Featured Research

from universities, journals, and other organizations

Neural Signal That Helps Wire Up Brain’s Movement Circuit Identified

Date:
September 11, 2002
Source:
Imperial College Of Science, Technology And Medicine
Summary:
Scientists from Imperial College London and King's College London have identified a molecule that helps to wire up the neural circuitry responsible for controlling the movement of muscle.

Scientists from Imperial College London and King's College London have identified a molecule that helps to wire up the neural circuitry responsible for controlling the movement of muscle.

Writing today in the journal Neuron, the researchers describe how the signalling protein named WNT-3 directs specific neurons during embryonic development to make the correct connections in the spine to form a neural pathway that controls muscle.

Using mice, which offer the closest model to human neurobiology, the scientists found that WNT-3 is only produced by motor neurons in the spinal cord at a crucial stage when sensory neurons come close to them.

"Assembling the components to connect any neural circuit is a complex process. During development of the brain and spinal cord a hundred million neurons are looking for their neural partners to make connections with," said Dr Patricia Salinas of Imperial's Department of Biological Sciences who led the study. "We found that motor neurons release the WNT-3 protein to guide sensory neurons to make connections with them."

The ability to collect and transmit information to the brain from the internal and external environment is dependent on the sensory system. Sensory neurons carry information about muscle tension and body position to motor neurons in the spinal cord to control muscle contraction.

The researchers took pieces of spinal tissue from embryonic mice and found that sensory neurons stop growing and begin to branch ready to form a functional connection or synapse when the WNT-3 signal is sent out.

Tissue culture studies confirmed that the presence of WNT-3 causes sensory neurons to remodel themselves in readiness for neurotransmission.

"The molecular identities of signals that regulate formation of specific connections between sensory and motor neurons were previously unknown. Understanding the complex web of instructions that direct this intricate process may have important implications for neural regeneration following spinal injury," said Dr Salinas.


Story Source:

The above story is based on materials provided by Imperial College Of Science, Technology And Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Imperial College Of Science, Technology And Medicine. "Neural Signal That Helps Wire Up Brain’s Movement Circuit Identified." ScienceDaily. ScienceDaily, 11 September 2002. <www.sciencedaily.com/releases/2002/09/020911072244.htm>.
Imperial College Of Science, Technology And Medicine. (2002, September 11). Neural Signal That Helps Wire Up Brain’s Movement Circuit Identified. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2002/09/020911072244.htm
Imperial College Of Science, Technology And Medicine. "Neural Signal That Helps Wire Up Brain’s Movement Circuit Identified." ScienceDaily. www.sciencedaily.com/releases/2002/09/020911072244.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins