Featured Research

from universities, journals, and other organizations

Mayo Clinic Study Links Gene To Heart Disease Marker; Gene Variations May Be Early Risk Factor For Inflammatory Diseases

Date:
May 20, 2002
Source:
Mayo Clinic
Summary:
Common variations in a single gene are associated with increased blood levels of C-reactive Protein (CRP), a biomarker that has recently become an important risk factor for cardiovascular disease, according to a Mayo Clinic study published in the May 17 issue of the journal Cytokine. The researchers’ findings are the first to demonstrate a strong connection between common variations in IL-1 genes and the production of CRP and other inflammatory proteins by the liver.

ROCHESTER, MINN. -- Common variations in a single gene are associated with increased blood levels of C-reactive Protein (CRP), a biomarker that has recently become an important risk factor for cardiovascular disease, according to a Mayo Clinic study published in the May 17 issue of the journal Cytokine.

Related Articles


The researchers’ findings are the first to demonstrate a strong connection between common variations in IL-1 genes and the production of CRP and other inflammatory proteins by the liver.

Numerous studies have identified inflammation as a major component of the atherosclerosis disease process, the accumulation of fatty plaques in arteries that can lead to heart attack or stroke. CRP, a protein marker of inflammation, has recently been recognized as a significant factor in understanding cardiovascular disease. IL-1, a primary regulator of inflammation, wound healing and bone and connective tissue responses following injury or the onset of disease, starts the chain reaction of inflammatory proteins that leads to production of CRP.

"By understanding the genetic underpinnings of cardiovascular disease, physicians may in the future be able to take a more complete approach to managing patient care," says Peter Berger, M.D., Mayo Clinic cardiologist and the lead author on the paper. "Factors that influence genetic predisposition to disease may enable doctors to identify patients who are most at risk at an earlier age. Furthermore, the growing body of knowledge about markers, such as CRP, may help physicians in monitoring the onset and progression of disease as well as the effectiveness of therapeutic interventions."

To evaluate genetic influence on the inflammatory response, researchers identified the presence of four common polymorphisms in IL-1 genes in 454 patients undergoing coronary angiography. Those variations were analyzed to determine their influence on plasma CRP and fibrinogen levels. CRP levels remained significantly associated with IL-1 polymorphisms after adjustment for smoking, gender and age. Levels of fibrinogen, another marker, had similar associations with the IL-1 genotypes.

The study was done in cooperation with researchers from Interleukin Genetics and University of Sheffield (England) and was funded by Interleukin Genetics.


Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials may be edited for content and length.


Cite This Page:

Mayo Clinic. "Mayo Clinic Study Links Gene To Heart Disease Marker; Gene Variations May Be Early Risk Factor For Inflammatory Diseases." ScienceDaily. ScienceDaily, 20 May 2002. <www.sciencedaily.com/releases/2002/05/020517075011.htm>.
Mayo Clinic. (2002, May 20). Mayo Clinic Study Links Gene To Heart Disease Marker; Gene Variations May Be Early Risk Factor For Inflammatory Diseases. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2002/05/020517075011.htm
Mayo Clinic. "Mayo Clinic Study Links Gene To Heart Disease Marker; Gene Variations May Be Early Risk Factor For Inflammatory Diseases." ScienceDaily. www.sciencedaily.com/releases/2002/05/020517075011.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Why Your Boss Should Let You Sleep In

Why Your Boss Should Let You Sleep In

Newsy (Dec. 17, 2014) According to research out of the University of Pennsylvania, waking up for work is the biggest factor that causes Americans to lose sleep. Video provided by Newsy
Powered by NewsLook.com
Flu Outbreak Closing Schools in Ohio

Flu Outbreak Closing Schools in Ohio

AP (Dec. 17, 2014) A wave of flu illnesses has forced some Ohio schools to shut down over the past week. State officials confirmed one pediatric flu-related death, a 15-year-old girl in southern Ohio. (Dec. 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins