Featured Research

from universities, journals, and other organizations

Clue To Prion Formation Found, Offers Step Toward Treating Puzzling Diseases

Date:
May 9, 2003
Source:
Dartmouth Medical School
Summary:
Dartmouth Medical School biochemists studying the mysteries of prion particles have discovered a novel step in their formation. Their results, reported in a recent issue of Biochemistry could help provide a new approach for therapy against prion diseases.

HANOVER, NH -- Prions—their existence is intriguing and their links to disease are unsettling. These unconventional infectious agents are involved in mad cow disease and other fatal brain illnesses in humans and animals, rattling prior assumptions about the spread of infections.

Related Articles


Dartmouth Medical School biochemists studying the mysteries of these prion particles have discovered a novel step in their formation. Their results, reported in a recent issue of Biochemistry could help provide a new approach for therapy against prion diseases. The team, headed by Dr. Surachai Supattapone, assistant professor of biochemistry and of medicine, includes Ralf Lucassen and Koren Nishina.

The cause of certain neurodegenerative diseases has long stymied scientists. The variant Creutzfeldt-Jakob disease in humans -- which is linked to bovine spongiform encephalopathy or mad cow disease -- as well as scrapie in sheep and chronic wasting disease in deer and elk are transmissible.

Yet the infectious agent is not a parasite, fungus, bacterium or virus. Instead, it seems to be a prion, which is a protein, but an abnormally shaped one. A normal brain protein called PrPC misfolds into the prion protein called PrPSc. Until prions were discovered, proteins were not considered agents of infection.

Still unknown is how PrPC turns into PrPSc, which is characterized biochemically by being resistant to enyzme digestion. The researchers created a system to study the conversion into PrPSc in a test tube.

“We found that we could inhibit this conversion with compounds that block free sulfhydryl groups,” said Supattapone. “This is the first discovery that formation of PrPSc requires a reactive chemical group. It is a clue that there may be a cofactor containing the free sulfhydryl group, such as an enzyme that helps to catalyze the process of forming PrPSc from PrPC. Moreover, it may be a first step of a logical approach to find a therapeutic strategy against prion disease based on specifically inhibiting a catalytic cofactor.”


Story Source:

The above story is based on materials provided by Dartmouth Medical School. Note: Materials may be edited for content and length.


Cite This Page:

Dartmouth Medical School. "Clue To Prion Formation Found, Offers Step Toward Treating Puzzling Diseases." ScienceDaily. ScienceDaily, 9 May 2003. <www.sciencedaily.com/releases/2003/05/030509084657.htm>.
Dartmouth Medical School. (2003, May 9). Clue To Prion Formation Found, Offers Step Toward Treating Puzzling Diseases. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2003/05/030509084657.htm
Dartmouth Medical School. "Clue To Prion Formation Found, Offers Step Toward Treating Puzzling Diseases." ScienceDaily. www.sciencedaily.com/releases/2003/05/030509084657.htm (accessed October 23, 2014).

Share This



More Mind & Brain News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Academic Scandal Shocks UNC

Academic Scandal Shocks UNC

AP (Oct. 23, 2014) A scandal involving bogus classes and inflated grades at the University of North Carolina was bigger than previously reported, a new investigation found. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Working Mother Getaway: Beaches Turks & Caicos

Working Mother Getaway: Beaches Turks & Caicos

Working Mother (Oct. 22, 2014) Feast your eyes on this gorgeous family-friendly resort. Video provided by Working Mother
Powered by NewsLook.com
What Your Favorite Color Says About You

What Your Favorite Color Says About You

Buzz60 (Oct. 22, 2014) We all have one color we love to wear, and believe it or not, your color preference may reveal some of your character traits. In celebration of National Color Day, Krystin Goodwin (@kyrstingoodwin) highlights what your favorite colors may say about you. Video provided by Buzz60
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins