Featured Research

from universities, journals, and other organizations

UCSD Researchers Identify Eye-Formation Strategy In Mice; Provides Clues To Development Of Other Organs

Date:
July 24, 2002
Source:
University Of California - San Diego
Summary:
Researchers at the University of California, San Diego (UCSD) School of Medicine have discovered a linkage between proteins that is an essential part of the complex series of molecular events leading to normal eye development in mice. The investigators also suggest that the combination of specific proteins in eye formation may be similar to yet unidentified genes that act together to allow development of other organs.

Researchers at the University of California, San Diego (UCSD) School of Medicine have discovered a linkage between proteins that is an essential part of the complex series of molecular events leading to normal eye development in mice. The investigators also suggest that the combination of specific proteins in eye formation may be similar to yet unidentified genes that act together to allow development of other organs.

Published in the July 19, 2002 issue of the journal Science, the research was done in the lab of Michael G. Rosenfeld, Ph.D., UCSD professor of medicine and an investigator with the Howard Hughes Medical Institute. The first author was Xue Li, Ph.D., a post-doctoral fellow in the Rosenfeld lab.

"A central issue in development of any mammalian organ is to get the right number of cells which make the size of each organ precise." Rosenfeld notes.

In studies with embryonic mice, the research team found that sine oculis/6 (Six6), one of a family of genes naturally expressed in eye development, actively enable normal eye size by stopping another set of genes that restrict eye cell-growth if left alone. Mice bred without the Six6 protein exhibited arrested eye development, sometimes with complete absence of optic nerve and optic chiasm, the location of x-crossed nerve fibers on the undersurface of the hypothalamus.

To determine if Six6 had a co-factor, or accomplice, in its developmental role, the researchers investigated it and other genes in cell cultures. They found that Six6 strongly interacted with another protein called dachshund/2 (Dach2). While Six6 alone exerted a weak repressive activity, it strongly assumed its normal role when associated with Dach2.

The research team also discovered that the linked Six6/Dach2 complex interacted with a gene called p27Kip1, a known inhibitor of cell proliferation. In cell cultures, they identified the region of the p27Kip1 gene where the Six6/Dach2 complex bound, then studied mouse retinas to prove that Six6/Dach2 regulated p27Kip1 acted together to control tissue growth.

The authors note in the paper that "together, these findings provide an organ-specific strategy for the expansion of precursor cell populations during development, a strategy likely to be used in other organ systems."

The Rosenfeld lab work was supported by grants from the National Institutes of Health, NRSA and Telethon/Italy.

In addition to Rosenfeld and Li, authors of the paper are Valentina Perissi, a UCSD graduate student, David W. Rose, Ph.D., UCSD associate professor of medicine, and Forrest Liu, M.D., UCSD Department of Medicine.


Story Source:

The above story is based on materials provided by University Of California - San Diego. Note: Materials may be edited for content and length.


Cite This Page:

University Of California - San Diego. "UCSD Researchers Identify Eye-Formation Strategy In Mice; Provides Clues To Development Of Other Organs." ScienceDaily. ScienceDaily, 24 July 2002. <www.sciencedaily.com/releases/2002/07/020724075843.htm>.
University Of California - San Diego. (2002, July 24). UCSD Researchers Identify Eye-Formation Strategy In Mice; Provides Clues To Development Of Other Organs. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2002/07/020724075843.htm
University Of California - San Diego. "UCSD Researchers Identify Eye-Formation Strategy In Mice; Provides Clues To Development Of Other Organs." ScienceDaily. www.sciencedaily.com/releases/2002/07/020724075843.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
More People Diagnosed With TB In 2013, But There's Good News

More People Diagnosed With TB In 2013, But There's Good News

Newsy (Oct. 22, 2014) The World Health Organizations says TB numbers rose in 2013, but it's partly due to better detection and more survivors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins