Featured Research

from universities, journals, and other organizations

University Of Pittsburgh Study Finds Carbon Monoxide Has Therapeutic Benefits

Date:
January 20, 2003
Source:
University Of Pittsburgh Medical Center
Summary:
Exposing rats to low levels of carbon monoxide (CO) prior to aorta transplantation prevents arteriosclerosis associated with chronic organ rejection and can also suppress stenosis after balloon-angioplasty-induced carotid artery injury, according to a study published in the Feb. 1 edition of Nature Medicine. The article is published online today.

PITTSBURGH, Jan. 19 – Exposing rats to low levels of carbon monoxide (CO) prior to aorta transplantation prevents arteriosclerosis associated with chronic organ rejection and can also suppress stenosis after balloon-angioplasty-induced carotid artery injury, according to a study published in the Feb. 1 edition of Nature Medicine. The article is published online today.

"These findings demonstrate a significant protective role for CO in vascular injury and support its use as a therapeutic agent," according to study author Leo Otterbein, Ph.D., research assistant professor, University of Pittsburgh School of Medicine, division of pulmonary and critical care medicine.

The rats that received the aorta grafts were exposed to 250 parts per million (PPM) of CO immediately following transplantation and for the subsequent 56 days of the study. Those rats in the balloon injury portion of the study were exposed to the same PPM of CO for one hour prior to injury and then returned to room air for the subsequent 2 weeks.

As controls, researchers transplanted aortic segments from ten Norway rats to Lewis rats, none of which were exposed to CO. Arteriosclerotic lesions began to appear after 20-30 days and were significant by 50-60 days. Lesions were characterized by intimal hyperplasia (vessel wall thickening), an increase in smooth muscle cells and leukocyte accumulation in the transplanted aorta. These processes are indications of arteriosclerosis and limit the success of transplants and angioplasties in humans. In the rats exposed to CO, intimal hyperplasia was significantly reduced by 61 percent.

In the second group of rats, their carotid arteries developed intimal hyperplasia 14 days after balloon injury. Intimal hyperplasia in rats exposed to CO for only one hour prior to injury, was reduced by 74 percent over control rats exposed to air.

"Currently the best available treatment of clogged arteries is through angioplasty and a stent or via bypass surgery," said Brian S. Zuckerbraun, M.D., general surgery resident at the University of Pittsburgh School of Medicine and co-author of the study. "But these have their limitations and a significant failure rate. If you could pre-treat patients with CO it might result in a better long term outcome."

"Our research suggests that the protective effect of CO relies on its ability to block leukocyte infiltration/activation as well as small muscle cell proliferation," Dr. Otterbein said. "CO may prove to be beneficial in the treatment of a broad range of vascular diseases. The fact that a one-hour pre-exposure of a rat to low levels of CO markedly diminished the intimal proliferation that usually follows balloon injury, used here as a model of angioplasty, supports the use of CO clinically."

In the study, there were no observed negative effects of the CO exposure on the animals. According to Dr. Otterbein, studies are currently underway in a pig model.

Others involved in the research project at the University of Pittsburgh include Augustine Choi, M.D., chief of pulmonary, allergy and critical care medicine; Timothy Billiar, M.D., chairman of the department of surgery; Edith Tzeng, M.D., assistant professor of surgery in the division of vascular surgery; Ruiping Song, M.D., Ph.D., post doctoral fellow; and Fang Liu, technician. This study was done in collaboration with a team of researchers at Harvard Medical School.

The study was supported by grants from the National Institutes of Health, an Atorvastin Research Award, sponsored by Pfizer, American Heart Association, and the Ethicon-Society of University Surgeons Resident Research Award.


Story Source:

The above story is based on materials provided by University Of Pittsburgh Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University Of Pittsburgh Medical Center. "University Of Pittsburgh Study Finds Carbon Monoxide Has Therapeutic Benefits." ScienceDaily. ScienceDaily, 20 January 2003. <www.sciencedaily.com/releases/2003/01/030120100400.htm>.
University Of Pittsburgh Medical Center. (2003, January 20). University Of Pittsburgh Study Finds Carbon Monoxide Has Therapeutic Benefits. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2003/01/030120100400.htm
University Of Pittsburgh Medical Center. "University Of Pittsburgh Study Finds Carbon Monoxide Has Therapeutic Benefits." ScienceDaily. www.sciencedaily.com/releases/2003/01/030120100400.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins