Featured Research

from universities, journals, and other organizations

University Of Pittsburgh Study Finds Carbon Monoxide Has Therapeutic Benefits

Date:
January 20, 2003
Source:
University Of Pittsburgh Medical Center
Summary:
Exposing rats to low levels of carbon monoxide (CO) prior to aorta transplantation prevents arteriosclerosis associated with chronic organ rejection and can also suppress stenosis after balloon-angioplasty-induced carotid artery injury, according to a study published in the Feb. 1 edition of Nature Medicine. The article is published online today.

PITTSBURGH, Jan. 19 – Exposing rats to low levels of carbon monoxide (CO) prior to aorta transplantation prevents arteriosclerosis associated with chronic organ rejection and can also suppress stenosis after balloon-angioplasty-induced carotid artery injury, according to a study published in the Feb. 1 edition of Nature Medicine. The article is published online today.

"These findings demonstrate a significant protective role for CO in vascular injury and support its use as a therapeutic agent," according to study author Leo Otterbein, Ph.D., research assistant professor, University of Pittsburgh School of Medicine, division of pulmonary and critical care medicine.

The rats that received the aorta grafts were exposed to 250 parts per million (PPM) of CO immediately following transplantation and for the subsequent 56 days of the study. Those rats in the balloon injury portion of the study were exposed to the same PPM of CO for one hour prior to injury and then returned to room air for the subsequent 2 weeks.

As controls, researchers transplanted aortic segments from ten Norway rats to Lewis rats, none of which were exposed to CO. Arteriosclerotic lesions began to appear after 20-30 days and were significant by 50-60 days. Lesions were characterized by intimal hyperplasia (vessel wall thickening), an increase in smooth muscle cells and leukocyte accumulation in the transplanted aorta. These processes are indications of arteriosclerosis and limit the success of transplants and angioplasties in humans. In the rats exposed to CO, intimal hyperplasia was significantly reduced by 61 percent.

In the second group of rats, their carotid arteries developed intimal hyperplasia 14 days after balloon injury. Intimal hyperplasia in rats exposed to CO for only one hour prior to injury, was reduced by 74 percent over control rats exposed to air.

"Currently the best available treatment of clogged arteries is through angioplasty and a stent or via bypass surgery," said Brian S. Zuckerbraun, M.D., general surgery resident at the University of Pittsburgh School of Medicine and co-author of the study. "But these have their limitations and a significant failure rate. If you could pre-treat patients with CO it might result in a better long term outcome."

"Our research suggests that the protective effect of CO relies on its ability to block leukocyte infiltration/activation as well as small muscle cell proliferation," Dr. Otterbein said. "CO may prove to be beneficial in the treatment of a broad range of vascular diseases. The fact that a one-hour pre-exposure of a rat to low levels of CO markedly diminished the intimal proliferation that usually follows balloon injury, used here as a model of angioplasty, supports the use of CO clinically."

In the study, there were no observed negative effects of the CO exposure on the animals. According to Dr. Otterbein, studies are currently underway in a pig model.

Others involved in the research project at the University of Pittsburgh include Augustine Choi, M.D., chief of pulmonary, allergy and critical care medicine; Timothy Billiar, M.D., chairman of the department of surgery; Edith Tzeng, M.D., assistant professor of surgery in the division of vascular surgery; Ruiping Song, M.D., Ph.D., post doctoral fellow; and Fang Liu, technician. This study was done in collaboration with a team of researchers at Harvard Medical School.

The study was supported by grants from the National Institutes of Health, an Atorvastin Research Award, sponsored by Pfizer, American Heart Association, and the Ethicon-Society of University Surgeons Resident Research Award.


Story Source:

The above story is based on materials provided by University Of Pittsburgh Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University Of Pittsburgh Medical Center. "University Of Pittsburgh Study Finds Carbon Monoxide Has Therapeutic Benefits." ScienceDaily. ScienceDaily, 20 January 2003. <www.sciencedaily.com/releases/2003/01/030120100400.htm>.
University Of Pittsburgh Medical Center. (2003, January 20). University Of Pittsburgh Study Finds Carbon Monoxide Has Therapeutic Benefits. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2003/01/030120100400.htm
University Of Pittsburgh Medical Center. "University Of Pittsburgh Study Finds Carbon Monoxide Has Therapeutic Benefits." ScienceDaily. www.sciencedaily.com/releases/2003/01/030120100400.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins