Featured Research

from universities, journals, and other organizations

Anti-HIV Protein From Blue-green Algae Also Inhibits Ebola Infection

Date:
March 5, 2003
Source:
NIH/National Cancer Institute
Summary:
Researchers have discovered that a bacterial protein known to reduce the ability of the human immunodeficiency virus (HIV) to infect cells also inhibits infection by the Ebola virus. The antiviral protein, known as cyanovirin-N (CV-N), can extend the survival time of Ebola-infected mice, researchers from the National Cancer Institute's Molecular Targets Discovery Program report in a study published in Antiviral Research.

Researchers have discovered that a bacterial protein known to reduce the ability of the human immunodeficiency virus (HIV) to infect cells also inhibits infection by the Ebola virus. The antiviral protein, known as cyanovirin-N (CV-N), can extend the survival time of Ebola-infected mice, researchers from the National Cancer Institute's Molecular Targets Discovery Program report in a study published in Antiviral Research.

Related Articles


The study, done in collaboration with researchers from the U.S. Army Medical Research Institute of Infectious Diseases, the Centers for Disease Control and Prevention, and the National Institute of Diabetes and Digestive and Kidney Diseases, provides important insights into the process of Ebola infection. There is currently no treatment for Ebola infection, which causes severe and often fatal hemorrhagic fever.

CV-N comes from a type of bacterium known as cyanobacterium, or blue-green algae. Its antiviral properties were originally discovered through NCI's Laboratory of Drug Discovery Research and Development in a screening process designed to identify natural materials that act against HIV. CV-N effectively inhibits HIV infection of cells grown in the laboratory.

"CV-N is extremely effective against a broad range of HIV strains," said Barry O'Keefe, Ph.D., of NCI's Center for Cancer Research, one of the authors of the study. It is currently being investigated in the laboratory as a potential topical microbicide to prevent the sexual transmission of HIV.

CV-N inhibits HIV infection by binding to the outside of the virus and physically blocking it from entering cells. The protein is known to attach to a particular sugar molecule on the virus surface, and because similar sugar molecules coat the Ebola virus, researchers hoped CV-N might have the same effect on Ebola that it does on HIV.

Their hypothesis proved to be true when laboratory experiments revealed that CV-N does bind to the sugar molecules on the outside of the Ebola virus and inhibit its ability to infect cells, much as it does with HIV. Furthermore, when researchers injected CV-N into mice prior to infecting the animals with Ebola, then continued to inject CV-N once a day, the onset of visible illness was delayed and the animals survived longer than those not treated with CV-N.

"CV-N is the first molecule known to inhibit Ebola infection by interfering with the virus's ability to enter cells," said O'Keefe. Although researchers believe it is unlikely that CV-N itself will be an effective treatment for Ebola infection, understanding the specific molecules involved in CV-N's interaction with the virus will help clarify the processes necessary for infection. Scientists are optimistic that this knowledge eventually may lead to useful therapies.

###

For more information about cancer, visit NCI's Web site at http://www.cancer.gov .


Story Source:

The above story is based on materials provided by NIH/National Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

NIH/National Cancer Institute. "Anti-HIV Protein From Blue-green Algae Also Inhibits Ebola Infection." ScienceDaily. ScienceDaily, 5 March 2003. <www.sciencedaily.com/releases/2003/03/030305081547.htm>.
NIH/National Cancer Institute. (2003, March 5). Anti-HIV Protein From Blue-green Algae Also Inhibits Ebola Infection. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2003/03/030305081547.htm
NIH/National Cancer Institute. "Anti-HIV Protein From Blue-green Algae Also Inhibits Ebola Infection." ScienceDaily. www.sciencedaily.com/releases/2003/03/030305081547.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) — The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins