85. Of these, 84 participants were postmenopausal women and 81 were men.

All participants had mental capacities representative of normal older people. The subjects were divided into two groups based on whether they were carriers of the APOE4 gene or not. After undergoing MRS both groups were administered a battery of memory tests to obtain their NAA and cognitive levels. After two years, a subset of the participants was studied again with memory tests.

The researchers found that those with lower NAA levels at the beginning of the study had greater loss of short-term memory and naming abilities after two years. To determine loss of NAA across an age span (in this case as healthy adults aged from their 50s to their 80s) the researchers simply compared the age ranges within the APOE4 group and the non-APOE4 group.

"We found that NAA levels declined mildly with increasing age for all participants in the study," said Doraiswamy. "But when the sample was broken down by genetic makeup, the average loss of NAA across the age span was nearly three-fold higher in people with the APOE4 gene than in those who were not carriers of this gene."

Thus, the researchers concluded that the brains of those who carry the APOE4 gene show greater deterioration than those who do not. "This is an important finding in the study of aging. I believe it will lead to a greater understanding of age-related memory loss and hopefully, one day, to ways of keeping our brains sharper, longer," noted Doraiswamy.

This study was funded by the American Federation for Aging Research and through the Paul Beeson Physician Scholar Award (P. Doraiswamy).

Collaborators on the study included Cecil Charles Ph.D.; Dan Barboriak, M.D.; and Gene Chen.


Story Source:

The above story is based on materials provided by Duke University Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Duke University Medical Center. "Gene Linked To Accelerated Brain Aging In Healthy Adults." ScienceDaily. ScienceDaily, 27 February 2002. <www.sciencedaily.com/releases/2002/02/020226074159.htm>.
Duke University Medical Center. (2002, February 27). Gene Linked To Accelerated Brain Aging In Healthy Adults. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2002/02/020226074159.htm
Duke University Medical Center. "Gene Linked To Accelerated Brain Aging In Healthy Adults." ScienceDaily. www.sciencedaily.com/releases/2002/02/020226074159.htm (accessed September 17, 2014).

Share This



More Mind & Brain News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Corporal Punishment on Decline, Debate Renews

Corporal Punishment on Decline, Debate Renews

AP (Sep. 16, 2014) Corporal punishment in the United States is on the decline, but there is renewed debate over its use after Minnesota Vikings running back Adrian Peterson was charged with child abuse. (Sept. 16) Video provided by AP
Powered by NewsLook.com
FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com
Shocker: Journalists Are Utterly Addicted To Coffee

Shocker: Journalists Are Utterly Addicted To Coffee

Newsy (Sep. 13, 2014) A U.K. survey found that journalists consumed the most amount of coffee, but that's only the tip of the coffee-related statistics iceberg. Video provided by Newsy
Powered by NewsLook.com
'Magic Mushrooms' Could Help Smokers Quit

'Magic Mushrooms' Could Help Smokers Quit

Newsy (Sep. 11, 2014) In a small study, researchers found that the majority of long-time smokers quit after taking psilocybin pills and undergoing therapy sessions. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins