BOSTON – A study led by researchers at Dana-Farber Cancer Institute has shown that a drug extracted from porcine intestinal tissue reduced the risk of death in patients who experienced a severe and often-fatal complication of stem cell transplants. The experimental drug defibrotide reversed severe veno-occlusive disease (VOD) of the liver in more than one third of the stem cell transplant recipients enrolled in the study. VOD is a type of potentially fatal liver damage that can result from the high doses of chemotherapy given prior to a transplant. The findings, which will be published in the Dec. 15 issue of Blood, have been posted as a "First Edition Paper" on the journal's web site (www.bloodjournal.org).
The above story is based on materials provided by Dana-Farber Cancer Institute. Note: Materials may be edited for content and length.
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