Featured Research

from universities, journals, and other organizations

New Breast Cancer Gene Discovered

Date:
October 9, 2002
Source:
Cold Spring Harbor Laboratory
Summary:
Scientists at Cold Spring Harbor Laboratory and the University of Washington have discovered a new tumor suppressor gene that is missing or inactive in as many as 60% of breast cancers, and is also altered in lung cancer.

Scientists at Cold Spring Harbor Laboratory and the University of Washington have discovered a new tumor suppressor gene that is missing or inactive in as many as 60% of breast cancers, and is also altered in lung cancer.

Related Articles


The discovery of the gene, called DBC2 (for deleted in breast cancer) is highly significant because DBC2 is among the first tumor suppressor genes to be clearly associated with sporadic breast cancer. Sporadic disease accounts for greater than 90% of all forms of breast and other cancers, in contrast to heritable forms of cancer, which account for a relatively small percentage of the disease.

Importantly, the researchers showed that production of the Dbc2 protein in breast cancer cells kills the cancer cells or stops them from growing.

The study--to be published on October 15 in the Proceedings of the National Academy of Sciences--will be published on-line (at PNAS Early Edition, http://www.pnas.org/papbyrecent.shtml) during the week of October 7. The media emargo will lift at 5:00 PM EST on Monday, October 7.

In 1997, the same research group at Cold Spring Harbor Laboratory, led by Dr. Michael Wigler, identified one of the only other tumor suppressor genes (called PTEN) to be clearly associated with sporadic cancer. In 1981, Dr. Wigler's group discovered the first cancer-causing oncogene, called RAS, from human cells.

In 1990, the same research group at the University of Washington, led by Dr. Mary-Claire King, discovered the first gene linked to hereditary breast cancer, called BRCA1.


Story Source:

The above story is based on materials provided by Cold Spring Harbor Laboratory. Note: Materials may be edited for content and length.


Cite This Page:

Cold Spring Harbor Laboratory. "New Breast Cancer Gene Discovered." ScienceDaily. ScienceDaily, 9 October 2002. <www.sciencedaily.com/releases/2002/10/021009081201.htm>.
Cold Spring Harbor Laboratory. (2002, October 9). New Breast Cancer Gene Discovered. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2002/10/021009081201.htm
Cold Spring Harbor Laboratory. "New Breast Cancer Gene Discovered." ScienceDaily. www.sciencedaily.com/releases/2002/10/021009081201.htm (accessed October 31, 2014).

Share This



More Health & Medicine News

Friday, October 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Melafind: Spotting Melanoma Without a Biopsy

Melafind: Spotting Melanoma Without a Biopsy

Ivanhoe (Oct. 31, 2014) The MelaFind device is a pain-free way to check suspicious moles for melanoma, without the need for a biopsy. Video provided by Ivanhoe
Powered by NewsLook.com
Battling Multiple Myeloma

Battling Multiple Myeloma

Ivanhoe (Oct. 31, 2014) The answer isn’t always found in new drugs – repurposing an ‘old’ drug that could mean better multiple myeloma treatment, and hope. Video provided by Ivanhoe
Powered by NewsLook.com
Chronic Inflammation and Prostate Cancer

Chronic Inflammation and Prostate Cancer

Ivanhoe (Oct. 31, 2014) New information that is linking chronic inflammation in the prostate and prostate cancer, which may help doctors and patients prevent cancer in the future. Video provided by Ivanhoe
Powered by NewsLook.com
Sickle Cell: Stopping Kids’ Silent Strokes

Sickle Cell: Stopping Kids’ Silent Strokes

Ivanhoe (Oct. 31, 2014) Blood transfusions are proving crucial to young sickle cell patients by helping prevent strokes, even when there is no outward sign of brain injury. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins