Featured Research

from universities, journals, and other organizations

Aspirin Within Two Days Of Ischemic Stroke Reduces Deaths

Date:
July 10, 2002
Source:
American Heart Association
Summary:
Giving patients aspirin within 48 hours of the onset of an acute ischemic stroke can reduce death and severity of stroke, according to a joint scientific statement from the American Stroke Association and the American Academy of Neurology.

DALLAS, July 9 – Giving patients aspirin within 48 hours of the onset of an acute ischemic stroke can reduce death and severity of stroke, according to a joint scientific statement from the American Stroke Association and the American Academy of Neurology.

An ischemic stroke is caused by a blood clot and is the most common type of stroke.

The statement, published in the July issues of Stroke: Journal of the American Heart Association, and Neurology, the scientific journal of the American Academy of Neurology, aims to define the roles of drugs such as aspirin – which is in a class of drugs called antiplatelet agents that prevent blood clot formation – and drugs such as heparin, a type of anticoagulant that slows blood clotting.

The authors conducted a systematic review of the literature, looking primarily for well-designed, large prospective studies in which patients were randomly selected and blinded (they didn't know what type of therapy they were receiving).

They found evidence from the published trials that giving 160 – 325 mg of aspirin within 48 hours of stroke onset offers a "small but statistically significant" decrease in death rates and disability from stroke. Recommendations on the use of other types of antiplatelet agents, such as clopidogrel and ticlopidine within the first 48 hours of onset could not be made due to insufficient data.

Conversely, anticoagulants have not been shown to reduce death or disability when used within 48 hours.

"There is some evidence that a fixed dose of heparin given subcutaneously might be helpful for preventing recurrent stroke, but the benefit is balanced against the complication of increased hemorrhage. With the net effect, there is no benefit to that treatment. Therefore, we are not recommending that one use a fixed dose of heparin given subcutaneously to prevent stroke recurrence," says neurologist Bruce Coull, M.D., chair of the Joint Stroke Guideline Development Committee.

In a second major recommendation, the authors note that subcutaneous heparin should be considered to prevent deep-vein thrombosis in some at-risk patients. Deep-vein thrombosis is a potentially life-threatening disorder in which blood clots form in the deep veins in the body, particularly the legs.

"Presumably by giving heparin to prevent clotting in the veins, you decrease the likelihood that clots will travel to the lungs and cause a pulmonary embolism," he says. "One of the ways that people can die from a complication of stroke is by pulmonary embolism.

"These results emphasize the importance of reviewing all the evidence to develop practice guidelines," says Coull, professor and head of the department of neurology and professor of medicine, University of Arizona, Arizona Health Science Center in Tucson. "Despite decades of use and physiologic reasons for its use, there were surprisingly few randomized trials that addressed the effects of using heparin and other anticoagulants within a few hours of onset of symptoms."

The report should have a three-fold effect on clinical practice, says Coull. "We would hope that most acute ischemic stroke patients will receive antiplatelet therapy; that for every patient with acute stroke the issue of deep-vein thrombosis is addressed – whether heparin is used or not; and thirdly, that heparin be used sparingly in this setting unless there is a good rationale for using it."

More well-designed studies on the use of other antiplatelet drugs and anticoagulants are warranted, according to the writing group.

Co-authors were Linda Williams, M.D.; Larry Goldstein, M.D.; James Meschia, M.D.; Daragh Heitzman, M.D.; Seemant Chaturvedi, M.D.; Karen Johnston, M.D.; Sidney Starkman, M.D.; Lewis Morgenstern, M.D.; Janet Wilterdink, M.D.; Steve Levine, M.D. and Jeffrey Saver, M.D.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Cite This Page:

American Heart Association. "Aspirin Within Two Days Of Ischemic Stroke Reduces Deaths." ScienceDaily. ScienceDaily, 10 July 2002. <www.sciencedaily.com/releases/2002/07/020709055412.htm>.
American Heart Association. (2002, July 10). Aspirin Within Two Days Of Ischemic Stroke Reduces Deaths. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2002/07/020709055412.htm
American Heart Association. "Aspirin Within Two Days Of Ischemic Stroke Reduces Deaths." ScienceDaily. www.sciencedaily.com/releases/2002/07/020709055412.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins