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Scientists Close In On Trigger Of Insulin Resistance; Extra Sugar Can Cause Insulin Resistance In Cells

Date:
April 16, 2002
Source:
Johns Hopkins Medical Institutions
Summary:
In experiments with fat cells, Johns Hopkins scientists have discovered direct evidence that a build-up of sugar on proteins triggers insulin resistance, a key feature of most cases of diabetes.

In experiments with fat cells, Johns Hopkins scientists have discovered direct evidence that a build-up of sugar on proteins triggers insulin resistance, a key feature of most cases of diabetes. The results underscore the importance of glycosylation – attachment of a sugar to a protein -- as a way cells control proteins' activities, the scientists report in the April 16 issue of the Proceedings of the National Academy of Sciences. The scientists found that at least two proteins involved in passing along insulin's message were unlikely to work properly when coated in extra sugar.


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The above story is based on materials provided by Johns Hopkins Medical Institutions. Note: Materials may be edited for content and length.


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Johns Hopkins Medical Institutions. "Scientists Close In On Trigger Of Insulin Resistance; Extra Sugar Can Cause Insulin Resistance In Cells." ScienceDaily. ScienceDaily, 16 April 2002. <www.sciencedaily.com/releases/2002/04/020416073449.htm>.
Johns Hopkins Medical Institutions. (2002, April 16). Scientists Close In On Trigger Of Insulin Resistance; Extra Sugar Can Cause Insulin Resistance In Cells. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2002/04/020416073449.htm
Johns Hopkins Medical Institutions. "Scientists Close In On Trigger Of Insulin Resistance; Extra Sugar Can Cause Insulin Resistance In Cells." ScienceDaily. www.sciencedaily.com/releases/2002/04/020416073449.htm (accessed April 23, 2014).

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