Featured Research

from universities, journals, and other organizations

Anti-HIV Protein From Blue-green Algae Also Inhibits Ebola Infection

Date:
March 5, 2003
Source:
NIH/National Cancer Institute
Summary:
Researchers have discovered that a bacterial protein known to reduce the ability of the human immunodeficiency virus (HIV) to infect cells also inhibits infection by the Ebola virus. The antiviral protein, known as cyanovirin-N (CV-N), can extend the survival time of Ebola-infected mice, researchers from the National Cancer Institute's Molecular Targets Discovery Program report in a study published in Antiviral Research.

Researchers have discovered that a bacterial protein known to reduce the ability of the human immunodeficiency virus (HIV) to infect cells also inhibits infection by the Ebola virus. The antiviral protein, known as cyanovirin-N (CV-N), can extend the survival time of Ebola-infected mice, researchers from the National Cancer Institute's Molecular Targets Discovery Program report in a study published in Antiviral Research.

The study, done in collaboration with researchers from the U.S. Army Medical Research Institute of Infectious Diseases, the Centers for Disease Control and Prevention, and the National Institute of Diabetes and Digestive and Kidney Diseases, provides important insights into the process of Ebola infection. There is currently no treatment for Ebola infection, which causes severe and often fatal hemorrhagic fever.

CV-N comes from a type of bacterium known as cyanobacterium, or blue-green algae. Its antiviral properties were originally discovered through NCI's Laboratory of Drug Discovery Research and Development in a screening process designed to identify natural materials that act against HIV. CV-N effectively inhibits HIV infection of cells grown in the laboratory.

"CV-N is extremely effective against a broad range of HIV strains," said Barry O'Keefe, Ph.D., of NCI's Center for Cancer Research, one of the authors of the study. It is currently being investigated in the laboratory as a potential topical microbicide to prevent the sexual transmission of HIV.

CV-N inhibits HIV infection by binding to the outside of the virus and physically blocking it from entering cells. The protein is known to attach to a particular sugar molecule on the virus surface, and because similar sugar molecules coat the Ebola virus, researchers hoped CV-N might have the same effect on Ebola that it does on HIV.

Their hypothesis proved to be true when laboratory experiments revealed that CV-N does bind to the sugar molecules on the outside of the Ebola virus and inhibit its ability to infect cells, much as it does with HIV. Furthermore, when researchers injected CV-N into mice prior to infecting the animals with Ebola, then continued to inject CV-N once a day, the onset of visible illness was delayed and the animals survived longer than those not treated with CV-N.

"CV-N is the first molecule known to inhibit Ebola infection by interfering with the virus's ability to enter cells," said O'Keefe. Although researchers believe it is unlikely that CV-N itself will be an effective treatment for Ebola infection, understanding the specific molecules involved in CV-N's interaction with the virus will help clarify the processes necessary for infection. Scientists are optimistic that this knowledge eventually may lead to useful therapies.

###

For more information about cancer, visit NCI's Web site at http://www.cancer.gov .


Story Source:

The above story is based on materials provided by NIH/National Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

NIH/National Cancer Institute. "Anti-HIV Protein From Blue-green Algae Also Inhibits Ebola Infection." ScienceDaily. ScienceDaily, 5 March 2003. <www.sciencedaily.com/releases/2003/03/030305081547.htm>.
NIH/National Cancer Institute. (2003, March 5). Anti-HIV Protein From Blue-green Algae Also Inhibits Ebola Infection. ScienceDaily. Retrieved August 2, 2014 from www.sciencedaily.com/releases/2003/03/030305081547.htm
NIH/National Cancer Institute. "Anti-HIV Protein From Blue-green Algae Also Inhibits Ebola Infection." ScienceDaily. www.sciencedaily.com/releases/2003/03/030305081547.htm (accessed August 2, 2014).

Share This




More Health & Medicine News

Saturday, August 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Quintuplets Head Home

Texas Quintuplets Head Home

Reuters - US Online Video (Aug. 1, 2014) After four months in the hospital, the first quintuplets to be born at Baylor University Medical Center head home. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Patient Coming to U.S. for Treatment

Ebola Patient Coming to U.S. for Treatment

Reuters - US Online Video (Aug. 1, 2014) A U.S. aid worker infected with Ebola while working in West Africa will be treated in a high security ward at Emory University in Atlanta. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Vaccine Might Be Coming, But Where's It Been?

Ebola Vaccine Might Be Coming, But Where's It Been?

Newsy (Aug. 1, 2014) Health officials are working to fast-track a vaccine — the West-African Ebola outbreak has killed more than 700. But why didn't we already have one? Video provided by Newsy
Powered by NewsLook.com
Study Links Certain Birth Control Pills To Breast Cancer

Study Links Certain Birth Control Pills To Breast Cancer

Newsy (Aug. 1, 2014) Previous studies have made the link between birth control and breast cancer, but the latest makes the link to high-estrogen oral contraceptives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins