Featured Research

from universities, journals, and other organizations

Neural Signal That Helps Wire Up Brain’s Movement Circuit Identified

Date:
September 11, 2002
Source:
Imperial College Of Science, Technology And Medicine
Summary:
Scientists from Imperial College London and King's College London have identified a molecule that helps to wire up the neural circuitry responsible for controlling the movement of muscle.

Scientists from Imperial College London and King's College London have identified a molecule that helps to wire up the neural circuitry responsible for controlling the movement of muscle.

Related Articles


Writing today in the journal Neuron, the researchers describe how the signalling protein named WNT-3 directs specific neurons during embryonic development to make the correct connections in the spine to form a neural pathway that controls muscle.

Using mice, which offer the closest model to human neurobiology, the scientists found that WNT-3 is only produced by motor neurons in the spinal cord at a crucial stage when sensory neurons come close to them.

"Assembling the components to connect any neural circuit is a complex process. During development of the brain and spinal cord a hundred million neurons are looking for their neural partners to make connections with," said Dr Patricia Salinas of Imperial's Department of Biological Sciences who led the study. "We found that motor neurons release the WNT-3 protein to guide sensory neurons to make connections with them."

The ability to collect and transmit information to the brain from the internal and external environment is dependent on the sensory system. Sensory neurons carry information about muscle tension and body position to motor neurons in the spinal cord to control muscle contraction.

The researchers took pieces of spinal tissue from embryonic mice and found that sensory neurons stop growing and begin to branch ready to form a functional connection or synapse when the WNT-3 signal is sent out.

Tissue culture studies confirmed that the presence of WNT-3 causes sensory neurons to remodel themselves in readiness for neurotransmission.

"The molecular identities of signals that regulate formation of specific connections between sensory and motor neurons were previously unknown. Understanding the complex web of instructions that direct this intricate process may have important implications for neural regeneration following spinal injury," said Dr Salinas.


Story Source:

The above story is based on materials provided by Imperial College Of Science, Technology And Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Imperial College Of Science, Technology And Medicine. "Neural Signal That Helps Wire Up Brain’s Movement Circuit Identified." ScienceDaily. ScienceDaily, 11 September 2002. <www.sciencedaily.com/releases/2002/09/020911072244.htm>.
Imperial College Of Science, Technology And Medicine. (2002, September 11). Neural Signal That Helps Wire Up Brain’s Movement Circuit Identified. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2002/09/020911072244.htm
Imperial College Of Science, Technology And Medicine. "Neural Signal That Helps Wire Up Brain’s Movement Circuit Identified." ScienceDaily. www.sciencedaily.com/releases/2002/09/020911072244.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins