Featured Research

from universities, journals, and other organizations

Designer Molecules – Engineering A Better Approach To HIV Treatment

Date:
May 20, 2003
Source:
Rensselaer Polytechnic Institute
Summary:
Ravi Kane, assistant professor of chemical engineering at Rensselaer Polytechnic Institute, is designing brand-new molecules that may one day fend off an HIV infection. Bolstering the body’s molecular defenses is a novel method that may lead to highly effective treatments for HIV, the virus that can lead to AIDS.

TROY, N.Y. – Ravi Kane, assistant professor of chemical engineering at Rensselaer Polytechnic Institute, is designing brand-new molecules that may one day fend off an HIV infection. Bolstering the body’s molecular defenses is a novel method that may lead to highly effective treatments for HIV, the virus that can lead to AIDS.

Related Articles


Kane has received a two-year, $150,000 grant from the National Institute of Allergy and Infectious Disease (NIAID), a division of the National Institutes of Health, to pursue research into this promising HIV treatment.

The Trouble With Today’s Treatments

Today’s FDA-approved HIV treatments take aim at the virus itself. Drugs used in the standard “cocktail” regimens, including reverse transcriptase and protease inhibitors, are intended to disable HIV at two stages in its replication process. Such treatments are undoubtedly lifesaving for many people; however, they deliver varying success due to the ongoing emergence of resistant HIV strains. These drugs are also expensive and lead to a host of side-effects, including lipodystrophy (abnormal fat accumulation or loss in certain parts of the body) and dangerously high cholesterol and triglyceride levels.

A New Approach: Defensive Maneuvers

Kane’s research team at Rensselaer, and Albany Medical Center collaborators Kathy Stellrecht and Dennis Metzger, are trying a different approach. The Rensselaer team is designing molecules that block the particular receptors (located on human cells) that act as the docking sites where the majority of HIV strains make their first attempt at infiltration. These receptors are present all over the cell surface, requiring a molecule with a “multi-armed” (or multivalent) structure to do the best job of preventing a virus from docking.

“Multivalency allows us to block more than one receptor with each molecule,” says Kane. “This approach has the potential to be very effective – in fact, orders of magnitude more effective than any existing treatment.”

There are multiple benefits to treating HIV by blocking its entrance to human cells. In contrast to the constantly mutating virus cells, the human receptors are stable and do not change over time, making development of resistance to a blocking drug unlikely. In addition, the new entry inhibitors may be extremely effective without any dangerous side-effects. People with a genetic defect (a natural blockage) in this receptor show immunity to HIV infection, but are otherwise normal. The researchers admit that this preliminary research is very exciting; however, further study and testing will be needed to develop a viable treatment.

“We hope the next two years of work will form the basis of a more detailed grant in the future,” says Kane.


Story Source:

The above story is based on materials provided by Rensselaer Polytechnic Institute. Note: Materials may be edited for content and length.


Cite This Page:

Rensselaer Polytechnic Institute. "Designer Molecules – Engineering A Better Approach To HIV Treatment." ScienceDaily. ScienceDaily, 20 May 2003. <www.sciencedaily.com/releases/2003/05/030520082652.htm>.
Rensselaer Polytechnic Institute. (2003, May 20). Designer Molecules – Engineering A Better Approach To HIV Treatment. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2003/05/030520082652.htm
Rensselaer Polytechnic Institute. "Designer Molecules – Engineering A Better Approach To HIV Treatment." ScienceDaily. www.sciencedaily.com/releases/2003/05/030520082652.htm (accessed March 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins