Featured Research

from universities, journals, and other organizations

UIC Research Suggests New Way To Stop Growth Of Cancer Cells

Date:
November 14, 2002
Source:
University Of Illinois At Chicago
Summary:
A new study from the UIC College of Pharmacy may lead to the development of a drug to stop the growth of cancer cells. The study, published in the September issue of the journal Nature Medicine, was described in an editorial in the journal Nature as being among the most important recent findings in cancer-targeting research.

A new study from the UIC College of Pharmacy may lead to the development of a drug to stop the growth of cancer cells. The study, published in the September issue of the journal Nature Medicine, was described in an editorial in the journal Nature as being among the most important recent findings in cancer-targeting research.

Dr. Lucio Miele, associate professor of biopharmaceutical sciences, and his team have developed a gene therapy approach as well as a potentially new use for a class of drugs known as GSIs, or gamma-secretase inhibitors, which are already under investigation as a treatment for Alzheimer's disease.

GSIs are drugs that block gamma secretase, an enzyme that produces a harmful protein in the brains of people with Alzheimer's. Miele's study shows that inhibiting gamma secretase also can block intercellular communications in cancer cells.

Cancer occurs when several genes within a cell are damaged. Earlier research has found that a type of gene called Ras is one of the most commonly damaged or inappropriately activated genes in human malignant tumors. Miele's research builds on that discovery.

His findings show that when damaged or excessively activated in human cells, Ras, through gamma secretase, activates a protein known as Notch-1, which in turn triggers a chain of events that allow cancer cells to grow.

"If we stop Notch, we stop Ras and, ultimately, we can stop cancers that depend on it for survival," Miele says.

Miele is one of several scientists who have been finding Notch gene alterations in various cancers. "But all that had been found so far was that the expression of these genes seemed increased in various tumors for unknown reasons," Miele said. "Nobody had described what causes this alteration, nor, most importantly, that these genes and proteins can be directly targeted for cancer treatment.

"The really exciting discovery for us is that you can stop cancer cells by just switching off these Notch genes or blocking the activation of notch proteins by gamma secretase," he said.

"This therapy works very well in model human cancer cells created in the laboratory, and it works even better in cells from an actual cervical cancer," Miele said, noting that this result was demonstrated both in the test tube and in experimental tumors formed by human cancer cells in mice. The test tube and mouse studies indicate that gamma secretase inhibitors warrant further investigation, he says. "This means there is a new potential target against which cancer drugs can be developed."

While Miele cautions that more studies are needed to establish which types of cancer could benefit from gamma secretase-blocking drugs or Notch-blocking gene therapy, he says his research and work from other laboratories indicate the potential for therapeutic applications to several types of human malignancies, including breast, cervical, head and neck, endometrial and renal cancers, some colon and lung cancers, aggressive melanomas, pleural mesotheliomas and certain lymphomas and leukemias.

Miele, a member of the UIC Cancer Center, expects to begin preliminary testing next year that may eventually lead to human clinical trials.

For more information about the UIC Cancer Center, visit www.uic.edu/com/cancer/


Story Source:

The above story is based on materials provided by University Of Illinois At Chicago. Note: Materials may be edited for content and length.


Cite This Page:

University Of Illinois At Chicago. "UIC Research Suggests New Way To Stop Growth Of Cancer Cells." ScienceDaily. ScienceDaily, 14 November 2002. <www.sciencedaily.com/releases/2002/11/021114072733.htm>.
University Of Illinois At Chicago. (2002, November 14). UIC Research Suggests New Way To Stop Growth Of Cancer Cells. ScienceDaily. Retrieved August 31, 2014 from www.sciencedaily.com/releases/2002/11/021114072733.htm
University Of Illinois At Chicago. "UIC Research Suggests New Way To Stop Growth Of Cancer Cells." ScienceDaily. www.sciencedaily.com/releases/2002/11/021114072733.htm (accessed August 31, 2014).

Share This




More Health & Medicine News

Sunday, August 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

Reuters - US Online Video (Aug. 30, 2014) California lawmakers pass a bill requiring universities to adopt "affirmative consent" language in their definitions of consensual sex, part of a nationwide drive to curb sexual assault on campuses. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins